• 文部科学省
  • JSPS
  • 科研費
  • ユビキチンネオバイオロジー
  • ユビキチンネオバイオロジー
Publications

Publications

Publications

 

Original Articles

  1. Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, Yamagata A, Goto-Ito S, Mishima M, Ito Y, Oka T, Tanaka K, Fukai S.
    Structural insights into ubiquitin phosphorylation by PINK1.
    Sci. Rep. 8, 10382 (2018)
    PMID: 29991771
  2. Nishiyama Y, Fujii S, Makishima M, Hashimoto Y, Ishikawa M.
    Efficient lead finding, activity enhancement and preliminary selectivity control of nuclear receptor ligands bearing a phenanthridinone skeleton.
    Int. J. Mol. Sci. 19, 2090 (2018)
    PMID: 30021999
  3. Sohtome Y, Shimazu T, Barjau J, Fujishiro S, Akakabe M, Terayama N, Dodo K, Ito A, Yoshida M, Shinkai Y, Sodeoka M.
    Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses.
    Chem. Commun. 54, 9202-9205 (2018)
    PMID: 30063235
  4. Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi Y, Arata M, Ito A, Yoshida M, Nagaoka Y, Sumiyoshi T.
    Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.
    ACS Med. Chem. Lett. 9, 884-888 (2018)
    PMID: 30258535
  5. Shibata N, Shimokawa K, Nagai K, Ohoka N, Hattori T, Miyamoto N, Ujikawa O, Sameshima T, Nara H, Cho N, Naito M.
    Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.
    Sci. Rep. 8, 13549 (2018)
    PMID: 30202081
  6. Furuta H, Yoshihara H, Fukushima T, Yoneyama Y, Ito A, Worrall C, Girnita A, Girnita L, Yoshida M, Asano T, Komada M, Kataoka N, Chida K, Hakuno F, Takahashi SI.
    IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.
    Oncotarget 9, 33871-33883 (2018)
    PMID: 30338032
  7. Azuma Y, Imai H, Kawaguchi Y, Nakase I, Kimura H, Futaki S.
    Modular redesign of a cationic lytic peptide to promote the endosomal escape of biomacromolecules.
    Angew. Chem. Int. Ed. Engl. 57, 12771 (2018)
    PMID: 30101453
  8. Nakamoto Y, Pradipta AR, Mukai H, Zouda M, Watanabe Y, Kurbangalieva A, Ahmadi P, Manabe Y, Fukase K, Tanaka K.
    Expanding the applicability of the metal labeling of biomolecules by the RIKEN click reaction: A case study with Gallium-68 positron emission tomography.
    ChemBioChem. 19, 2055-2060 (2018)
    PMID: 30066425
  9. Wu W, Sahara K, Hirayama S, Zhao X, Watanabe A, Hamazaki J, Yashiroda H, Murata S.
    PAC1‐PAC2 proteasome assembly chaperone retains the core α4–α7 assembly intermediates in the cytoplasm.
    Genes to Cells 23, 839–848 (2018)
    PMID: 30133132
  10. Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL.
    Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.
    PLoS Comput. Biol. 14, e1006532 (2018)
    PMID: 30376562
  11. MacDuff DA, Baldridge MT, Qaqish AM, Nice TJ, Darbandi AD, Hartley VL, Peterson ST, Miner JJ, Iwai K, Virgin HW.
    HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection.
    J. Virol. 92, pii: e01368-18 (2018)
    PMID: 30209176
  12. Tanei T, Pradipta AR, Morimoto K, Fujii M, Arata M, Ito A, Yoshida M, Saigitbatalova E, Kurbangalieva A, Ikeda JI, Morii E, Noguchi S, Tanaka K.
    Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology.
    Adv. Sci. 6, 1801479 (2018)
    PMID: 30693189
  13. Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
    RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
    Cancer Sci. 109, 4003-4014 (2018)
    PMID: 30238564
  14. Sueoka T, Koyama K, Hayashi G, *Okamoto A.
    Chemistry-driven Epigenetic Investigation of Histone and DNA Modifications.
    Chem. Rec. 18, 1727-1744 (2018)
    PMID: 30070422
  15. Kamo N, Hayashi G, Okamoto A.
    Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation.
    Angew. Chem. Int. Ed. 57, 16533-16537 (2018)
    PMID: 30346110
    Highlighted inSYNFACTS 15, 0204 (2018)
  16. Tomita T, Hirayama S, Sakurai Y, Ohte Y, Yoshihara H, Saeki Y, Hamazaki J, Murata S.
    Specific modification of aged proteasomes revealed by tag-exchangeable knock-in mice.
    Mol. Cell Biol. 39, e00426-18 (2018)
    PMID: 30348842
  17. Shioi R, Toyota Y, Noguchi-Yachide T, Ishikawa M. Yamaguchi T, Makishima M, Hashimoto Y, Ohgane K.
    Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands.
    Heterocycles 97, 854-864 (2018)

 

