• 文部科学省
  • JSPS
  • 科研費
  • ユビキチンネオバイオロジー
  • ユビキチンネオバイオロジー
Publications

Publications

Publications

Original Articles

  1. Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, Yamagata A, Goto-Ito S, Mishima M, Ito Y, Oka T, Tanaka K, Fukai S.
    Structural insights into ubiquitin phosphorylation by PINK1.
    Sci. Rep. 8, 10382 (2018)
    PMID: 29991771
  2. Nishiyama Y, Fujii S, Makishima M, Hashimoto Y, Ishikawa M.
    Efficient lead finding, activity enhancement and preliminary selectivity control of nuclear receptor ligands bearing a phenanthridinone skeleton.
    Int. J. Mol. Sci. 19, 2090 (2018)
    PMID: 30021999
  3. Sohtome Y, Shimazu T, Barjau J, Fujishiro S, Akakabe M, Terayama N, Dodo K, Ito A, Yoshida M, Shinkai Y, Sodeoka M.
    Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses.
    Chem. Commun. 54, 9202-9205 (2018)
    PMID: 30063235
  4. Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi Y, Arata M, Ito A, Yoshida M, Nagaoka Y, Sumiyoshi T.
    Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.
    ACS Med. Chem. Lett. 9, 884-888 (2018)
    PMID: 30258535
  5. Shibata N, Shimokawa K, Nagai K, Ohoka N, Hattori T, Miyamoto N, Ujikawa O, Sameshima T, Nara H, Cho N, Naito M.
    Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.
    Sci. Rep. 8, 13549 (2018)
    PMID: 30202081
  6. Furuta H, Yoshihara H, Fukushima T, Yoneyama Y, Ito A, Worrall C, Girnita A, Girnita L, Yoshida M, Asano T, Komada M, Kataoka N, Chida K, Hakuno F, Takahashi SI.
    IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.
    Oncotarget 9, 33871-33883 (2018)
    PMID: 30338032
  7. Azuma Y, Imai H, Kawaguchi Y, Nakase I, Kimura H, Futaki S.
    Modular redesign of a cationic lytic peptide to promote the endosomal escape of biomacromolecules.
    Angew. Chem. Int. Ed. Engl. 57, 12771 (2018)
    PMID: 30101453
  8. Nakamoto Y, Pradipta AR, Mukai H, Zouda M, Watanabe Y, Kurbangalieva A, Ahmadi P, Manabe Y, Fukase K, Tanaka K.
    Expanding the applicability of the metal labeling of biomolecules by the RIKEN click reaction: A case study with Gallium-68 positron emission tomography.
    ChemBioChem. 19, 2055-2060 (2018)
    PMID: 30066425
  9. Wu W, Sahara K, Hirayama S, Zhao X, Watanabe A, Hamazaki J, Yashiroda H, Murata S.
    PAC1‐PAC2 proteasome assembly chaperone retains the core α4–α7 assembly intermediates in the cytoplasm.
    Genes to Cells 23, 839–848 (2018)
    PMID: 30133132
  10. Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL.
    Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.
    PLoS Comput. Biol. 14, e1006532 (2018)
    PMID: 30376562
  11. MacDuff DA, Baldridge MT, Qaqish AM, Nice TJ, Darbandi AD, Hartley VL, Peterson ST, Miner JJ, Iwai K, Virgin HW.
    HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection.
    J. Virol. 92, pii: e01368-18 (2018)
    PMID: 30209176
  12. Tanei T, Pradipta AR, Morimoto K, Fujii M, Arata M, Ito A, Yoshida M, Saigitbatalova E, Kurbangalieva A, Ikeda JI, Morii E, Noguchi S, Tanaka K.
    Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology.
    Adv. Sci. 6, 1801479 (2018)
    PMID: 30693189
  13. Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
    RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
    Cancer Sci. 109, 4003-4014 (2018)
    PMID: 30238564
  14. Sueoka T, Koyama K, Hayashi G, *Okamoto A.
    Chemistry-driven Epigenetic Investigation of Histone and DNA Modifications.
    Chem. Rec. 18, 1727-1744 (2018)
    PMID: 30070422
  15. Kamo N, Hayashi G, Okamoto A.
    Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation.
    Angew. Chem. Int. Ed. 57, 16533-16537 (2018)
    PMID: 30346110
    Highlighted inSYNFACTS 15, 0204 (2018)
  16. Tomita T, Hirayama S, Sakurai Y, Ohte Y, Yoshihara H, Saeki Y, Hamazaki J, Murata S.
    Specific modification of aged proteasomes revealed by tag-exchangeable knock-in mice.
    Mol. Cell Biol. 39, e00426-18 (2018)
    PMID: 30348842
  17. Shioi R, Toyota Y, Noguchi-Yachide T, Ishikawa M. Yamaguchi T, Makishima M, Hashimoto Y, Ohgane K.
    Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands.
    Heterocycles 97, 854-864 (2018)

Review Articles

  1. *Murata S, *Takahama Y, *Kasahara M, *Tanaka K.
    The immunoproteasome and thymoproteasome: functions, evolution and human disease.
    Nat. Immunol. 19, 923–931(2018)
    PMID: 30104634
  2. Koizumi S, Hamazaki J, *Murata S.
    Transcriptional regulation of the 26S proteasome by Nrf1.
    Proc. Jpn. Acad. Ser. B 94, 325–336 (2018)
    PMID: 30305478
  3. Robaa D, Monaldi D, Wössner N, Kudo N, Rumpf T, Schiedel M, Yoshida M, *Jung M.
    Opening the selectivity pocket in the human lysine deacetylase sirtuin2 - new opportunities, new questions.
    Chem. Rec. 18, 1701-1707 (2018)
    PMID: 29931800
  4. Sueoka T, Koyama K, Hayashi G, *Okamoto A.
    Chemistry-driven Epigenetic Investigation of Histone and DNA Modifications.
    Chem. Rec. 18, 1727-1744 (2018)
    PMID: 30070422

