• 文部科学省
  • JSPS
  • 科研費
  • ユビキチンネオバイオロジー
  • ユビキチンネオバイオロジー
公募研究

Publicly Offered Research

Publicly Offered Research

Research group A01: Elucidation of ubiquitin functions by chemo-technologies

Physicochemical properties and molecular regulation of TRIM-type ubiquitin ligases

Shigetsugu Hatakeyama, MD, PhD Department of Biochemistry, Faculty of Medicine, Hokkaido University
Professor

Deciphering ribosome-ubiquitin code using chemo-technologies and its control

Yoshitaka Matsuo, PhD Institute of Medical Science, The University of Tokyo, Division of RNA and Gene regulation
Associate Professor

Development of therapeutic strategies for various diseases by regulation of the cell death/survival balance using ubiquitin chemo-technologies

Atsushi Matsuzawa, PhD Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
Professor

Deciphering ubiquitin code using chemo-technologies and advanced proteomics

Atsuya Nishiyama, PhD Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo
Associate Professor

Elucidation of mechanisms underlying USP8 autoinhibition and development of USP8 inhibitors for Cushing's disease therapy

Toshiaki Fukushima, PhD Tokyo Institute of Technology, Institute of Innovative Research
Assistant Professor

Structural biology of branched ubiquitin chain recognition using enzymatic and chemical reactions

Yusuke Sato, PhD Tottori University, Graduate School of Engineering, Laboratory of Structural Biology
Senior Lecturer

Development of PROTAC-dependent interactome analysis method using proximity-dependent biotinylation enzyme

Satoshi Yamanaka, PhD Ehime University, Proteo-Science Center, Division of Cell-Free Sciences
Postdoctoral researcher

Development and application of nanobody-based tools to monitor cellular dynamics of a target E3 ligase complex

Fumiyo Ikeda, DDS, PhD Kyushu University, Medical Institute of Bioregulation, Division of Inflammation and Proteostasis
Professor

Elucidation of the new substrates for preemptive quality control system using chemo-technologies

Hiroyuki Kawahara, PhD Tokyo Metropolitan University, Department of Biological Sciences
Professor

Inhibition of disease pathogenesis using chemo-technologies targeting the linear ubiquitin chain-dynamics

Daisuke Oikawa, PhD Department of Pathobiochemistry, Graduate School of Medicine, Osaka City University
Associate Professor

Integrative Comprehension of Vasculopathies Originating from Ubiquitin Anomaly, and Drug Development

Daisuke Morito, PhD Showa University School of Medicine, Department of Biochemistry
Associate Professor

Crosstalk analysis between ubiquitination and UBL3 modification by using UBL3 chemotechnology

Hiroshi Ageta, PhD Fujita Health University, Institute for Comprehensive Medical Science (ICMS), Division for Therapies Against Intractable Diseases
Lecturer

Development of agents regulating CFTR ubiquitination and application to CF drug discovery

Tsukasa Okiyoneda, PhD Department of Biomedical Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University
Professor

Research group A02: Development of ubiquitin chemo-technologies

Development of selective chemical tool box useful for analyses of the ubiquitin ligase substrates

Yousuke Takaoka, PhD Graduate School of Science, Tohoku University, Laboratory of Organic Chemistry I
Associate Professor

Development of a molecular tool for conditional control of cellular protein stability using a excisable degradation domain

Yusaku Miyamae, PhD University of Tsukuba, Faculty of Life and Environmental Sciences
Associate professor

Identification of ubiquitin ligase substrates and development of protein degradation method using evolutionary molecular engineering

Takuya Terai, Ph.D Biomolecular Chemistry Laboratory, Department of Chemistry, School of Science, The University of Tokyo
Project Associate Professor

Development of proteostasis modulators targeting the co-chaperon E3 ligase STUB1

Susumu Goyama, MD, PhD Division of Molecular Oncology, Graduate School of Frontier Sciences,The University of Tokyo
Principal Investigator, Professor

Development of ubiquitin-proteasome inducer on the G-quadruplex

Masayuki Tera, PhD Institute of Engineering, Tokyo University of Agriculture and Technology
Principal Investigator, Associate Professor

Development of chemo-technology for controlling the spatial orientation of ubiquitin chains

Tetsuo Narumi, PhD Shizuoka University, Graduate School of Integrated Science and Technology, Laboratory of Bioorganic Chemistry
Principal Investigator, Associate Professor

Ubiquitin chemo-technology powered by chemical protein synthesis and molecular evolution

Gosuke Hayashi, PhD Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University
Associate Professor

Development of a protein knockdown method by bivalent DNA aptamers

Masashi Maekawa, PhD Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University
Assistant Professor

Development of small chemical compounds targeting deubiquitinating enzyme for regulation of the amounts of cellular proteins

Hirotaka Takahashi, PhD Division of Cell-free Sciences, Proteo-Science Center, Ehime University
Associate Professor

Development of fluorescence probe for proteasomal degradation process imaging and identification of novel proteasome inhibitors

Mitsuyasu Kawaguchi, Ph.D Graduate School of Pharmaceutical Sciences, Nagoya City University, Lab of Bioorganic and Medicinal Chemistry
Lecturer

Screening for small molecule competitors of the phosphorylated substrates ofβ-TrCP and their application for the induction of targeted protein degradation

Nobumoto Watanabe, PhD RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, Bioprobe Application Research Unit, RIKEN Center for Sustainable Resource Science
Unit Leader