New frontier for ubiquitin biology driven by chemo-technologies | Publicly Offered Research

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Publicly Offered Research

Research group A01: Elucidation of ubiquitin functions by chemo-technologies

Physicochemical properties and molecular regulation of TRIM-type ubiquitin ligases
Shigetsugu Hatakeyama, MD, PhD	Department of Biochemistry, Faculty of Medicine, Hokkaido University Professor

Deciphering ribosome-ubiquitin code using chemo-technologies and its control
Yoshitaka Matsuo, PhD	Institute of Medical Science, The University of Tokyo, Division of RNA and Gene regulation Associate Professor

Development of therapeutic strategies for various diseases by regulation of the cell death/survival balance using ubiquitin chemo-technologies
Atsushi Matsuzawa, PhD	Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University Professor

Deciphering ubiquitin code using chemo-technologies and advanced proteomics
Atsuya Nishiyama, PhD	Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo Associate Professor

Elucidation of mechanisms underlying USP8 autoinhibition and development of USP8 inhibitors for Cushing's disease therapy
Toshiaki Fukushima, PhD	Tokyo Institute of Technology, Institute of Innovative Research Assistant Professor

Structural biology of branched ubiquitin chain recognition using enzymatic and chemical reactions
Yusuke Sato, PhD	Tottori University, Graduate School of Engineering, Laboratory of Structural Biology Senior Lecturer

Development of PROTAC-dependent interactome analysis method using proximity-dependent biotinylation enzyme
Satoshi Yamanaka, PhD	Ehime University, Proteo-Science Center, Division of Proteo-Interactome Assistant professor

Development and application of nanobody-based tools to monitor cellular dynamics of a target E3 ligase complex
Fumiyo Ikeda, DDS, PhD	Ubiquitin Biology Laboratory, Graduate School of Frontier Biosciences, Osaka University Professor

Elucidation of the new substrates for preemptive quality control system using chemo-technologies
Hiroyuki Kawahara, PhD	Tokyo Metropolitan University, Department of Biological Sciences Professor

Inhibition of disease pathogenesis using chemo-technologies targeting the linear ubiquitin chain-dynamics
Daisuke Oikawa, PhD	Department of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University Associate Professor

Integrative Comprehension of Vasculopathies Originating from Ubiquitin Anomaly, and Drug Development
Daisuke Morito, PhD	Showa University School of Medicine, Department of Biochemistry Associate Professor

Crosstalk analysis between ubiquitination and UBL3 modification by using UBL3 chemotechnology
Hiroshi Ageta, PhD	Fujita Health University, Center for Medical Science, Division for Therapies Against Intractable Diseases Lecturer

Development of agents regulating CFTR ubiquitination and application to CF drug discovery
Tsukasa Okiyoneda, PhD	Department of Biomedical Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University Professor

Research group A02: Development of ubiquitin chemo-technologies

Development of selective chemical tool box useful for analyses of the ubiquitin ligase substrates
Yousuke Takaoka, PhD	Graduate School of Science, Tohoku University, Laboratory of Organic Chemistry I Associate Professor

Development of a molecular tool for conditional control of cellular protein stability using a excisable degradation domain
Yusaku Miyamae, PhD	University of Tsukuba, Faculty of Life and Environmental Sciences Associate professor

Identification of ubiquitin ligase substrates and development of protein degradation method using evolutionary molecular engineering
Takuya Terai, Ph.D	Biomolecular Chemistry Laboratory, Department of Chemistry, School of Science, The University of Tokyo Associate Professor

Development of proteostasis modulators targeting the co-chaperon E3 ligase STUB1
Susumu Goyama, MD, PhD	Division of Molecular Oncology, Graduate School of Frontier Sciences,The University of Tokyo Principal Investigator, Professor

Development of ubiquitin-proteasome inducer on the G-quadruplex
Masayuki Tera, PhD	Institute of Engineering, Tokyo University of Agriculture and Technology Principal Investigator Associate Professor

Development of chemo-technology for controlling the spatial orientation of ubiquitin chains
Tetsuo Narumi, PhD	Shizuoka University, Graduate School of Integrated Science and Technology, Laboratory of Bioorganic Chemistry Principal Investigator, Associate Professor

Ubiquitin chemo-technology powered by chemical protein synthesis and molecular evolution
Gosuke Hayashi, PhD	Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University Associate Professor

Development of a protein knockdown method by bivalent DNA aptamers
Masashi Maekawa, PhD	Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University Assistant Professor

Development of small chemical compounds targeting deubiquitinating enzyme for regulation of the amounts of cellular proteins
Hirotaka Takahashi, PhD	Division of Cell-free Sciences, Proteo-Science Center, Ehime University Associate Professor

Development of fluorescence probe for proteasomal degradation process imaging and identification of novel proteasome inhibitors
Mitsuyasu Kawaguchi, Ph.D	Graduate School of Pharmaceutical Sciences, Nagoya City University, Lab of Bioorganic and Medicinal Chemistry Lecturer

Screening for small molecule competitors of the phosphorylated substrates ofβ-TrCP and their application for the induction of targeted protein degradation
Nobumoto Watanabe, PhD	Chemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science Temporary Emproyee