Original Articles

  1. Tomaru U, Konno S, Miyajima S, Kimoto R, Onodera M, Kiuchi S, Murata S, Ishizu A, Kasahara M.
    Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells.
    Cell Rep. 26, 639-651. e2 (2019)
    PMID: 3065037
  2. Wu M, Chang Y, Hu H, Mu R, Zhang Y, Qin X, Duan X, Li W, Tu H, Zhang W, Wang G, Han Q, Li A, Zhou T, Iwai K, Zhang X Li H.
    LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores.
    Nat. Commun. 10, 273 (2019)
    PMID: 30655516
  3. Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.
    Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments.
    Nat. Protoc. 14, 415-440 (2019)
    PMID: 30635653
  4. Izuta S, Yamaguchi S,* Kosaka T, *Okamoto A.
    Reversible and Photoresponsive Immobilization of Nonadherent Cells by Spiropyran-Conjugated PEG-Lipids.
    ACS Appl. Bio Mater. 2, 33-38 (2019)
  5. Kawaguchi Y, Ise S, Azuma Y, Takeuchi T, Kawano K, Le TK, Ohkanda J, Futaki S.
    Dipicolylamine/metal complexes that promote direct cell-membrane penetration of octaarginine.
    Bioconjug. Chem. 30, 454-460 (2019)
    PMID: 30428256
  6. Ikeuchi K, Tesina P, Matsuo Y, Sugiyama T, Cheng J, Saeki Y, Tanaka K, Becker T, Beckmann R, Inada T.
    Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.
    EMBO J. 38, e100276 (2019)
    PMID: 30609991
  7. Hitachi K, Nakatani M, Takasaki A, Ouchi Y, Uezumi A, Ageta H, Inagaki H, Kurahashi H, Tsuchida K.
    Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation.
    EMBO Rep. 20, e47468 (2019)
    PMID: 30622218
  8. Ohoka N, Ujikawa O, Shimokawa K, Sameshima T, Shibata N, Hattori T, Nara H, Cho N, Naito M.
    Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER).
    Chem. Pharm. Bull. 67, 203-209 (2019)
    PMID: 30369550
  9. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.
    A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.
    J. Biol. Chem. 294, 2988-2996 (2019)
    PMID: 30610116
  10. Otsubo R, Mimuro H, Ashida H, Hamazaki J, Murata S, Sasakawa C.
    Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation.
    Cell. Microbiol. 21, e12974 (2019)
    PMID: 30414351
  11. Hayashi G, Yanase M, Nakatsuka Y, Okamoto A.
    Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold.
    Biomacromolecules 20, 1246-1253 (2019)
    PMID: 30677290
  12. Ling F, Bradshaw E, Yoshida M.
    Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1.
    Sci. Rep. 9, 5433 (2019)
    PMID: 30931958
  13. Takahashi T, Minami S, Tajima K, Tsuchiya Y, Sakai N, Suga K, Hisanaga S, Obayashi N, Fukuda M, Kawahara H.
    Cytoplasmic control of Rab-family small GTPases through BAG6.
    EMBO Rep. 20, e46794 (2019)
    PMID: 30804014
  14. Ishii N, Walinda E, Iwakawa N, Morimoto D, Iwai K, Sugase K, Shirakawa M.
    NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin.
    Biomol. NMR Assign. 13, 149-153 (2019)
    PMID: 30569274
  15. Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y.
    Rational design of novel amphipathic antimicrobial peptides focused on distribution of cationic amino acid residues.
    MedChemComm 10,896-900 (2019)
    PMID: 31303986
  16. Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H.
    Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
    J. Med. Chem. 62, 3407-3427 (2019)
    PMID: 30883102
  17. Demizu S, Asaka N, Kawahara H, Sasaki E.
    TAS-203, an oral phosphodiesterase 4 inhibitor, exerts anti-inflammatory activities in a rat airway inflammation model.
    Eur. J. Pharmacol. 849, 22-29 (2019)
    PMID: 30716315
  18. Takahashi TS, Sato Y, Yamagata A, Goto-Ito S, Saijo M, Fukai S.
    Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.
    Nucleic Acids Res. 47, 3784-3794 (2019)
    PMID: 30753618
  19. Yanase M, Nakatsu K, Cardos C J, Konda Y, Hayashi G, Okamoto A.
    Cysteinylprolyl Imide (CPI) Peptide: A Highly Reactive and Easily Accessible Crypto-thioester for Chemical Protein Synthesis.
    Chem. Sci. 10, 5967-5975 (2019)
    PMID: 31360403
  20. *Yamaguchi S, Higashi K, Azuma T, *Okamoto A.
    Supramolecular Polymeric Hydrogels for Ultrasound-guided Protein Release.
    Biotechnol. J. 14, 1800530 (2019)
    PMID: 30810275
  21. Shu K, Iwamoto N, Honda K, Kondoh Y, Hirano H, Osada H, Ohno H, Fujii N, Oishi S.
    Development of mirror-image screening systems for XIAP BIR3 domain inhibitors.
    Bioconjug. Chem. 30, 1395-1404 (2019)
    PMID: 30888797
  22. Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H.
    Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation.
    iScience 15, 95-108 (2019)
    PMID: 31055217
  23. Bai M, Zhao X, Sahara K, Ohte Y, Hirano Y, Kaneko T, Yashiroda H, Murata S.
    In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals.
    Biomolecules 9, E213 (2019)
    PMID: 31159305
  24. Qi Y, Zhao X, Chen J, Pradipta AR, Wei J, Ruan H, Zhou L, Hsung R P, Tanaka K.
    In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6.
    Biosci. Biotechnol. Biochem. 83, 1011-1026 (2019)
    PMID: 31074699
  25. Mashita T, Kowada T, Takahashi H, Matsui T, Mizukami S.
    Light-wavelength-based Quantitative Control of Dihydrofolate Reductase Activity Using Photochromic Isostere of Inhibitor.
    ChemBioChem 20, 1382–1386 (2019)
    PMID: 30656808
  26. Sekiguchi Y, Yamada M, Noguchi T, Noomote C, Tsuchida M, Kudoh Y, Hirata Y, Matsuzawa A.
    The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells.
    J. Toxicol. Sci. 44, 435-440 (2019)
    PMID: 31168030
  27. Förster T, Shang E, Shimizu K, Sanada E, Schölermann B, Hübecker M, Hahne G, Pascual Lopez Alberca M, Janning P, Watanabe N, Sievers S, Giordanetto F, Shimizu T, Ziegler S, Osada H Waldmann, H.
    2-Sulfonylpyrimidines target the kinesin HSET via cysteine alkylation.
    Eur. J. Org. Chem. 2019, 5486-5496 (2019)
  28. Koyano F, Yamano K, Kosako H, Tanaka K. 2019, 5486-5496 (2019), Matsuda N.
    Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL.
    J. Biol. Chem. 294, 10300-10314 (2019)
    PMID: 31110043
  29. Arii J, Takeshima K, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
    Roles of the interhexamer Contact Site for Hexagonal Lattice Formation of the Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication.
    J. Virol. 93, e00498-19 (2019)
    PMID: 31043535
  30. Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shin-Ya K, Kimura H, Yoshida M, Murakami S, Kondo Y.
    Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.
    J. Biochem. 166, 41-50 (2019)
    PMID: 30690451
  31. Misawa T, Ohoka N, Oba M, Yamashita H, Tanaka M, Naito M, Demizu Y.
    Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery.
    Chem. Commun. 55, 7792-7795 (2019)
    PMID: 31210205
  32. Usami K, Xiao K, Okamoto A.*
    Efficient Ketose Production by Hydroxyapatite Catalyst in a Continuous Flow Module.
    ACS Sustainable Chem. Eng. 7, 3372-3377 (2019)
  33. Mitsui E, Yoshida S, Shinoda Y, Matsumori Y, Tsujii H, Tsuchida M, Wada S, Hasegawa M, Ito A, Mino K, Onuki T, Yoshida M, Sasaki R, Mizukami T.
    Identification of ryuvidine as a KDM5A inhibitor.
    Sci. Rep. 9, 9952 (2019)
    PMID: 31289306
  34. Hayashishita M, Kawahara H, Yokota N.
    BAG6 deficiency induces mis-distribution of mitochondrial clusters under depolarization.
    FEBS Open Bio. 9, 1281-1291 (2019)
    PMID: 31125507
  35. Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, Iwasaki S.
    Genome-wide survey of ribosome collision.
    bioRxiv
  36. Takase S, Kurokawa R, Kondoh Y, Honda K, Suzuki T, Kawahara T, Ikeda H, Dohmae N, Osada H, Shin-Ya K, Kushiro T, Yoshida M, Matsumoto K.
    Mechanism of action of prethioviridamide, an anticancer ribosomally synthesized and post-translationally modified peptide with a polythioamide structure.
    ACS Chem. Biol. 14, 1819-1828 (2019)
    PMID: 31365229
  37. Arata Y, Watanabe A, Motosugi R, Iemura S, Natsume T, Mukai K, Taguchi T, Hirayama S, Hamazaki J, Murata S.
    FAM48A mediates compensatory autophagy induced by proteasome impairment.
    Genes to Cells 24, 559–568 (2019)
    PMID: 31210371
  38. Sasaki K, Himeno A, Nakagawa T, Sasaki Y, Kiyonari H, Iwai, K.
    Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
    Nat. Commun. 10, 3878 (2019)
    PMID: 31462647
  39. Yoshida K, Kondoh Y, Iwahashi F, Nakano T, Honda K, Nagano E, Osada H.
    Abscisic acid derivatives with different alkyl chain lengths activate distinct abscisic acid receptor subfamilies.
    ACS Chem. Biol. 14, 1964-1971 (2019)
    PMID: 31497942
  40. Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T.
    The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.
    J. Biol. Chem. 294, 14135–14148 (2019)
    PMID: 31366726
  41. Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S.
    A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.
    J. Biol. Chem. 294, 14562-14573 (2019)
    PMID: 31371451
  42. Masuda Y, Saeki Y, Arai N, Kawai H, Kukimoto I, Tanaka K, Masutani C.
    Stepwise multipolyubiquitantion of p53 by the E6AP-E6 ubiquitin ligase complex.
    J. Biol. Chem. 294, 14860-14875 (2019)
    PMID: 31492752
  43. Takeshima K, Arii J (contributed equally), Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
    Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication.
    J. Virol. 93, e01290-19 (2019)
    PMID: 31391274
  44. Kamo N, Hayashi G, Okamoto A.
    Chemical Synthesis of Cys-Containing Protein via Chemoselective Deprotection with Different Palladium Complexes.
    Org. Lett. 21, 8378-8382 (2019)
    PMID: 31560553
  45. Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H.
    p63 is a cereblon substrate involved in thalidomide teratogenicity.
    Nat. Chem. Biol. 15, 1077-1084 (2019)
    PMID: 31591562
  46. Yokosawa T, Yamada M, Noguchi T, Suzuki S, Hirata Y, Matsuzawa A.
    Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation.
    J. Antibiotics 72, 848-852 (2019)
    PMID: 31371783
  47. Jarzebska N A, Yamaguchi S,* Izuta S, Kosaka T, Yamahira S, Nagamune T, Okamoto A.*
    Photo-responsive materials with strong cell trapping ability for light-guided manipulation of nonadherent cells.
    Biomater. Sci. 7, 4514-4518 (2019)
    PMID: 31602442
  48. Chulakova D R, Pradipta AR, Lodochnikova OA, Kuznetsov DR, Bulygina KS, Smirnov IS, Usachev KS, Latypova LZ, Kurbangalieva AR, Tanaka K.
    Facile access to optically active 2,6-dialkyl-1,5-diazacyclooctanes.
    Chem. Asian J. 14, 4048-4054 (2019)
    PMID: 31381243
  49. Goto C, Hirano M, Hayashi K, Kikuchi Y, Hara-Kudo Y, Misawa T, Demizu Y.
    Development of amphipathic antimicrobial peptide foldamers based on Magainin 2 sequence.
    ChemMedChem 14,1911-1916 (2019)
    PMID: 31667994
  50. Kamada Y, Fukuda R, Okiyoneda T.
    ELISA Based Protein Ubiquitylation Measurement.
    Bio-protocol 9, e3430 (2019)
  51. Yang N, Liu S, Qin T, Liu X, Watanabe N, Mayo KH, Li J, Li X.
    SUMO3 Modification by PIAS1 Modulates Androgen Receptor Cellular Distribution and Stability.
    Cell Commun. Signal. 17, 153 (2019)
    PMID: 31752909
  52. Nomura S, Takahashi H, Suzuki J, Kuwahara M, Yamashita M, Sawasaki T.
    Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro.
    Sci. Rep. 9,17335 (2019)
    PMID: 31758034
  53. Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin AC, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y.
    Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.
    Cell Rep. 29, 2901-2916.e6 (2019)
    PMID: 31775054
  54. Abe T, Shizu R, Sasaki T, Shimizu Y, Hosaka T, Kodama S, Matsuzawa A, Yoshinari K.
    Functional interaction between PXR and YAP in xenobiotic-dependent liver hypertrophy and drug metabolism.
    J. Pharmacol. Exp. Ther. 371, 590-601(2019)
    PMID: 31533970
  55. Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N.
    Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.
    EMBO Rep. 20, e47728 (2019)
    PMID: 31602805
  56. Ohoka N, Tsuji G, Shoda T, Fujisato T, Kurihara M, Demizu Y, Naito M.
    Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins.
    ACS Chem. Biol. 14, 2822-2832 (2019)
    PMID: 31580635
  57. Kwong MMY, Lee JW, Samian MR, Watanabe N, Osada H, Ong EBB.
    Comparison of microplate-and bottle-based methods to age yeast for chronological life span assays.
    J. Microbiol. Methods. 167 105743 (2019)
    PMID: 31629019
  58. Arata Y, Watanabe A, Motosugi R, Murakami R, Goto T, Hori S, Hirayama S, Hamazaki J, Murata S.
    Defective induction of the proteasome associated with T‐cell receptor signaling underlies T‐cell senescence.
    Genes to Cells 24, 801–813 (2019)
    PMID: 31621149
  59. Sato Y, Tsuchiya H, Yamagata A, Okatsu K, Tanaka, K, Saeki Y, Fukai S.
    Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4.
    Nat. Commun. 10, 5708 (2019)
    PMID: 31836717
  60. Imoto T, Muramatsu M, Miyasaka H, Mizukami S, Kikuchi K.
    Improvement in Photostability of Fluorescein by Lanthanide Ions based on Energy Transfer-Based Triplet State Quenching
    Chem. Lett. 48, 1181–1184 (2019)