Review Articles

  1. *Murata S, *Takahama Y, *Kasahara M, *Tanaka K.
    The immunoproteasome and thymoproteasome: functions, evolution and human disease.
    Nat. Immunol. 19, 923–931(2018)
    PMID: 30104634
  2. Koizumi S, Hamazaki J, *Murata S.
    Transcriptional regulation of the 26S proteasome by Nrf1.
    Proc. Jpn. Acad. Ser. B 94, 325–336 (2018)
    PMID: 30305478
  3. Robaa D, Monaldi D, Wössner N, Kudo N, Rumpf T, Schiedel M, Yoshida M, *Jung M.
    Opening the selectivity pocket in the human lysine deacetylase sirtuin2 - new opportunities, new questions.
    Chem. Rec. 18, 1701-1707 (2018)
    PMID: 29931800
  4. Sueoka T, Koyama K, Hayashi G, *Okamoto A.
    Chemistry-driven Epigenetic Investigation of Histone and DNA Modifications.
    Chem. Rec. 18, 1727-1744 (2018)
    PMID: 30070422

 

 

Original Articles

  1. Tomaru U, Konno S, Miyajima S, Kimoto R, Onodera M, Kiuchi S, Murata S, Ishizu A, Kasahara M.
    Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells.
    Cell Rep. 26, 639-651. e2 (2019)
    PMID: 3065037
  2. Wu M, Chang Y, Hu H, Mu R, Zhang Y, Qin X, Duan X, Li W, Tu H, Zhang W, Wang G, Han Q, Li A, Zhou T, Iwai K, Zhang X Li H.
    LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores.
    Nat. Commun. 10, 273 (2019)
    PMID: 30655516
  3. Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.
    Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments.
    Nat. Protoc. 14, 415-440 (2019)
    PMID: 30635653
  4. Izuta S, Yamaguchi S,* Kosaka T, *Okamoto A.
    Reversible and Photoresponsive Immobilization of Nonadherent Cells by Spiropyran-Conjugated PEG-Lipids.
    ACS Appl. Bio Mater. 2, 33-38 (2019)
  5. Kawaguchi Y, Ise S, Azuma Y, Takeuchi T, Kawano K, Le TK, Ohkanda J, Futaki S.
    Dipicolylamine/metal complexes that promote direct cell-membrane penetration of octaarginine.
    Bioconjug. Chem. 30, 454-460 (2019)
    PMID: 30428256
  6. Ikeuchi K, Tesina P, Matsuo Y, Sugiyama T, Cheng J, Saeki Y, Tanaka K, Becker T, Beckmann R, Inada T.
    Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.
    EMBO J. 38, e100276 (2019)
    PMID: 30609991
  7. Hitachi K, Nakatani M, Takasaki A, Ouchi Y, Uezumi A, Ageta H, Inagaki H, Kurahashi H, Tsuchida K.
    Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation.
    EMBO Rep. 20, e47468 (2019)
    PMID: 30622218
  8. Ohoka N, Ujikawa O, Shimokawa K, Sameshima T, Shibata N, Hattori T, Nara H, Cho N, Naito M.
    Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER).
    Chem. Pharm. Bull. 67, 203-209 (2019)
    PMID: 30369550
  9. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.
    A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.
    J. Biol. Chem. 294, 2988-2996 (2019)
    PMID: 30610116
  10. Otsubo R, Mimuro H, Ashida H, Hamazaki J, Murata S, Sasakawa C.
    Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation.
    Cell. Microbiol. 21, e12974 (2019)
    PMID: 30414351
  11. Hayashi G, Yanase M, Nakatsuka Y, Okamoto A.
    Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold.
    Biomacromolecules 20, 1246-1253 (2019)
    PMID: 30677290
  12. Ling F, Bradshaw E, Yoshida M.
    Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1.
    Sci. Rep. 9, 5433 (2019)
    PMID: 30931958
  13. Takahashi T, Minami S, Tajima K, Tsuchiya Y, Sakai N, Suga K, Hisanaga S, Obayashi N, Fukuda M, Kawahara H.
    Cytoplasmic control of Rab-family small GTPases through BAG6.
    EMBO Rep. 20, e46794 (2019)
    PMID: 30804014
  14. Ishii N, Walinda E, Iwakawa N, Morimoto D, Iwai K, Sugase K, Shirakawa M.
    NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin.
    Biomol. NMR Assign. 13, 149-153 (2019)
    PMID: 30569274
  15. Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y.
    Rational design of novel amphipathic antimicrobial peptides focused on distribution of cationic amino acid residues.
    MedChemComm 10,896-900 (2019)
    PMID: 31303986
  16. Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H.
    Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
    J. Med. Chem. 62, 3407-3427 (2019)
    PMID: 30883102
  17. Demizu S, Asaka N, Kawahara H, Sasaki E.
    TAS-203, an oral phosphodiesterase 4 inhibitor, exerts anti-inflammatory activities in a rat airway inflammation model.
    Eur. J. Pharmacol. 849, 22-29 (2019)
    PMID: 30716315
  18. Takahashi TS, Sato Y, Yamagata A, Goto-Ito S, Saijo M, Fukai S.
    Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.
    Nucleic Acids Res. 47, 3784-3794 (2019)
    PMID: 30753618
  19. Yanase M, Nakatsu K, Cardos C J, Konda Y, Hayashi G, Okamoto A.
    Cysteinylprolyl Imide (CPI) Peptide: A Highly Reactive and Easily Accessible Crypto-thioester for Chemical Protein Synthesis.
    Chem. Sci. 10, 5967-5975 (2019)
    PMID: 31360403
  20. *Yamaguchi S, Higashi K, Azuma T, *Okamoto A.
    Supramolecular Polymeric Hydrogels for Ultrasound-guided Protein Release.
    Biotechnol. J. 14, 1800530 (2019)
    PMID: 30810275
  21. Shu K, Iwamoto N, Honda K, Kondoh Y, Hirano H, Osada H, Ohno H, Fujii N, Oishi S.
    Development of mirror-image screening systems for XIAP BIR3 domain inhibitors.
    Bioconjug. Chem. 30, 1395-1404 (2019)
    PMID: 30888797
  22. Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H.
    Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation.
    iScience 15, 95-108 (2019)
    PMID: 31055217
  23. Bai M, Zhao X, Sahara K, Ohte Y, Hirano Y, Kaneko T, Yashiroda H, Murata S.
    In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals.
    Biomolecules 9, E213 (2019)
    PMID: 31159305
  24. Qi Y, Zhao X, Chen J, Pradipta AR, Wei J, Ruan H, Zhou L, Hsung R P, Tanaka K.
    In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6.
    Biosci. Biotechnol. Biochem. 83, 1011-1026 (2019)
    PMID: 31074699
  25. Mashita T, Kowada T, Takahashi H, Matsui T, Mizukami S.
    Light-wavelength-based Quantitative Control of Dihydrofolate Reductase Activity Using Photochromic Isostere of Inhibitor.
    ChemBioChem 20, 1382–1386 (2019)
    PMID: 30656808
  26. Sekiguchi Y, Yamada M, Noguchi T, Noomote C, Tsuchida M, Kudoh Y, Hirata Y, Matsuzawa A.
    The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells.
    J. Toxicol. Sci. 44, 435-440 (2019)
    PMID: 31168030
  27. Förster T, Shang E, Shimizu K, Sanada E, Schölermann B, Hübecker M, Hahne G, Pascual Lopez Alberca M, Janning P, Watanabe N, Sievers S, Giordanetto F, Shimizu T, Ziegler S, Osada H Waldmann, H.
    2-Sulfonylpyrimidines target the kinesin HSET via cysteine alkylation.
    Eur. J. Org. Chem. 2019, 5486-5496 (2019)
  28. Koyano F, Yamano K, Kosako H, Tanaka K. 2019, 5486-5496 (2019), Matsuda N.
    Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL.
    J. Biol. Chem. 294, 10300-10314 (2019)
    PMID: 31110043
  29. Arii J, Takeshima K, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
