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Research group A01: Elucidation of ubiquitin functions by chemo-technologies

Analysis of ubiquitin-related molecules for protein sorting to exosomes by UBL3 chemo-technology

Hiroshi Ageta, PhD

Fujita Health University, Institute for Comprehensive Medical Science (ICMS), Senior Assistant Professor

Development of therapeutic strategies for various diseases by regulation of the cell death/survival balance using ubiquitin chemo-technologies

Atsushi Matsuzawa, PhD

Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University Professor

The mechanism of action of the deubiquitinating enzyme USP8 revealed by chemo-technologies

Toshiaki Fukushima, PhD

Tokyo Institute of Technology, Institute of Innovative Research, Cell Biology Center, Komada Laboratory Assistant Professor

Elucidation of the mechanism of plasma membrane protein quality control by RFFL and its application to CF drug discovery

Tsukasa Okiyoneda, PhD

Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University Professor

Physicochemical properties and molecular regulation of TRIM-type ubiquitin ligases

Shigetsugu Hatakeyama, MD, PhD

Department of Biochemistry, Faculty of Medicine, Hokkaido University Professor

Elucidation of the preemptive quality control-specific ubiquitin receptors using chemo-technologies.

Hiroyuki Kawahara, PhD

Tokyo Metropolitan University, Department of Biological Sciences Professor

Pathobiochemical analysis using chemo-technologies targeting linear ubiquitin chain

Daisuke Oikawa, PhD

Department of Pathobiochemistry, Graduate School of Medicine, Osaka City University. Associate Professor

Molecular basis of RQC control via targeting of specific ubiquitin chains　

Toshifumi Inada, PhD

Institute of Medical Science, The University of Tokyo Principal Investigator, Professor

Function and dysfunction of atypical ubiquitylation, and its artificial control

Daisuke Morito, PhD

Showa University School of Medicine, Department of Biochemistry Associate Professor

Mechanistic studies of ubiquitin signaling at DNA methylation sites using chemo-technology

Atsuya Nishiyama, PhD

Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo Associate Professor

Research group A02: Development of ubiquitin chemo-technologies

Development of non-hydrolysable alkene-type ubiquitin bond isosteres for ubiquitin research

Tetsuo Narumi, PhD

Shizuoka University, Graduate School of Integrated Science and Technology, Laboratory of Bioorganic Chemistry Principal Investigator, Associate Professor

Efficient Chemical Synthesis of Polyubiquitin and Ubiquitinated Proteins

Gosuke Hayashi, PhD

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University Associate Professor

Screening for small molecule competitors of the phosphorylated substrates ofβ-TrCP and their application for the induction of targeted protein degradation

Nobumoto Watanabe, PhD

RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, Bioprobe Application Research Unit, RIKEN Center for Sustainable Resource Science Unit Leader

Development of high sensitive array of the linkage-specific ubiquitin aptamers

Maiko Okada, PhD

Tokyo University of Technology, School of Bioscience and Biotechnology Assistant professor

Dissection of viral budding through creation of ubiquitin technology

Jun Arii, DVM, PhD

Division of Clinical Virology, Center for Infectious diseases, Kobe University Graduate School of Medicine Associate Professor

Development of chemical probes for ubiquitinated proteins and their linkage patterns

Yukihiro Itoh, PhD

Department of Complex Molecular Chemistry The Institute of Scientific and Industrial Research, Osaka University Associate Professor

Spatiotemporal regulation of proteolysis based on photoreversible protein labeling technology

Shin Mizukami, PhD

Tohoku University, Institute of Multidisciplinary Research for Advanced Materials Professor

Ubiquitin-selective recognition and labeling based on macromolecular self-assembly

Taku Kitanosono, PhD

The University of Tokyo, Synthetic Organic Chemistry Laboratory Assistant Professor

Development of random loop-stapling peptide for ubiquitin code analyses

Yousuke Takaoka, PhD

Department of Chemistry, Graduate School of Science, Tohoku University Associate Professor

Development of small chemical compounds that specifically inhibited USP-family deubiquitinating enzymes.

Hirotaka Takahashi, PhD

Division of Cell-free Sciences, Proteo-Science Center, Ehime University. Senior Assistant Professor.