Review Articles

  1. *Yoshida M.
    Recent advances in target identification of bioactive natural products.
    Biosci. Biotechnol. Biochem. 83, 1-9 (2019)
    PMID: 30343630
  2. Ohtake F, Tsuchiya H, Tanaka K, *Saeki Y.
    Methods to measure ubiquitin chain length and linkage.
    Methods Enzymol. 618, 105-133 (2019)
    PMID: 30850048
  3. Yoshida Y, Saeki Y, Tsuchiya H, *Tanaka K.
    TR-TUBE system: Method for detecting ubiquitination activity and identifying ubiquitinated substrates
    Methods Enzymol. 618, 135-147 (2019)
    PMID: 30850049  
  4. Shibata N, Ohoka N, Hattori T, *Naito M.
    Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein.
    Chem. Pharm. Bull. 67, 165-172 (2019)
    PMID: 30827996
  5. *Naito M, Ohoka N, Shibata N.
    SNIPERs-Hijacking IAP activity to induce protein degradation.
    Drug Discov. Today: Technol. 31, 35-42 (2019)
    PMID: 31200857
  6. Motosugi R, *Murata S.
    Dynamic Regulation of Proteasome Expression.
    Front. Mol. Biosci. 6, 30 (2019)
    PMID: 31119134
  7. *Inada T.
    The mechanism for recycling tRNAs on stalled ribosomes.
    Nat. Struc. Mol. Biol. 26, 340-342 (2019)
    PMID: 31011210
  8. Wei W, Rasul A, Sadiqa A, Sarfraz I, Hussain G, Nageen B, Liu X, Watanabe N, Selamoglu Z, Ali M, *Li X, *Li J.
    Curcumol: From Plant Roots to Cancer Roots.
    Int. J. Biol. Sci. 15, 1600-1609 (2019)
    PMID: 31360103
  9. Asatsuma-Okumura T, Ito T (co-1st author), *Handa H.
    Molecular mechanisms of cereblon-based drugs.
    Pharmacol. Ther. 202, 132-139. (2019)
    PMID: 31202702
  10. *Yashiroda Y, Yoshida M.
    Intraspecies cell-cell communication in yeast.
    FEMS Yeast Res. 19, pii: foz071 (2019)
    PMID: 31688924
  11. *Naito M, Ohoka N, Shibata N, Tsukumo Y.
    Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs.
    Front. Chem. 7, 849 (2019)
    PMID: 31921772
  12. *Inada T.
    The proteasome's balancing act.
    Nat. Plants 5,1203-1204 (2019)
    PMID: 31740771
  13. Ageta H, *Tsuchida K.
    Post-translational modification and protein sorting to small extracellular vesicles including exosomes by ubiquitin and UBLs.
    Cell. Mol. Life Sci. 76,4829-4848 (2019)
    PMID: 31363817