    Roles of the interhexamer Contact Site for Hexagonal Lattice Formation of the Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication.
    J. Virol. 93, e00498-19 (2019)
    PMID: 31043535
  30. Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shin-Ya K, Kimura H, Yoshida M, Murakami S, Kondo Y.
    Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.
    J. Biochem. 166, 41-50 (2019)
    PMID: 30690451
  31. Misawa T, Ohoka N, Oba M, Yamashita H, Tanaka M, Naito M, Demizu Y.
    Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery.
    Chem. Commun. 55, 7792-7795 (2019)
    PMID: 31210205
  32. Usami K, Xiao K, Okamoto A.*
    Efficient Ketose Production by Hydroxyapatite Catalyst in a Continuous Flow Module.
    ACS Sustainable Chem. Eng. 7, 3372-3377 (2019)
  33. Mitsui E, Yoshida S, Shinoda Y, Matsumori Y, Tsujii H, Tsuchida M, Wada S, Hasegawa M, Ito A, Mino K, Onuki T, Yoshida M, Sasaki R, Mizukami T.
    Identification of ryuvidine as a KDM5A inhibitor.
    Sci. Rep. 9, 9952 (2019)
    PMID: 31289306
  34. Hayashishita M, Kawahara H, Yokota N.
    BAG6 deficiency induces mis-distribution of mitochondrial clusters under depolarization.
    FEBS Open Bio. 9, 1281-1291 (2019)
    PMID: 31125507
  35. Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, Iwasaki S.
    Genome-wide survey of ribosome collision.
    bioRxiv
  36. Takase S, Kurokawa R, Kondoh Y, Honda K, Suzuki T, Kawahara T, Ikeda H, Dohmae N, Osada H, Shin-Ya K, Kushiro T, Yoshida M, Matsumoto K.
    Mechanism of action of prethioviridamide, an anticancer ribosomally synthesized and post-translationally modified peptide with a polythioamide structure.
    ACS Chem. Biol. 14, 1819-1828 (2019)
    PMID: 31365229
  37. Arata Y, Watanabe A, Motosugi R, Iemura S, Natsume T, Mukai K, Taguchi T, Hirayama S, Hamazaki J, Murata S.
    FAM48A mediates compensatory autophagy induced by proteasome impairment.
    Genes to Cells 24, 559–568 (2019)
    PMID: 31210371
  38. Sasaki K, Himeno A, Nakagawa T, Sasaki Y, Kiyonari H, Iwai, K.
    Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
    Nat. Commun. 10, 3878 (2019)
    PMID: 31462647
  39. Yoshida K, Kondoh Y, Iwahashi F, Nakano T, Honda K, Nagano E, Osada H.
    Abscisic acid derivatives with different alkyl chain lengths activate distinct abscisic acid receptor subfamilies.
    ACS Chem. Biol. 14, 1964-1971 (2019)
    PMID: 31497942
  40. Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T.
    The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.
    J. Biol. Chem. 294, 14135–14148 (2019)
    PMID: 31366726
  41. Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S.
    A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.
    J. Biol. Chem. 294, 14562-14573 (2019)
    PMID: 31371451
  42. Masuda Y, Saeki Y, Arai N, Kawai H, Kukimoto I, Tanaka K, Masutani C.
    Stepwise multipolyubiquitantion of p53 by the E6AP-E6 ubiquitin ligase complex.
    J. Biol. Chem. 294, 14860-14875 (2019)
    PMID: 31492752
  43. Takeshima K, Arii J (contributed equally), Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
    Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication.
    J. Virol. 93, e01290-19 (2019)
    PMID: 31391274
  44. Kamo N, Hayashi G, Okamoto A.
    Chemical Synthesis of Cys-Containing Protein via Chemoselective Deprotection with Different Palladium Complexes.
    Org. Lett. 21, 8378-8382 (2019)
    PMID: 31560553
  45. Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H.
    p63 is a cereblon substrate involved in thalidomide teratogenicity.
    Nat. Chem. Biol. 15, 1077-1084 (2019)
    PMID: 31591562
  46. Yokosawa T, Yamada M, Noguchi T, Suzuki S, Hirata Y, Matsuzawa A.
    Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation.
    J. Antibiotics 72, 848-852 (2019)
    PMID: 31371783
  47. Jarzebska N A, Yamaguchi S,* Izuta S, Kosaka T, Yamahira S, Nagamune T, Okamoto A.*
    Photo-responsive materials with strong cell trapping ability for light-guided manipulation of nonadherent cells.
    Biomater. Sci. 7, 4514-4518 (2019)
    PMID: 31602442
  48. Chulakova D R, Pradipta AR, Lodochnikova OA, Kuznetsov DR, Bulygina KS, Smirnov IS, Usachev KS, Latypova LZ, Kurbangalieva AR, Tanaka K.
    Facile access to optically active 2,6-dialkyl-1,5-diazacyclooctanes.
    Chem. Asian J. 14, 4048-4054 (2019)
    PMID: 31381243
  49. Goto C, Hirano M, Hayashi K, Kikuchi Y, Hara-Kudo Y, Misawa T, Demizu Y.
    Development of amphipathic antimicrobial peptide foldamers based on Magainin 2 sequence.
    ChemMedChem 14,1911-1916 (2019)
    PMID: 31667994
  50. Kamada Y, Fukuda R, Okiyoneda T.
    ELISA Based Protein Ubiquitylation Measurement.
    Bio-protocol 9, e3430 (2019)
  51. Yang N, Liu S, Qin T, Liu X, Watanabe N, Mayo KH, Li J, Li X.
    SUMO3 Modification by PIAS1 Modulates Androgen Receptor Cellular Distribution and Stability.
    Cell Commun. Signal. 17, 153 (2019)
    PMID: 31752909
  52. Nomura S, Takahashi H, Suzuki J, Kuwahara M, Yamashita M, Sawasaki T.
    Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro.
    Sci. Rep. 9,17335 (2019)
    PMID: 31758034
  53. Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin AC, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y.
    Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.
    Cell Rep. 29, 2901-2916.e6 (2019)
    PMID: 31775054
  54. Abe T, Shizu R, Sasaki T, Shimizu Y, Hosaka T, Kodama S, Matsuzawa A, Yoshinari K.
    Functional interaction between PXR and YAP in xenobiotic-dependent liver hypertrophy and drug metabolism.
    J. Pharmacol. Exp. Ther. 371, 590-601(2019)
    PMID: 31533970
  55. Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N.
    Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.
    EMBO Rep. 20, e47728 (2019)
    PMID: 31602805
  56. Ohoka N, Tsuji G, Shoda T, Fujisato T, Kurihara M, Demizu Y, Naito M.
    Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins.
    ACS Chem. Biol. 14, 2822-2832 (2019)
    PMID: 31580635
  57. Kwong MMY, Lee JW, Samian MR, Watanabe N, Osada H, Ong EBB.
    Comparison of microplate-and bottle-based methods to age yeast for chronological life span assays.
    J. Microbiol. Methods. 167 105743 (2019)
    PMID: 31629019
  58. Arata Y, Watanabe A, Motosugi R, Murakami R, Goto T, Hori S, Hirayama S, Hamazaki J, Murata S.
    Defective induction of the proteasome associated with T‐cell receptor signaling underlies T‐cell senescence.
    Genes to Cells 24, 801–813 (2019)
    PMID: 31621149
  59. Sato Y, Tsuchiya H, Yamagata A, Okatsu K, Tanaka, K, Saeki Y, Fukai S.
    Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4.
    Nat. Commun. 10, 5708 (2019)
    PMID: 31836717
  60. Imoto T, Muramatsu M, Miyasaka H, Mizukami S, Kikuchi K.
    Improvement in Photostability of Fluorescein by Lanthanide Ions based on Energy Transfer-Based Triplet State Quenching
    Chem. Lett. 48, 1181–1184 (2019)