Original Articles

  1. Yamashita H, Tomoshige S, Nomura S, Ohgane K, Hashimoto Y, Ishikawa M.
    Application of Protein Knockdown Strategy Targeting β-Sheet Structure to Multiple Disease-associated Polyglutamine Proteins.
    Bioorg. Med. Chem. 28, 115175 (2020)
    PMID: 31767406
  2. Lodochnikova OA, Chulakova DR, Gerasimova DP, Litvinov IA, Pradipta AR, Tanaka K, Kurbangalieva AR.
    Stereochemical features of the crystallization of eight-membered 1,5-diazaheterocycles with chiral aminoindanol fragments at nitrogen atoms.
    J. Struct. Chem. 61, 119-125 (2020)
  3. Mimami S, Yokota N, Kawahara H.
    BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
    Biol. Open 9, bio047324 (2020)
    PMID: 31911483
  4. Mishima Y, Brueckner L, Takahashi S, Kawakami T, Otani J, Shinohara A, Takeshita K, Garvilles RG, Watanabe M, Sakai N, Takeshima H, Nachtegael C, Nishiyama A, Nakanishi M, Arita K, Nakashima K, Hojo H, Suetake I.
    Enhanced processivity of Dnmt1 by monoubiquitinated histone H3.
    Genes Cells 25, 22-32 (2020)
    PMID: 31680384
  5. Yamada M, Suzuki M, Noguchi T, Yokozawa T, Sekiguchi Y, Mutoh N, Toyama T, Hirata Y, Hwang GW, Matsuzawa A.
    The antibiotic cefotaxime works as both an activator of Nrf2 and an inducer of HSP70 in mammalian cells.
    BPB Rep. 3, 16-21 (2020)
  6. Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y.
    Stress- and ubiquitylation-dependent phase separation of the proteasome.
    Nature 578, 296-300 (2020)
    PMID: 32025036
    Highlighted in Cell Res
    EurekAlert!
    Faculty Opinions
  7. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.
    Measurement of ATPase activity of valosin-containing protein/p97.
    Bio-protocol 10, e3516 (2020)
  8. Suvarna K, Honda K, Muroi M, Kondoh Y, Watanabe N, Osada H.
    Identification of target protein for bio-active small molecule using photo-cross linked beads and MALDI-TOF mass spectrometry.
    Bio-protocol 10, e3517 (2020)
  9. Hirata Y, Inoue A, Suzuki S, Takahashi M, Matsui R, Kono N, Noguchi T, Matsuzawa A.
    trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop.
    Sci. Rep. 10, 2743 (2020)
    PMID: 32066809
  10. Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
    Targeted protein degradation by chimeric compounds using hydrophobic E3 ligands and adamantane moiety.
    Pharmaceuticals 13, E34 (2020)
    PMID: 32106507
  11. Hashimoto S, Sugiyama T, Yamazaki R, Nobuta R,*Inada T.
    Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells.
    Sci. Rep. 10, 3422(2020)
    PMID: 32099016
  12. Takahashi H, Ranjan A, Chen S, Suzuki H, Shibata M, Hirose T, Hirose H, Sasaki K, Abe R, Chen K, He Y, Zhang Y, Takigawa I, Tsukiyama T, Watanabe M, Fujii S, Iida M, Yamamoto J, Yamaguchi Y, Suzuki Y, Matsumoto M, Nakayama KI, Washburn M, Saraf A, Florens L, Sato S, Tomomori-Sato C, Conaway RC, Conaway JW, *Hatakeyama S.
    The role of Mediator and Little Elongation Complex in transcription termination.
    Nature Commun. 11, 1063 (2020)
    PMID: 32102997
  13. Brazee PL, Morales-Nebreda L, Magnani ND, Garcia JG, Misharin AV, Ridge KM, Budinger GRS, Iwai K, Dada LA, Sznajder, JI.
    Linear ubiquitin assembly complex regulates lung epithelial-driven responses during influenza infection.
    J. Clin. Invest. 130, 1301-1314 (2020)
    PMID: 31714898
  14. Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, Tamura N, Hatanaka A, Hirose S, Katayama H, Tani M, Kubo Y, Hamazaki J, Hamakubo T, Watanabe A, Murata S, Kobayashi A.
    NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.
    Mol. Cell. Biol. 40,e597-19 (2020)
    PMID: 32123008
  15. Tateno S, Iida M, Fujii S, Suwa T, Katayama M, Tokuyama H, Yamamoto J, Ito T, Sakamoto S, Handa H, Yamaguchi Y.
    Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide.
    Sci. Rep. 10,4012 (2020)
    PMID: 32132601
  16. Nishiyama A, Mulholland C, Bultmann S, Kori A, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H, Nakanishi M.
    Two distinct modes of DNMT1 recruitment ensure the stable maintenance DNA methylation.
    Nat. Commun. 11, 1222 (2020)
    PMID: 32144273
    Faculty Opinions
  17. Shibata N, Ohoka N, Tsuji G, Demizu Y, Akiyama T, Naito M.
    Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.
    Oncogene 39,3867-3878 (2020)
    PMID: 32203161
  18. Arafiles JVV, Hirose H, Akishiba M, Tsuji S, Imanishi M, Futaki S.
    Stimulating macropinocytosis for intracellular nucleic acid and protein delivery: a combined strategy with membrane-lytic peptides to facilitate endosomal escape.
    Bioconjug. Chem. 31, 547-553 (2020)
    PMID: 32017537
  19. Matsuo Y, Tesina P, Nakajima S, Mizuno M, Endo A, Buschauer R, Cheng J, Shounai O, Ikeuchi K, Iwasaki S, Saeki Y, Becker T, Beckmann R, Inada T.
    RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
    Nat. Stuct. Mol. Biol. 27, 323-332 (2020)
    PMID: 32203490
  20. Takaoka Y, Miyagawa S, Nakamura A, Egoshi S, Tsukiji S, Ueda M.
    Hoechst-tagged Fluorescein Diacetate for the Fluorescence Imaging-based Assessment of Stomatal Dynamics in Arabidopsis thaliana.
    Sci. Rep. 10, 5333 (2020)
    PMID: 32210301
  21. Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunaga F, Takahashi H, Sawasaki T.
    Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
    Biochem. Biophys. Res. Commun. 524, 1-7 (2020)
    PMID: 31898971
  22. Naito S, Fukushima T, Endo A, Denda K, Komada M.
    Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.
    FEBS Lett. 594,1778-1786 (2020)
    PMID: 32162334
  23. Tsuchida M, Yokozawa T, Noguchi T, Shimada T, Yamada M, Sekiguchi Y, Hirata Y, Matsuzawa A.
    Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin.
    J. Toxicol. Sci. 45, 219-226 (2020)
    PMID: 32238696
  24. Morihiro K, Okamoto A.
    A highly constrained nucleic acid analog based on α-L-threosamine.
    Nucleosides Nucleotides Nucleic Acids 39, 270-279 (2020)
    PMID: 31530088
  25. Luong NC, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, Noguchi T, Matsuzawa A, Kumagai Y.
    Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B.
    J. Toxicol. Sci. 45, 349-363 (2020)
    PMID: 32493877
  26. Wang L, Liu S, Xu J, Watanabe N, Di J, Wei W, Mayo KH, Li J, Li X.
    A traditional Chinese Medicine, YXQN, Reduces Amyloid-induced Cytotoxicity by Inhibiting Aβ42 Aggregation and Fibril Formation.
    Curr. Pharm. Des. 26, 780-789 (2020)
    PMID: 32031066
  27. Chen J, Morihiro K, Fukui D, Guo L, Okamoto A.
    Live-Cell Sensing of Telomerase Activity Using Hybridization-Sensitive Fluorescent Oligonucleotide Probes.
    ChemBioChem 21, 1022-1027 (2020)
    PMID: 31840916
  28. Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
    Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
    Commun. Biol. 3, 163 (2020)
    PMID: 32246052
  29. Pradipta AR, Tanei T, Morimoto K, Shimazu K, Noguchi S, Tanaka K.
    Emerging technologies for real-time intraoperative margin assessment in future breast-conserving surgery.
    Adv. Sci. 7, 1901519 (2020)
    PMID: 32382473
  30. Buschauer R, Matsuo Y (co-1st author), Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Gilmozzi A, Berninghausen O, Becker T, Coller J, Inada T, Beckmann R.
    The Ccr4-Not complex monitors the translating ribosome for codon optimality.
    Science 368, 6448 (2020)
    PMID: 32299921
  31. Sugawara E, Kato M, Kudo Y, Lee W, Hisada R, Fujieda Y, Oku K, Bohgaki T, Amengual O, Yasuda S, Onodera T, Hatakeyama S, Atsumi T.
    Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts,
    Autophagy 16, 946-955 (2020)
    PMID: 31486697
  32. Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, Iwasaki S.
    Genome-wide survey of ribosome collision.
    Cell Rep. 31,107610 (2020)
    PMID: 32375038
  33. Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O.
    The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis.
    J. Am. Acad. Dermatol. 84,1103-1105 (2020)
    PMID: 32439465
  34. Sako K, Futamura Y, Shimizu T, Matsui A, Hirano H, Kondoh Y, Muroi M, Aono H, Tanaka M, Honda K, Shimizu K, Kawatani M, Nakano T, Osada H, Noguchi K, Seki M.
    Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.
    Sci. Rep. 10, 8691 (2020)
    PMID: 32457324
  35. Tamemoto N, Akishiba M, Sakamoto K, Kawano K, Noguchi H, Futaki S.
    Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules.
    Mol. Pharm. 17, 2175-2185 (2020)
    PMID: 32352304
  36. Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, Sawasaki T.
    A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors.
    Biomedicines 8, 152 (2020)
    PMID: 32512835
  37. Sakamoto K, Akishiba M, Iwata T, Murata K, Mizuno S, Kawano K, Imanishi M, Sugiyama F, Futaki S.
    Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules.
    Angew. Chem. Int. Ed. Engl. 59, 19990-19998 (2020)
    PMID: 32557993
  38. Nakatsu K, Yanase M, Hayashi G, Okamoto A.
    Fmoc-Compatible and C-terminal-Sequence-Independent Peptide Alkyl Thioester Formation Using Cysteinylprolyl Imide.
    Org. Lett. 22, 4670-4674 (2020)
    PMID: 32484687
  39. Fuseya Y, Fujita H, Kim M, Ohtake F, Nishide A, Sasaki K, Saeki Y, Tanaka K, Takahashi R, Iwai K.
    The HOIL-1L ligase modulates immune signaling and cell death via mono-ubiquitination of LUBAC.
    Nat. Cell Biol. 22, 663-673 (2020)
    PMID: 32393887
  40. Jo T, Nishikori M, Kogure Y, Arima H, Sasaki K, Sasaki Y, Nakagawa T, Iwai F, Momose S, Shiraishi A, Kiyonari H, Kagaya N, Onuki T, Shin-Ya K, Yoshida M, Kataoka K, Ogawa S, Iwai K, Takaori-Kondo A.
    LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells.
    Blood 136, 684–697 (2020)
    PMID: 32325488
  41. Kori S, Jimenji T, Ekimoto T, Sato M, Kusano F, Oda T, Unoki M, Ikeguchi M, Arita K.
    Serine 298 phosphorylation in linker 2 of UHRF1 regulates ligand-binding property of its tandem Tudor domain.
    J. Mol. Biol. 432, 4064-4078 (2020)
    PMID: 32428527
  42. Sugisawa E, Takayama Y, Takemura N, Kondo T, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, *Maruyama K.
    RNA sensing by gut Piezo1 is essential for systematic serotonin synthesis.
    Cell 182, 609-624 (2020)
    PMID: 32640190
  43. Pradipta A R, Chang T C, Tanaka K.
    Enantioselective synthesis of cyclic and linear diamines by iminocycloaddition.
    Chirality 32, 1160-1168 (2020)
    PMID: 32621328
  44. Yamaguchi S, Takagi R, Hosogane T, Ohashi Y, Sakai Y, Sakakihara S, Iino R, Tabata K, Noji H, Okamoto A.
    Single cell array enclosed with a photodegradable hydrogel in microwells for image-based cell classification and selective photorelease of cells.
    ACS Appl. Bio Mater. 3,9, 5887–5895 (2020)
  45. Matsuura Y, Noguchi A, Yokota N, Kawahara H.
    Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster.
    J. Biochem. 168,477-489 (2020)
    PMID: 32687160
  46. Suzuki G, Imura S, Hosokawa M, Katsumata R, Nonaka T, Hisanaga SI, Saeki Y, Hasegawa M.
    α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome.
    eLife 9, e56825 (2020)
    PMID: 32697196
  47. Hashimoto E, Okuno S, Hirayama S, Arata Y, Goto T, Kosako H, Hamazaki J, Murata S.
    Enhanced O-GlcNAcylation mediates cytoprotection under proteasome impairment by promoting proteasome turnover in cancer cells.
    iScience 23,101299 (2020)
    PMID: 32634741
  48. Yokoo H, Ohoka N, Naito M, Demizu Y.
    Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.
    Bioorg. Med. Chem. 28,115595 (2020)
    PMID: 32631565
  49. Wang L, Liu S, Xu J, Watanabe N, Mayo KH, Li J, Li X.
    Emodin inhibits aggregation of amyloid-β peptide 1-42 and improves cognitive deficits in Alzheimer's disease transgenic mice.
    J. Neurochem. AOP (2020)
    PMID: 32799401
  50. Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M.
    Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.
    ACS Chem. Biol. 15, 2195-2204 (2020)
    PMID: 32584541
  51. Kawamura T, Futamura Y, Shang E, Muroi M, Janning P, Ueno M, Wilke J, Takeda S, Kondoh Y, Ziegler S, Watanabe N, Waldmann H, Osada H.
    Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics.
    Biosci. Biotech. Biochem. 84, 2484-2490 (2020)
    PMID: 32867616
  52. Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, Matsuda N.
    Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy.
    J. Cell Biol. 219, e201912144 (2020)
    PMID: 32556086
  53. Kondo T, Iwatani Y, Matsuoka K, Fujino T, Umemoto S, Yokomaku Y, Ishizaki K, Kito S, Sezaki T, Hayashi G, Murakami H.
    Antibody-like proteins that capture and neutralize SARS-CoV-2.
    Sci. Adv. 6, eabd3916 (2020)
    PMID: 32948512
  54. Hirata Y, Nada Y, Yamada Y, Toyama T, Fukunaga K, Hwang GW, Noguchi T, *Matsuzawa A.
    Elaidic acid potentiates extracellular ATP-induced apoptosis via the P2X7-ROS-ASK1-p38 axis in microglial cell lines.
    Biol. Pharm. Bull. 43, 1562-1569 (2020)
    PMID: 32999166
  55. Sophonnithiprasert T, Aruksakunwong O, Tashiro E, Kondoh Y, Muroi M, Osada H, Imoto M, Watanapokasin R.
    Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress.
    Heliyon 6, e05200 (2020)
    PMID: 33102840
  56. Yamamoto J, Suwa T, Murase Y, Tateno S, Mizutome H, Asatsuma-Okumura T, Shimizu N, Kishi T, Momose S, Kizaki M, Ito T, Yamaguchi Y, Handa H.
    ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells.
    Nat. Chem. Biol. 16, 1208-1217 (2020)
    PMID: 32958952
  57. Kowada T, Watanabe T, Amagai Y, Liu R, Yamada M,Takahashi H, Matsui T, Inaba K, Mizukami S.
    Quantitative imaging of labile Zn2+ in the Golgi apparatus using a localizable small-molecule fluorescent probe
    Cell Chem. Biol. 27, 1521–1531 (2020)
    PMID: 32997976
  58. Radwan MO, Ciftci HI, Ali TFS, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Fujita M, Otsuka M.
    Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
    Bioorg. Med. Chem. Lett. 30,127458 (2020)
    PMID: 32755678
  59. Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.
    A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.
    Biosci. Biotechnol. Biochem. 84,2113-2120 (2020)
    PMID: 32640867
  60. Ogata M, Hayashi G, Ichiu A, Okamoto A.
    L-DNA-tagged fluorescence in situ hybridization for highly sensitive imaging of RNAs in single cells.
    Org. Biomol. Chem. 18,8084-8088 (2020)
    PMID: 33001106
  61. Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S.
    A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
    Commun. Biol. 3,592 (2020)
    PMID: 33082525
  62. Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.
    Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.
    Environ. Pollut. 266, 115179 (2020)
    PMID: 32717636
  63. Pan Y, Zhao Y, Kuang R, Liu H, Sun D, Mao T, Jiang K, Yang X, Watanabe N, Mayo KH, Lin Q, Li J.
    Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion.
    Mater. Sci. Eng., C 116, 111158 (2020)
    PMID: 32806272
  64. Smirnov I, Sibgatullina R, Urano S, Tahara T, Ahmadi P, Watanabe Y, Pradipta AR, Kurbangalieva A, *Tanaka K.
    A Strategy for Tumor Targeting by Higher-Order Glycan Pattern Recognition: Synthesis and In Vitro and In Vivo Properties of Glycoalbumins Conjugated with Four Different N-Glycan Molecules.
    Small 16, 2004831 (2020)
    PMID: 33079456
  65. Inoue S, Kaiserli E, Zhao X, Waksman T, Takemiya A, Okumura M, Takahashi H, Seki S, Shinozaki K, Endo Y, Sawasaki T, Kinoshita T, Zhang X, Christie J, Shimazaki K.
    CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.
    Plant J. 104, 679-692 (2020)
    PMID: 32780529
  66. Arii J, Maeda F, Maruzuru Y, Koyanagi N, Kato A, Mori Y, Kawaguchi Y.
    ESCRT-III controls nuclear envelope deformation induced by progerin.
    Sci. Rep. 10, 18877 (2020)
    PMID: 33139753
  67. Kudo T, Tominami K, Izumi S, Hayashi Y, Noguchi T, Matsuzawa A, Hong G, Nakai J.
    Characterization of PC12 cell subclones with different sensitivities to programmedthermal stimulation.
    Int. J. Mol. Sci., 21, 8356 (2020)
    PMID: 33171774
  68. Matsuki Y, Matsuo Y, Nakano Y, Iwasaki S, Yoko H, Udagawa T, Li S, Saeki Y, Yoshihisa T, Tanaka K, Ingolia N, *Inada T.
    Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome.
    Sci. Rep. 10, 19669 (2020)
  69. Hao F, Murphy KJ, Kujirai T, Kamo N, Kato J, Koyama M, Okamoto A, Hayashi G, Kurumizaka H, *Hayes JJ.
    Acetylation-Modulated Communication between the H3 N-Terminal Tail Domain and the Intrinsically Disordered H1 C-Terminal Domain.
    Nucleic Acids Res. 48, 11510–11520 (2020)
    PMID: 33125082
  70. Oikawa D, Hatanaka N, Suzuki T, *Tokunaga F.
    Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-mediated NF-kB Activation Pathway.
    Front Immunol. 11, 601926 (2020)
    PMID: 33329596
  71. Arii J, Fukui A, Shimanaka Y, Kono N, Arai H, Maruzuru Y, Koyanagi N, Kato A, Mori Y, Y Kawaguchi.
    Role of phosphatidyl-ethanolamine biosynthesis in herpes simplex virus 1 infected cells on progeny virus morphogenesis in the cytoplasm and on viral pathogenicity in vivo.
    J. Virol. 94, e01572-20 (2020)
    PMID: 32999028
  72. Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück IM, Trummer C, Qin W, Bartoschek MD, Traube FR, Parsa E, Ugur E, Modic M, Acharya A, Stolz P, Ziegenhain C, Wierer M, Enard W, Carell T, Lamb DC, Takeda H, Nakanishi M, Bultmann S, *Leonhardt H.
    Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals.
    Nat. Commun. 11, 5972 (2020)
    PMID: 33235224
  73. Suzuki M, Asai Y, Kagi T, Noguchi T, Yamada M, Hirata Y, *Matsuzawa A.
    TAK1 Mediates ROS Generation Triggered by the Specific Cephalosporins through Noncanonical Mechanisms.
    Int. J. Mol. Sci., 21, 9497 (2020)
    PMID: 33327477
  74. Muguruma K, Pradipta AR, Ode Y, Terashima K, Michiba H, Fujii M, *Tanaka K.
    Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry.
    Bioorg. Med. Chem. 28, 115831 (2020)
    PMID: 33199202
  75. Hirano M, Saito C, Goto C, Yokoo H, Kawano R, *Misawa T, *Demizu Y.
    Rational design of helix-stabilized antimicrobial peptide foldamers containing α,α-disubstituted amino acids or side-chain stapling.
    ChemPlusChem 85,2731-2736 (2020)
    PMID: 33369262

Review Articles

  1. *Itoh Y.
    Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches.
    Chem. Pharm. Bull. 68, 34-45 (2020)
    PMID: 31902900
  2. Takaoka Y, Hayashi K, Suzuki K, Azizah IN, * Ueda M.
    A Fluorescence Anisotropy-Based Comprehensive Method for the In Vitro Screening of COI1-JAZs Agonists and Antagonists.
    Methods Mol. Biol. 2085, 145-160 (2020)
    PMID: 31734923
  3. Ito T, *Handa H.
    Molecular mechanisms of thalidomide and its derivatives.
    Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 96,189-203 (2020)
    PMID: 32522938
  4. *Inada T.
    Quality controls induced by aberrant translation.
    Nucleic Acids Res. 48, 1084-1096 (2020)
    PMID: 31950154
  5. *Matsuda N, Yamano K.
    Two sides of a coin: physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin.
    Neurosci. Res. 159. 16-24 (2020)
    PMID: 32201358
  6. Fukuda R, *Okiyoneda T.
    Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitylation as a Novel Pharmaceutical Target for Cystic Fibrosis.
    Pharmaceuticals(Basel) 13,75 (2020)
    PMID: 32331485
  7. *Ishikawa M, Tomoshige S, Demizu Y, Naito M.
    Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs.
    Pharmaceuticals 13,74 (2020)
    PMID: 32326273
  8. Asatsuma-Okumura T, *Ito T, Handa H.
    Molecular Mechanisms of the Teratogenic Effects of Thalidomide.
    Pharmaceuticals 96,189-203 (2020)
    PMID: 32414180
  9. Oikawa D, Sato Y, Ito H, *Tokunaga F.
    Linear ubiquitin code: Its writer, erasers, decoders, inhibitors, and implications in disorders.
    Int. J. Mol. Sci. 21,E3381, 2020.
    PMID: 32403254
  10. Tomoshige S, *Ishikawa M.
    PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders.
    Angew. Chem. Int. Ed. 3346-3354 (2020)
  11. Nakatsu K, *Hayashi G, *Okamoto A.
    Toolbox for chemically synthesized histone proteins.
    Curr. Opin. Chem. Biol. 58, 10-19 (2020)
    PMID: 32473259
  12. *Ohtake F.
    Mass Spectrometry Technologies for Deciphering the Ubiquitin Code.
    Trends Biochem. Sci. 45, 820-821 (2020)
    PMID: 32423745
  13. Tsuchiya H, Endo A, *Saeki Y.
    Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation.
    Pharmaceuticals (Basel). 13, E128 (2020)
    PMID: 32585960
  14. Futaki S, Arafiles JVV, Hirose H.
    Peptide-assisted intracellular delivery of biomacromolecules.
    Chem. Lett. 49, 1088–1094 (2020)
  15. Yokoo H, *Misawa T, *Demizu Y.
    De novo design of cell-penetrating foldamers.
    Chem. Rec. 20,912-921 (2020)
    PMID: 32463155
  16. *Yamano K, Youle RJ.
    Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy.
    Autophagy 16, 2105-2107 (2020)
    PMID: 32892694
  17. *Watanabe N, Osada H.
    Small molecule inhibitors of E3 ubiquitin ligases.
    Drug Discovery Series No. 78
    Protein-Protein Interaction Regulators (Roy, S. and Fu, H. eds.) Royal Society of Chemistry pp.109-123 (2020)