 

Review Articles

  1. *Yoshida M.
    Recent advances in target identification of bioactive natural products.
    Biosci. Biotechnol. Biochem. 83, 1-9 (2019)
    PMID: 30343630
  2. Ohtake F, Tsuchiya H, Tanaka K, *Saeki Y.
    Methods to measure ubiquitin chain length and linkage.
    Methods Enzymol. 618, 105-133 (2019)
    PMID: 30850048
  3. Yoshida Y, Saeki Y, Tsuchiya H, *Tanaka K.
    TR-TUBE system: Method for detecting ubiquitination activity and identifying ubiquitinated substrates
    Methods Enzymol. 618, 135-147 (2019)
    PMID: 30850049  
  4. Shibata N, Ohoka N, Hattori T, *Naito M.
    Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein.
    Chem. Pharm. Bull. 67, 165-172 (2019)
    PMID: 30827996
  5. *Naito M, Ohoka N, Shibata N.
    SNIPERs-Hijacking IAP activity to induce protein degradation.
    Drug Discov. Today: Technol. 31, 35-42 (2019)
    PMID: 31200857
  6. Motosugi R, *Murata S.
    Dynamic Regulation of Proteasome Expression.
    Front. Mol. Biosci. 6, 30 (2019)
    PMID: 31119134
  7. *Inada T.
    The mechanism for recycling tRNAs on stalled ribosomes.
    Nat. Struc. Mol. Biol. 26, 340-342 (2019)
    PMID: 31011210
  8. Wei W, Rasul A, Sadiqa A, Sarfraz I, Hussain G, Nageen B, Liu X, Watanabe N, Selamoglu Z, Ali M, *Li X, *Li J.
    Curcumol: From Plant Roots to Cancer Roots.
    Int. J. Biol. Sci. 15, 1600-1609 (2019)
    PMID: 31360103
  9. Asatsuma-Okumura T, Ito T (co-1st author), *Handa H.
    Molecular mechanisms of cereblon-based drugs.
    Pharmacol. Ther. 202, 132-139. (2019)
    PMID: 31202702
  10. *Yashiroda Y, Yoshida M.
    Intraspecies cell-cell communication in yeast.
    FEMS Yeast Res. 19, pii: foz071 (2019)
    PMID: 31688924
  11. *Naito M, Ohoka N, Shibata N, Tsukumo Y.
    Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs.
    Front. Chem. 7, 849 (2019)
    PMID: 31921772
  12. *Inada T.
    The proteasome's balancing act.
    Nat. Plants 5,1203-1204 (2019)
    PMID: 31740771
  13. Ageta H, *Tsuchida K.
    Post-translational modification and protein sorting to small extracellular vesicles including exosomes by ubiquitin and UBLs.
    Cell. Mol. Life Sci. 76,4829-4848 (2019)
    PMID: 31363817

 

 