Original Articles

  1. Suzuki K, *Takaoka Y, Ueda M.
    Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor.
    RSC. Chem. Biol. 2, 499-502 (2021)
    PMID: 34458795
  2. Udagawa T, Seki M, Okuyama T, Adachi S, Natsume T, Noguchi T, Matsuzawa A, *Inada T.
    Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival.
    Cell Rep. 34, 108599 (2021)
    PMID: 33406423
  3. Noguchi T, Sekiguchi Y, Kudoh Y, Naganuma R, Kagi T, Nishidate A, Maeda K, Ishi C, Toyama T, Hirata Y, Hwang GW, *Matsuzawa A.
    Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms.
    Cell Death Dis. 12, 49 (2021)
    PMID: 33414419
  4. *Watanabe M, *Arii J, Takeshima K, Fukui A, Shimojima M, Kozuka-Hata H, Oyama M, Minamitani T, Yasui T, Kubota Y, Takekawa M, Kosugi I, Maruzuru Y, Koyanagi N, Kato A, Mori Y, Kawaguchi Y.
    Prohibitin-1 contributes to the cell-to-cell transmission of herpes simplex virus 1 via the MAPK/ERK signaling pathway.
    J. Virol. 95, e01413-20 (* contributed equally) (2021)
    PMID: 33177205
  5. Yokoo H,# Shibata N,# Naganuma M, Murakami Y, Ito T, *Aritake K, *Naito M, *Demizu Y.
    Development of hematopoietic prostaglandin D synthase-degradation inducer.
    ACS Med. Chem. Lett. 12,236-241 (2021)
    PMID: 33603969
  6. Hirano M, Saito C, Yokoo H, Goto C, Kawano R, *Misawa T, *Demizu Y.
    Structure-activity relationship analysis of Mag2-based peptide foldamers.
    Molecules 26,444 (2021)
    PMID: 33466998
  7. Nakabayashi O, Takahashi H, Moriwaki K, Komazawa-Sakon S, Ohtake-F, Murai Y, Koyahara Y, Saeki Y, Yoshida Y, Yamazaki S, Tokunaga F, Sawasaki T, *Nakano H.
    MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL.
    Commun. Biol. 4, 80 (2021)
    PMID: 33469115
  8. Iida T, *Itoh Y, Takahashi Y, Yamashita Y, Kurohara T, Miyake Y, Oba M, Suzuki T.
    Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders.
    ChemMedChem 16, 1609-1618 (2021)
    PMID: 33470543
  9. Wilke J, Kawamura T, Xu H, Brause A, Friese A, Metz M, Schepmann D, Wünsch B, Artacho-Cordón A, Nieto FR, Watanabe N, Osada H, Ziegler S, *Waldmann H.
    Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.
    Cell Chem. Biol. 28, 1-7 (2021)
    PMID: 33567254
  10. Kojima W, *Yamano K, Kosako H, Imai K, Kikuchi R, Tanaka K, Matsuda N.
    Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy.
    Autophagy 17, 2011-2036 (2021)
    PMID: 33499712
  11. Soma-Kaiho A, Akizuki Y, Igarashi K, Endo A, Kawase Y, Shoda T, Demizu Y, Naito M, Saeki Y, Tanaka K, *Ohtake F.
    TRIP12 enhances small molecule-induced degradation of BRD4 through K29/K48 branched ubiquitin chains.
    Mol. Cell. 81, 1411-1424.e7 (2021)
    PMID: 33567268
  12. Takehara Y, Yashiroda H, Matsuo Y, Zhao X, Kamigaki A, Matsuzaki T, Kosako H, Inada T, *Murata S.
    The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation.
    iScience 24, 102145 (2021)
    PMID: 33665564
  13. Dat NQ, Thuy LTT, Hieu VN, Hai H, Hoang DV, Hai NTT, Thuy TTV, Komiya T, Rombouts K, Phuong DM, Hanh NV, Hoang TH, Sato-Matsubara M, Oikawa D, Yoishizato K, Tokunaga F, Pinzani M, *Kawada M.
    His-Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
    Hepatology. 73, 2527-2545 (2021)
    PMID: 33576020
  14. *Kitanosono T, Hisada T, Yamashita Y, Kobayashi S.
    Hydrogen-Bonding-Assisted Cationic Aqua Palladium(II) Complex Enables Highly Efficient Asymmetric Reactions in Water.
    Angew. Chem. Int. Ed.60, 3407-3411 (2021)
    PMID: 33124701
  15. Yamanaka S, Murai H, Saito D, Abe G, Tokunaga E, Iwasaki T, Takahashi H, Takeda H, Suzuki T, Shibata N, Tamura K, Sawasaki T.
    Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neo-substrate PLZF.
    EMBO journal. 40, e105375 (2021)
    PMID: 33470442
  16. Imada T, Shimi T, Kaio A, Saeki Y, *Kimura H.
    RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells.
    Genes Cells 26, 298-312 (2021)
    PMID: 33608942
  17. Arafiles JVV, Hirose H, Hirai Y, Kuriyama M, Sakyiamah MM, Nomura W, Sonomura K, Imanishi M, Otaka A, Tamamura H, *Futaki S.
    Discovery of a macropinocytosis-inducing peptide potentiated by medium-mediated intramolecular disulfide formation.
    Angew. Chem. Int. Ed. Engl. 60, 11928-11936 (2021)
    PMID: 33629482
  18. Kowada T, Arai K, Yoshimura A, Matsui T, Kikuchi K, *Mizukami S.
    Optical manipulation of subcellular protein translocation using a photoactivatable covalent labeling system.
    Angew. Chem. Int. Ed. 60, 11378-11383 (2021)
    PMID: 33644979
  19. Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, *Goto Y, *Yoshida M.
    Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.
    Nat. Chem. Biol. 17,335-343 (2021)
    PMID: 33168978
  20. *Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
    Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling.
    PLoS One. 16, e0248158 (2021)
    PMID: 33662037
  21. Kondo T, Eguchi M, Kito S, Fujino T, Hayashi G, Murakami H.
    cDNA TRAP display for rapid and stable in vitro selection of antibody-like proteins.
    Chem. Commun. 57, 2416-2419 (2021)
    PMID: 33554979
  22. Morihiro K, Ishinabe T, Takatsu M, Osumi H, Osawa T, *Okamoto A.
    Floxuridine Oligomers Activated under Hypoxic Environment.
    J. Am. Chem. Soc. 143, 3340–3347 (2021)
    PMID: 33648338
  23. Kowada T, Watanabe T, Liu R, *Mizukami S.
    Protocol for synthesis and use of a turn-on fluorescent probe for quantifying labile Zn2+ in the Golgi Apparatus in live cells.
    STAR Protoc. 2, 100395 (2021)
  24. Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, *Tokunaga F.
    Crosstalk between NDP52 and LUBAC in innate immune responses, cell death, and xenophagy.
    Front Immunol. 12, 635475 (2021)
    PMID: 33815386
  25. Kamo N, Kujirai T, Kurumizaka H, Murakami H, *Hayashi G, *Okamoto A.
    Organoruthenium-Catalyzed Chemical Protein Synthesis to Elucidate the Functions of Epigenetic Modifications on Heterochromatin Factors.
    Chem. Sci. 12, 5926-5937 (2021)
  26. Yoshimoto R, Chhipi-Shrestha JK, Schneider-Poetsch T, Furuno M, Maxwell Burroughs A, Noma S, Suzuki H, Hayashizaki Y, Mayeda A, Nakagawa S, Kaida D, Iwasaki S, *Yoshida M.
    Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation.
    Cell Chem. Biol. 28, 1356-1365 (2021)
    PMID: 33784500
  27. Sakakibara I, Yanagihara Y, Himori K, Yamada T, Sakai H, Sawada Y, Takahashi H, Saeki N, Hirakawa H, Yokoyama A, Fukada S, Sawasaki T, Imai Y.
    Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4.
    iScience. 24, 102303 (2021)
    PMID: 33870126
  28. Rodriguez Carvajal A, Grishkovskaya I, Gomez Diaz C, Vogel A, Sonn-Segev A, Kushwah MS, Schodl K, Deszcz L, Orban-Nemeth Z, Sakamoto S, Mechtler K, Kukura P, Clausen T, *Haselbach D, *Ikeda F.
    The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains.
    eLife 10, e60660 (2021)
    PMID: 34142657
  29. Li Y, Okatsu K, Fukai S, *Sato Y.
    Structural basis for specific recognition of K6-linked polyubiquitin chains by the TAB2 NZF domain.
    Biophys J. 120, 3355-3362 (2021)
    PMID: 34242591
  30. Ichikawa Y, Hiramatsu M, Mita Y, Makishima M, Matsumoto Y, Masumoto Y, Muranaka A, Uchiyama M, Hashimoto Y, *Ishikawa M.
    meta-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discovery.
    Org. Biomol. Chem. 19, 446-456 (2021)
    PMID: 33331380
  31. Tsukumo Y,# Tsuji G,# Yokoo H, Shibata N, Ohoka N, Demizu Y, *Naito M.
    Protocols for synthesis of SNIPERs and the methods to evaluate the anticancer effects.
    Methods Mol. Biol. 2365, 331-347 (2021)
    PMID: 34432253
  32. Morimoto D, Walinda E, Takashima S, Nishizawa M, Iwai K, Shirakawa M, *Sugase K.
    Structural dynamic heterogeneity opolyubiquitin subunits affects phosphorylation susceptibility.
    Biochemistry 60, 573-583 (2021)
    PMID: 33616406
  33. *Pradipta A R, Ahmadi P, Terashima K, Muguruma K, Fujii M, Ichino T, Maeda S, *Tanaka K.
    Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation.
    Chem. Sci. 12, 5438-5449 (2021)
  34. Pradipta A R, *Tanaka K.
    Application of acrolein imines to organic synthesis, biofunctional studies, and clinical practice.
    Chem. Rec. 21, 646-662 (2021)
    PMID: 33769681
  35. *Suzuki M, Suzuki T, Watanabe M, Hatakeyama S, Kimuura S, Nakazono A, Homma A, Nakamaru Y, Homma A.
    Role of intracellular zinc in molecular and cellular function in allergic inflammatory diseases.
    Allergol. Int. 70, 190-200 (2021)
    PMID: 33127267
  36. Gomez Diaz C, Jonsson G, Schodl K, Deszcz L, Bestehorn A, Eislmayr K, Almagro J, Kavirayani A, Seida M, Fennell ML, Hagelkrueys A, Kovarik P, Penninger MJ, *Ikeda F.
    The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.
    iScience. 24, 103241 (2021)
    PMID: 34755089
  37. *Nakazono A, Nakamaru Y, Ramezanpour M, Kondo T, Watanabe M, Hatakeyama S, Kimura S, Honma A, Wormald PJ, Vreugde S, Suzuki M, Homma A.
    Fluticasone propionate suppresses Poly(I:C)-induced ACE2 in primary human nasal epithelial cells.
    Front. Cell. Infect. Microbiol. 11, 655666 (2021)
    PMID: 33981629
  38. *Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K,Tokunaga F.
    Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
    Inflamm Res. 70, 539-541 (2021)
    PMID: 33811487
  39. Toyama T, Hoshi T, Noguchi T, Saito Y, Matsuzawa A, Naganuma A, *Hwang G W.
    Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia.
    Sci. Rep. 11, 9832 (2021)
    PMID: 33972601
  40. Hirata Y, Takahashi M, Yamada Y, Matsui R, Inoue A, Ashida R, Noguchi T, *Matsuzawa A.
    trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway.
    Sci. Rep. 11, 10350 (2021)
    PMID: 33990641
  41. Kumamoto S, *Nishiyama A, Chiba Y, Miyashita R, Konishi C, Azuma Y, *Nakanishi M.
    HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation.
    Nucleic Acids Research 49, 5003-5016 (2021)
    PMID: 33872376
  42. Xu H,# Ohoka N,# Yokoo H, Nemoto K, Ohtsuki T, Matsufuji H, Naito M, Inoue T, *Tsuji G, *Demizu Y.
    Development of agonist-based PROTACs targeting liver X receptor.
    Front. Chem. 9, 674967 (2021)
    PMID: 34124002
  43. Nakane K, *Sato S, Niwa T, Tsushima M, Tomoshige S, Taguchi H, Ishikawa M, Nakamura H.
    Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen.
    J. Am. Chem. Soc. 143, 7726-7731 (2021)
    PMID: 33904715
  44. Shimada T, Kudoh Y, Noguchi T, Kagi T, Suzuki M, Tsuchida M, Komatsu H, Takahashi M, Hirata Y, *Matsuzawa A.
    The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1.
    Int. J. Mol. Sci. 22, 5796 (2021)
    PMID: 34071450
  45. Inagaki H, *Miyamoto K, Ando N, Murakami K, Sugisawa K, Yumoto E, Teruya M, Uchida K, Nobuki K, Kaji T, Takaoka Y, Hojo Y, Shinya T, Galis I, Nozawa A, Sawasaki T, Nojiri H, Ueda M, Okada K.
    Deciphering OPDA signaling components in the momilactone-producing moss Calohypnum plumiforme.
    Front. Plant Sci. 12, Article 688565 (2021) (Invited Article)
    PMID: 34135933
  46. Wang L, Liu S, Xu J, Watanabe N, Mayo KH, *Li J, *Li X.
    Emodin inhibits aggregation of amyloid-β peptide 1-42 and improves cognitive deficits in Alzheimer's disease transgenic mice.
    J. Neurochem. 157, 1992-2007 (2021)
    PMID: 32799401
  47. Kamo N, *Hayashi G, *Okamoto A.
    Silyl-Protected Propargyl Glycine for Multiple Labeling of Peptides by Chemoselective Silyl-Deprotection.
    Tetrahedron Lett. 73, 153093 (2021)
  48. Morimoto J, Miyamoto K, Ichikawa Y, Uchiyama M, Makishima M, Hashimoto Y, *Ishikawa M.
    Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog.
    Sci. Rep. 11, 12697 (2021)
    PMID: 34135380
  49. Wilke J, Kawamura T, Xu H, Brause A, Friese A, Metz M, Schepmann D, Wünsch B, Artacho-Cordón A, Nieto FR, Watanabe N, Osada H, Ziegler S, *Waldmann H .
    Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.
    Cell Chem. Biol. 28, 848-854.e5 (2021)
    PMID: 33567254
  50. *Yokoo H, Hirano M, Ohoka N, Misawa T, *Demizu Y.
    Structure-activity relationship study of amphipathic antimicrobial peptides using helix-destabilizing sarcosine.
    J. Pept. Sci. e3360, 1-6 (2021)
    PMID: 34164880
  51. Nishiyama K, *Maekawa M (co-first), Nakagita T, Nakayama J, Kiyoi T, Chosei M, Murakami A, Kamei Y, Takeda H, Takada Y, *Higashiyama S.
    CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.
    Life Sci. Alliance. 4, e202101095 (2021)
    PMID: 34187934
  52. Saito R, Hayashi K, Nomoto H, Nakayama M, Takaoka Y, Saito H, Yamagami S, Muto T, *Ueda M.
    Extended JAZ degron sequence for plant hormone binding in jasmonate co-receptor of tomato SlCOI1-SlJAZ.
    Sci. Rep. 11, 13612 (2021)
    PMID: 34193940
  53. Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y.
    CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells.
    J Biol. Chem. 297, 100803 (2021)
    PMID: 34022224
  54. Takayama KI, Honma T, Suzuki T, Kondoh Y, Osada H, Suzuki Y, Yoshida M, Inoue S.
    Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth.
    Cancer Res. 81, 3495-3508 (2021)
    PMID: 33975881
  55. Yoshida Y, Asahina M, Murakami A, Kawawaki J, Yoshida M, Fujinawa R, Iwai K, Tozawa R, Matsuda N, Tanaka K and Suzuki T.
    Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.
    Proc. Natl. Acad. Sci. USA 118, e2102902118 (2021)
    PMID: 34215698
  56. *Beziat V, Rapaport F, Hu J, Titeux M, Bonnet des Claustres M, Bourgey M, Griffin H, Bandet E, Ma CS, Sherkat R, Rokni-Zadeh H, Louis DM, Changi-Ashtiani M, Delmonte OM, Fukushima T, Habib T, Guennoun A, Khan T, Bender N, Rahman M, About F, Yang R, Rao G, Rouzaud C, Li J, Shearer D, Balogh K, Al Ali F, Ata M, Dabiri S, Momenilandi M, Nammour J, Alyanakian MA, Leruez-Ville M, Guenat D, Materna M, Marcot L, Vladikine N, Soret C, Vahidnezhad H, Youssefian L, Saeidian AH, Uitto J, Catherinot E, Navabi SS, Zarhrate M, Woodley DT, Jeljeli M, Abraham T, Belkaya S, Lorenzo L, Rosain J, Bayat M, Lanternier F, Lortholary O, Zakavi F, Gros P, Orth G, Abel L, Pretet JL, Fraitag S, Jouanguy E, Davis MM, Tangye SG, Notarangelo LD, Marr N, Waterboer T, Langlais D, Doorbar J, Hovnanian A, Christensen N, Bossuyt X, Shahrooei M, *Casanova JL.
    Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
    Cell 184, 3812-3828 (2021)
    PMID: 34214472
  57. Koyama K, Hayashi G, Ueda H, Ota S, Nagae G, Aburatani H, *Okamoto A.
    Base-Resolution Analysis of 5-Hydroxymethylcytidine by Selective Oxidation and Reverse Transcription Arrest.
    Org. Biomol. Chem. 19, 6478-6486 (2021)
    PMID: 34241617
  58. Ishikawa R, Yasuda M, Sasaki S, Ma Y, Nagasawa K, *Tera M.
    Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease.
    Chem. Commun. 57, 7236-7239 (2021)
    PMID: 34263271
  59. Walinda E, Morimoto D, Sorada T, Iwai K, Sugase K.
    Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures.
    Protein Expr. Purif. 187,105953 (2021)
    PMID: 34390872
  60. Obara S, Nakane K, Fujimura C, Tomoshige S, Ishikawa M, *Sato S.
    Functionalization of Human Serum Albumin by Tyrosine Click.
    Int. J. Mol. Sci. 22, 8676-8676 (2021)
    PMID: 34445381
  61. Yokoo H,# Ohoka N,# Takyo M, Ito T, Tsuchiya K, Kurohara T, Fukuhara K, Inoue T, Naito M, *Demizu Y.
    Peptide stapling improves the sustainability of a peptide-based chimeric molecule that induces targeted protein degradation.
    Int. J. Mol. Sci. 22, 8772 (2021)
    PMID: 34445478
  62. Yoshida K, Kondoh Y, Nakano T, Bolortuya B, Kawabata S, Iwahashi F, Nagano E, Osada H.
    New abscisic acid derivatives revealed adequate regulation of stomatal, transcriptional, and developmental responses to conquer drought.
    ACS Chem. Biol. 16, 1566-1575 (2021)
    PMID: 34379974
  63. Kondo T, Eguchi M, Tsuzuki N, Murata N, Fujino T, Hayashi G, *Murakami H.
    Construction of a Highly Diverse mRNA Library for In Vitro Selection of Monobodies.
    bio-protocol 11, e4125 (2021)
    PMID: 34541043
  64. Yamamoto K, Goyama S, Asada S, Fujino T, Yonezawa T, Sato N, Takeda R, Tsuchiya A, Fukuyama T, Tanaka Y, Yokoyama A, Toya H, Kon A, Nannya Y, Onoguchi-Mizutani R, Nakagawa S, Hirose T, Ogawa S, Akimitsu N, *Kitamura T.
    A histone modifier ASXL1 interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.
    Cell Rep. 36, 109576 (2021)
    PMID: 34433054
  65. Anzai H, *Terai T, Wakabayashi-Nakao K, Noguchi T, Kumachi S, Tsuchiya M, *Nemoto N.
    Interleukin-17A Peptide Aptamers with an Unexpected Binding Moiety Selected by cDNA Display under Heterogenous Conditions.
    ACS Med. Chem. Lett. 12, 1427-1434 (2021)
    PMID: 34531951
  66. Iwata T, Hirose H, Sakamoto K, Hirai Y, Arafiles JVV, Akishiba M, Imanishi M, *Futaki S.
    Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides.
    Angew. Chem. Int. Ed. Engl. 60, 19804-19812 (2021)
    PMID: 34114295
  67. Morihiro K, Moriyama Y, Nemoto Y, Osumi H, *Okamoto A.
    anti-syn Unnatural Base Pair Enables Alphabet-Expanded DNA Self-Assembly.
    J. Am. Chem. Soc. 143, 14207-14217 (2021)
    PMID: 34450012
  68. *Pradipta A R, *Tanaka K.
    Biofunctional chemistry and reactivity of biogenic acrolein for cancer diagnosis and therapy.
    Chem. Commun. 57, 9798-9806 (2021)
    PMID: 34581321
  69. Tokuchi K, Kitamura S, Maeda T, Watanabe M, Hatakeyama S, Kano S, Tanaka S, Ujiie H, *Yanagi T.
    Loss of FAM83H promotes cell migration and invasion in cutaneous squamous cell carcinoma via impaired keratin distribution.
    J. Dermatol. Sci. 104, 112-121 (2021)
    PMID: 34657752
  70. Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A.
    Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.
    Cancer Sci. 112, 4303-4316 (2021)
    PMID: 34289205
  71. Tan FHP, Ting ACJ, Leow BG, Najimudin N, Watanabe N, *Azzam G.
    Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer’s disease.
    J. Ethnopharmacology 279, 114389 (2021)
    PMID: 34217797
  72. Yokoo H, *Shibata N, Endo A, Ito T, Yanase Y, Murakami Y, Fujii K, Hamamura K, Saeki Y, *Naito M, *Aritake K, *Demizu Y.
    Discovery of a highly potent and selective PROTAC targeting hematopoietic prostaglandin D synthase via in silico design.
    J. Med. Chem. 64, 15868-15882 (2021)