Original Articles

  1. Yamashita H, Tomoshige S, Nomura S, Ohgane K, Hashimoto Y, Ishikawa M.
    Application of Protein Knockdown Strategy Targeting β-Sheet Structure to Multiple Disease-associated Polyglutamine Proteins.
    Bioorg. Med. Chem. 28, 115175 (2020)
    PMID: 31767406
  2. Lodochnikova OA, Chulakova DR, Gerasimova DP, Litvinov IA, Pradipta AR, Tanaka K, Kurbangalieva AR.
    Stereochemical features of the crystallization of eight-membered 1,5-diazaheterocycles with chiral aminoindanol fragments at nitrogen atoms.
    J. Struct. Chem. 61, 119-125 (2020)
  3. Mimami S, Yokota N, Kawahara H.
    BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
    Biol. Open 9, bio047324 (2020)
    PMID: 31911483
  4. Mishima Y, Brueckner L, Takahashi S, Kawakami T, Otani J, Shinohara A, Takeshita K, Garvilles RG, Watanabe M, Sakai N, Takeshima H, Nachtegael C, Nishiyama A, Nakanishi M, Arita K, Nakashima K, Hojo H, Suetake I.
    Enhanced processivity of Dnmt1 by monoubiquitinated histone H3.
    Genes Cells 25, 22-32 (2020)
    PMID: 31680384
  5. Yamada M, Suzuki M, Noguchi T, Yokozawa T, Sekiguchi Y, Mutoh N, Toyama T, Hirata Y, Hwang GW, Matsuzawa A.
    The antibiotic cefotaxime works as both an activator of Nrf2 and an inducer of HSP70 in mammalian cells.
    BPB Rep. 3, 16-21 (2020)
  6. Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y.
    Stress- and ubiquitylation-dependent phase separation of the proteasome.
    Nature 578, 296-300 (2020)
    PMID: 32025036
    Highlighted in Cell Res
    EurekAlert!
    Faculty Opinions
  7. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.
    Measurement of ATPase activity of valosin-containing protein/p97.
    Bio-protocol 10, e3516 (2020)
  8. Suvarna K, Honda K, Muroi M, Kondoh Y, Watanabe N, Osada H.
    Identification of target protein for bio-active small molecule using photo-cross linked beads and MALDI-TOF mass spectrometry.
    Bio-protocol 10, e3517 (2020)
  9. Hirata Y, Inoue A, Suzuki S, Takahashi M, Matsui R, Kono N, Noguchi T, Matsuzawa A.
    trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop.
    Sci. Rep. 10, 2743 (2020)
    PMID: 32066809
  10. Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
    Targeted protein degradation by chimeric compounds using hydrophobic E3 ligands and adamantane moiety.
    Pharmaceuticals 13, E34 (2020)
    PMID: 32106507
  11. Brazee PL, Morales-Nebreda L, Magnani ND, Garcia JG, Misharin AV, Ridge KM, Budinger GRS, Iwai K, Dada LA, Sznajder, JI.
    Linear ubiquitin assembly complex regulates lung epithelial-driven responses during influenza infection.
    J. Clin. Invest. 130, 1301-1314 (2020)
    PMID: 31714898
  12. Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, Tamura N, Hatanaka A, Hirose S, Katayama H, Tani M, Kubo Y, Hamazaki J, Hamakubo T, Watanabe A, Murata S, Kobayashi A.
    NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.
    Mol. Cell. Biol. 40,e597-19 (2020)
    PMID: 32123008
  13. Tateno S, Iida M, Fujii S, Suwa T, Katayama M, Tokuyama H, Yamamoto J, Ito T, Sakamoto S, Handa H, Yamaguchi Y.
    Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide.
    Sci. Rep. 10,4012 (2020)
    PMID: 32132601
  14. Nishiyama A, Mulholland C, Bultmann S, Kori A, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H, Nakanishi M.
    Two distinct modes of DNMT1 recruitment ensure the stable maintenance DNA methylation.
    Nat. Commun. 11, 1222 (2020)
    PMID: 32144273
    Faculty Opinions
  15. Shibata N, Ohoka N, Tsuji G, Demizu Y, Akiyama T, Naito M.
    Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.
    Oncogene 39,3867-3878 (2020)
    PMID: 32203161
  16. Arafiles JVV, Hirose H, Akishiba M, Tsuji S, Imanishi M, Futaki S.
    Stimulating macropinocytosis for intracellular nucleic acid and protein delivery: a combined strategy with membrane-lytic peptides to facilitate endosomal escape.
    Bioconjug. Chem. 31, 547-553 (2020)
    PMID: 32017537
  17. Matsuo Y, Tesina P, Nakajima S, Mizuno M, Endo A, Buschauer R, Cheng J, Shounai O, Ikeuchi K, Iwasaki S, Saeki Y, Becker T, Beckmann R, Inada T.
    RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
    Nat. Stuct. Mol. Biol. 27, 323-332 (2020)
    PMID: 32203490
  18. Takaoka Y, Miyagawa S, Nakamura A, Egoshi S, Tsukiji S, Ueda M.
    Hoechst-tagged Fluorescein Diacetate for the Fluorescence Imaging-based Assessment of Stomatal Dynamics in Arabidopsis thaliana.
    Sci. Rep. 10, 5333 (2020)
    PMID: 32210301
  19. Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunaga F, Takahashi H, Sawasaki T.
    Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
    Biochem. Biophys. Res. Commun. 524, 1-7 (2020)
    PMID: 31898971
  20. Naito S, Fukushima T, Endo A, Denda K, Komada M.
    Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.
    FEBS Lett. 594,1778-1786 (2020)
    PMID: 32162334
  21. Tsuchida M, Yokozawa T, Noguchi T, Shimada T, Yamada M, Sekiguchi Y, Hirata Y, Matsuzawa A.
    Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin.
    J. Toxicol. Sci. 45, 219-226 (2020)
    PMID: 32238696
  22. Morihiro K, Okamoto A.
    A highly constrained nucleic acid analog based on α-L-threosamine.
    Nucleosides Nucleotides Nucleic Acids 39, 270-279 (2020)
    PMID: 31530088
  23. Luong NC, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, Noguchi T, Matsuzawa A, Kumagai Y.
    Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B.
    J. Toxicol. Sci. 45, 349-363 (2020)
    PMID: 32493877
  24. Wang L, Liu S, Xu J, Watanabe N, Di J, Wei W, Mayo KH, Li J, Li X.
    A traditional Chinese Medicine, YXQN, Reduces Amyloid-induced Cytotoxicity by Inhibiting Aβ42 Aggregation and Fibril Formation.
    Curr. Pharm. Des. 26, 780-789 (2020)
    PMID: 32031066
  25. Chen J, Morihiro K, Fukui D, Guo L, Okamoto A.
    Live-Cell Sensing of Telomerase Activity Using Hybridization-Sensitive Fluorescent Oligonucleotide Probes.
    ChemBioChem 21, 1022-1027 (2020)
    PMID: 31840916
  26. Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
    Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
    Commun. Biol. 3, 163 (2020)
    PMID: 32246052
  27. Sugawara E, Kato M, Kudo Y, Lee W, Hisada R, Fujieda Y, Oku K, Bohgaki T, Amengual O, Yasuda S, Onodera T, Hatakeyama S, Atsumi T.
    Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts.
    Autophagy 16, 946-955 (2020)
    PMID: 31486697
  28. Pradipta AR, Tanei T, Morimoto K, Shimazu K, Noguchi S, Tanaka K.
    Emerging technologies for real-time intraoperative margin assessment in future breast-conserving surgery.
    Adv. Sci. 7, 1901519 (2020)
    PMID: 32382473
  29. Buschauer R, Matsuo Y (co-1st author), Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Gilmozzi A, Berninghausen O, Becker T, Coller J, Inada T, Beckmann R.
    The Ccr4-Not complex monitors the translating ribosome for codon optimality.
    Science 368, 6448 (2020)
    PMID: 32299921
  30. Sugawara E, Kato M, Kudo Y, Lee W, Hisada R, Fujieda Y, Oku K, Bohgaki T, Amengual O, Yasuda S, Onodera T, Hatakeyama S, Atsumi T.
    Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts,
    Autophagy 16, 946-955 (2020)
    PMID: 31486697
  31. Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, Iwasaki S.
    Genome-wide survey of ribosome collision.
    Cell Rep. 31,107610 (2020)
    PMID: 32375038
  32. Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O.
    The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis.
    J. Am. Acad. Dermatol. AOP (2020)
    PMID: 32439465
  33. Sako K, Futamura Y, Shimizu T, Matsui A, Hirano H, Kondoh Y, Muroi M, Aono H, Tanaka M, Honda K, Shimizu K, Kawatani M, Nakano T, Osada H, Noguchi K, Seki M.
    Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.
    Sci. Rep. 10, 8691 (2020)
    PMID: 32457324
  34. Fuseya Y, Fujita H, Kim M, Ohtake F, Nishide A, Sasaki K, Saeki Y, Tanaka K, Takahashi R, Iwai K.
    The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.
    Nat. Cell Biol. 22, 663-673 (2020)
    PMID: 32393887
  35. Tamemoto N, Akishiba M, Sakamoto K, Kawano K, Noguchi H, Futaki S.
    Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules.
    Mol. Pharm. 17, 2175-2185 (2020)
    PMID: 32352304
  36. Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, Sawasaki T.
    A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors.
    Biomedicines 8, 152 (2020)
    PMID: 32512835
  37. Sakamoto K, Akishiba M, Iwata T, Murata K, Mizuno S, Kawano K, Imanishi M, Sugiyama F, Futaki S.
    Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules.
    Angew. Chem. Int. Ed. Engl. AOP (2020)
    PMID: 32557993
  38. Nakatsu K, Yanase M, Hayashi G, Okamoto A.
    Fmoc-Compatible and C-terminal-Sequence-Independent Peptide Alkyl Thioester Formation Using Cysteinylprolyl Imide.
    Org. Lett. 22, 4670-4674 (2020)
    PMID: 32484687
  39. Fuseya Y, Fujita H, Kim M, Ohtake F, Nishide A, Sasaki K, Saeki Y, Tanaka K, Takahashi R, Iwai K.
    The HOIL-1L ligase modulates immune signaling and cell death via mono-ubiquitination of LUBAC.
    Nat. Cell Biol. 22, 663-673 (2020)
    PMID: 32393887
  40. Jo T, Nishikori M, Kogure Y, Arima H, Sasaki K, Sasaki Y, Nakagawa T, Iwai F, Momose S, Shiraishi A, Kiyonari H, Kagaya N, Onuki T, Shin-Ya K, Yoshida M, Kataoka K, Ogawa S, Iwai K, Takaori-Kondo A.
    LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells.
    Blood 136, 684–697 (2020)
    PMID: 32325488
  41. Kori S, Jimenji T, Ekimoto T, Sato M, Kusano F, Oda T, Unoki M, Ikeguchi M, Arita K.
    Serine 298 phosphorylation in linker 2 of UHRF1 regulates ligand-binding property of its tandem Tudor domain.
    J. Mol. Biol. 432, 4064-4078 (2020)
    PMID: 32428527
  42. Pradipta A R, Chang T C, Tanaka K.
    Enantioselective synthesis of cyclic and linear diamines by iminocycloaddition.
    Chirality 32, 1160-1168 (2020)
    PMID: 32621328
  43. Yamaguchi S, Takagi R, Hosogane T, Ohashi Y, Sakai Y, Sakakihara S, Iino R, Tabata K, Noji H, Okamoto A.
    Single cell array enclosed with a photodegradable hydrogel in microwells for image-based cell classification and selective photorelease of cells.
    ACS Appl. Bio Mater. 3,9, 5887–5895 (2020)
  44. Matsuura Y, Noguchi A, Yokota N, Kawahara H.
    Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster.
    J. Biochem. 168,477-489 (2020)
    PMID: 32687160
  45. Suzuki G, Imura S, Hosokawa M, Katsumata R, Nonaka T, Hisanaga SI, Saeki Y, Hasegawa M.
    α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome.
    eLife 9, e56825 (2020)
    PMID: 32697196
  46. Hashimoto E, Okuno S, Hirayama S, Arata Y, Goto T, Kosako H, Hamazaki J, Murata S.
    Enhanced O-GlcNAcylation mediates cytoprotection under proteasome impairment by promoting proteasome turnover in cancer cells.
    iScience 23,101299 (2020)
    PMID: 32634741
  47. Yokoo H, Ohoka N, Naito M, Demizu Y.
    Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.
    Bioorg. Med. Chem. 28,115595 (2020)
    PMID: 32631565
  48. Wang L, Liu S, Xu J, Watanabe N, Mayo KH, Li J, Li X.
    Emodin inhibits aggregation of amyloid-β peptide 1-42 and improves cognitive deficits in Alzheimer's disease transgenic mice.
    J. Neurochem. AOP (2020)
    PMID: 32799401
  49. Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M.
    Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.
    ACS Chem. Biol. 15, 2195-2204 (2020)
    PMID: 32584541
  50. Kawamura T, Futamura Y, Shang E, Muroi M, Janning P, Ueno M, Wilke J, Takeda S, Kondoh Y, Ziegler S, Watanabe N, Waldmann H, Osada H.
    Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics.
    Biosci. Biotech. Biochem. 84, 2484-2490 (2020)
    PMID: 32867616
  51. Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, Matsuda N.
    Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy.
    J. Cell Biol. 219, e201912144 (2020)
    PMID: 32556086
  52. Kondo T, Iwatani Y, Matsuoka K, Fujino T, Umemoto S, Yokomaku Y, Ishizaki K, Kito S, Sezaki T, Hayashi G, Murakami H.
    Antibody-like proteins that capture and neutralize SARS-CoV-2.
    Sci. Adv. 6, eabd3916 (2020)
    PMID: 32948512
  53. Yamamoto J, Suwa T, Murase Y, Tateno S, Mizutome H, Asatsuma-Okumura T, Shimizu N, Kishi T, Momose S, Kizaki M, Ito T, Yamaguchi Y, Handa H.
    ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells.
    Nat. Chem. Biol. 16, 1208-1217 (2020)
    PMID: 32958952
  54. Kowada T, Watanabe T, Amagai Y, Liu R, Yamada M,Takahashi H, Matsui T, Inaba K, Mizukami S.
    Quantitative imaging of labile Zn2+ in the Golgi apparatus using a localizable small-molecule fluorescent probe
    Cell Chem. Biol. AOP(2020)
    PMID: 32997976
  55. Radwan MO, Ciftci HI, Ali TFS, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Fujita M, Otsuka M.
    Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
    Bioorg. Med. Chem. Lett. 30,127458 (2020)
    PMID: 32755678
  56. Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.
    A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.
    Biosci. Biotechnol. Biochem. 84,2113-2120 (2020)
    PMID: 32640867
  57. Ogata M, Hayashi G, Ichiu A, Okamoto A.
    L-DNA-tagged fluorescence in situ hybridization for highly sensitive imaging of RNAs in single cells.
    Org. Biomol. Chem. 18,8084-8088 (2020)
    PMID: 33001106
  58. Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S.
    A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
    Commun. Biol. 3,592 (2020)
    PMID: 33082525
  59. Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.
    Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.
    Environ. Pollut. 266, 115179 (2020)
    PMID: 32717636
  60. Pan Y, Zhao Y, Kuang R, Liu H, Sun D, Mao T, Jiang K, Yang X, Watanabe N, Mayo KH, Lin Q, Li J.
    Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion.
    Mater. Sci. Eng., C 116, 111158 (2020)
    PMID: 32806272
  61. Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, *Goto Y, *Yoshida M.
    Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.
    Nat. Chem. Biol. AOP (2020)
    PMID: 33168978

 

Review Articles

  1. *Itoh Y.
    Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches.
    Chem. Pharm. Bull. 68, 34-45 (2020)
    PMID: 31902900
  2. Takaoka Y, Hayashi K, Suzuki K, Azizah IN, * Ueda M.
    A Fluorescence Anisotropy-Based Comprehensive Method for the In Vitro Screening of COI1-JAZs Agonists and Antagonists.
    Methods Mol. Biol. 2085, 145-160 (2020)
    PMID: 31734923
  3. Ito T, *Handa H.
    Molecular mechanisms of thalidomide and its derivatives.
    Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 96,189-203 (2020)
    PMID: 32522938
  4. *Inada T.
    Quality controls induced by aberrant translation.
    Nucleic Acids Res. 48, 1084-1096 (2020)
    PMID: 31950154
  5. *Matsuda N, Yamano K.
    Two sides of a coin: physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin.
    Neurosci. Res. AOP (2020)
    PMID: 32201358
  6. Fukuda R, *Okiyoneda T.
    Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitylation as a Novel Pharmaceutical Target for Cystic Fibrosis.
    Pharmaceuticals(Basel) 13,75 (2020)
    PMID: 32331485
  7. *Ishikawa M, Tomoshige S, Demizu Y, Naito M.
    Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs.
    Pharmaceuticals 13,74 (2020)
    PMID: 32326273
  8. Asatsuma-Okumura T, *Ito T, Handa H.
    Molecular Mechanisms of the Teratogenic Effects of Thalidomide.
    Pharmaceuticals 96,189-203 (2020)
    PMID: 32414180
  9. Oikawa D, Sato Y, Ito H, *Tokunaga F.
    Linear ubiquitin code: Its writer, erasers, decoders, inhibitors, and implications in disorders.
    Int. J. Mol. Sci. 21,E3381, 2020.
    PMID: 32403254
  10. Tomoshige S, *Ishikawa M.
    PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders.
    Angew. Chem. Int. Ed. AOP (2020)
  11. Nakatsu K, *Hayashi G, *Okamoto A.
    Toolbox for chemically synthesized histone proteins.
    Curr. Opin. Chem. Biol. 58, 10-19 (2020)
    PMID: 32473259
  12. *Ohtake F.
    Mass Spectrometry Technologies for Deciphering the Ubiquitin Code.
    Trends Biochem. Sci. 45, 820-821 (2020)
    PMID: 32423745
  13. Tsuchiya H, Endo A, *Saeki Y.
    Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation.
    Pharmaceuticals (Basel). 13, E128 (2020)
    PMID: 32585960