    PMID: 34652145

  73. Kakihara K, Asamizu K, Moritsugu K, Kubo M, Kitaguchi T, Endo A, Kidera A, Ikeguchi M, Kato A, *Komada M, *Fukushima T
    Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain.
    Commun. Biol. 4, 1272 (2021)
    PMID: 34750505
  74. *Kanazawa N, Hemmi H, Kinjo N, Ohnishi H, Hamazaki J, Mishima H, Kinoshita A, Mizushima T, Hamada S, Hamada K, Kawamoto N, Kadowaki S, Honda Y, Izawa K, Nishikomori R, Tsumura M, Yamashita Y, Tamura S, Orimo T, Ozasa T, Kato T, Sasaki I, Fukuda-Ohta Y, Wakaki-Nishiyama N, Inaba Y, Kunimoto K, Okada S, Taketani T, Nakanishi K, Murata S, Yoshiura K, *Kaisho T.
    Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency.
    Nature Comm.12, 6819 (2021)
    PMID: 34819510
  75. Sakamoto T, Fukui Y, Kondoh Y, Honda K, Shimizu T, Hara T, Hayashi T, Saitoh Y, Murakami Y, Inoue J, Kaneko S, Osada H, Seiki M.
    Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock.
    Commun. Biol. 4, 1165 (2021)
    PMID: 34621018
  76. Kwong MMY, Lee JW, Samian MR, Wahab H, Watanabe N, Ong EBB.
    Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span.
    Cells 10, 2718 (2021)
    PMID: 34685698
  77. Tan FHP, Hadri NAB, Najimudin N, Watanabe N, *Azzam G.
    Ethyl caffeate ameliorated Aβ42-associated toxicity in PC12 cells and Drosophila melanogaster.
    Geriatr. Gerontol. Int. 21, 1125-1130 (2021)
    PMID: 34699118
  78. Moon JY, Adams E, Miyazaki T, Kondoh Y, Muroi M, Watanabe N, Osada H, Shin R.
    Cesium tolerance is enhanced by a chemical which binds to BETA- GLUCOSIDASE 23 in Arabidopsis thaliana.
    Sci. Rep. 11, 21109 (2021)
    PMID: 34702872
  79. Shimizu N, Asatuma-Okumura T, Yamamoto J, Yamaguchi Y, *Handa H,*Ito T.
    PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates.
    Commun Biol. 4, 1277 (2021)

    PMID: 34764413
  80. Yoshida J, Ohishi T, Abe H, Ohba S, Inoue H, Usami I, Amemiya M, Oriez R, Sakashita C, Dan S, Sugawara M, Kawaguchi T, Ueno J, Asano Y, Ikeda A, Takamatsu M, Amori G, Kondoh Y, Honda K, Osada H, Noda T, Watanabe T, Shimizu T, Shibasaki M, Kawad
    M.
    Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment.
    iScience 24, 103497 (2021)
    PMID: 34934919
  81. Kuriyama Y, *Shimizu A, Kanai S, Oikawa D, Motegi SI, Tokunaga F, Ishikawa O.
    Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease.
    Sci Rep. 11, 23146 (2021)
    PMID: 34848794
  82. Sasaki S, Kitamura J, Endo H, Shiraishi A, Ikebukuro K, Mizutani T, *Tera M.
    Identification of G-quadruplex sequences in severe acute respiratory syndrome coronavirus 2.
    Translat Regulat Sci.3,89-92 (2021)
  83. Kori S, Shibahashi Y, Ekimoto T, Nishiyama A, Yoshimi S, Yamaguchi K, Nagatoishi S, Ohta M, Tsumoto K, Nakanishi M, Defossez PA, Ikeguchi M, *Arita K.
    Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.
    Bioorg Med. Chem. 52, 116500 (2021)
    PMID: 34801826
  84. Lee JW, Ong TG, Samian MR, Teh AH, Watanabe N, Osada H, Ong EBB.
    Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisoae.
    Sci. Rep. 11, 24148 (2021)
    PMID: 34921163


Review Articles

  1. Takeuchi J, Fukui K, Seto Y, *Takaoka Y, *Okamoto M.
    Ligand-receptor interactions in plant hormone signaling.
    The Plant Journal, 106, 290 (2021)
  2. Naito M, Murata S.
    Gluing proteins for targeted degradation.
    Cancer Cell 39, 19-21 (2021)
    PMID: 33434510
  3. Ohnishi M, Yamano K, *Sato M, *Matsuda N, *Okamoto K.
    Molecular mechanisms and physiological functions of mitophagy.
    EMBO J 40, e104705 (2021)
    PMID: 33438778
  4. Iwai K.
    Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death. ~Discovery-In-Context Review ~
    FEBS J. 288, 1060-1069 (2021)
    PMID: 32627388
  5. Yokoo H, Hirano M, Misawa T *Demizu Y.
    Helical antimicrobial peptide foldamers containing non-proteinogenic amino acids.
    ChemMedChem 16, 1226-1233 (2021)
    PMID: 33565721
  6. Tomoshige S, *Ishikawa M.
    PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders.
    Angew. Chem. Int. Ed. 60, 3346-3354 (2021)
    PMID: 32410219
  7. Iwai K.
    LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling.
    Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 97, 120-133 (2021)
    PMID: 33692228
  8. Sato T, Ito T, *Handa H.
    Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.
    Front. Cell Dev. Biol. 9, 629326 (2021)
    PMID: 33777938
  9. Sakakibara I, Yanagihara Y, Himori K, Yamada T, Sakai H, Sawada Y, Takahashi H, Saeki N, Hirakawa H, Yokoyama A, Fukada S, Sawasaki T, *Imai Y.
    Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4.
    iScience. 24, 102303 (2021)
    PMID: 33870126
  10. Futaki S.
    Functional Peptides That Target Biomembranes: Design and Modes of Action.
    Chem. Pharm. Bull. 69, 601-607 (2021)
    PMID: 34193708
  11. *Nishiyama A, *Nakanishi M.
    Navigating the DNA methylation landscape of cancer.
    Trends Genet. 37, 1012-1027 (2021)
    PMID: 34120771
  12. Kagi T, Noguchi T, *Matsuzawa A.
    Mechanisms of gefitinib-induced interstitial pneumonitis: why and how the TKI perturbs innate immune systems?
    Oncotarget 12, 1321-1322 (2021)
    PMID: 34194630
  13. *Tomoshige S, Ishikawa M.
    In Vivo Synthetic Chemistry of Proteolysis Targeting Chimeras (PROTACs)
    Bioorg. Med. Chem. 41, 116221 (2021)
    PMID: 34034148
  14. Ito T, Yamaguchi Y, *Handa H.
    Exploiting ubiquitin ligase Cereblon as a target for small-molecule compounds in medicine and chemical biology.
    Cell Chem. Biol. 28, 987-999 (2021)
    PMID: 34033753
  15. Utsugi Y, *Miyamae Y.
    Strategies for Post-Translational Control of Protein Expression and their Applications.
    Appl. Sci. 11, 8300 (2021)
  16. *Yamano K, Kojima W.
    Molecular functions of autophagy adaptors upon ubiquitin-driven mitophagy.
    Biochim Biophys Acta Gen Subj 1865, 129972 (2021)
    PMID: 34332032
  17. *Schneider-Poetsch T, Chhipi-Shrestha JK, Yoshida M.
    Splicing modulators: on the way from nature to clinic.
    J Antibiot. 74, 603-616 (2021)
    PMID: 34345042
  18. Morishita R, Takahashi H, Sawasaki T.
    Cell-free based protein array technology. In: Suzuki T, Poignard C, Chaplain M, Quaranta V (eds).
    Methods of Mathematical Oncology, Fusion of Mathematics and Biology, Osaka, Japan.
    Springer Proceedings in Mathematics & Statistics. 255-265, (2021)
  19. Fuseya Y,  Iwai K.
    Biochemistry, Pathophysiology, and Regulation of Linear Ubiquitination: Intricate Regulation by Coordinated Functions of the Associated Ligase and Deubiquitinase.
    Cells 10, 2706 (2021)
    PMID: 34685685

Original Articles

  1. Takaoka Y, Suzuki K, Nozawa A, Takahashi H, Sawasaki T, Ueda M.
    Protein-protein interactions between jasmonate-related master regulator MYC and transcriptional mediator MED25 depend on a short binding domain.
    J Biol Chem. 298, 101504 (2022)
    PMID: 34929168
  2. #Ohoka N, #Yokoo H, Okuhira K, Demizu Y, *Naito M.
    Molecular design, synthesis and evaluation of SNIPER(ER) that induces targeted protein degradation of ERa.
    Methods Mol. Biol. 2418, 363-382 (2022)
    PMID: 35119675
  3. Kagi T, Naganuma R, Inoue A, Noguchi T, Hamano S, Sekiguchi Y, Hwang G W, Hirata Y, *Matsuzawa A.
    The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages.
    J. Antibiot. 75, 29-39 (2022)
    PMID: 34824374
  4. *Pradipta A R, Michiba H, Kubo A, Fujii M, Tanei T, Morimoto K, Shimazu K, *Tanaka K.
    The secon-generation click-to-sense probe for intraoperative diagnosis of breast cancer tissues based on acrolein targeting.
    Bull. Chem. Soc. Jpn. (2022)
  5. Mizumoto Y, Sakamoto R, Nagata A, Sakane S, Kittaka A, Odagi M, Tera M, Nagasawa K.
    Synthesis of C2-Alkoxy-Substituted 19-Nor Vitamin D 3 Derivatives: Stereoselectivity and Biological Activity
    Biomolecules. 12, 69 (2022)
    PMID: 35053217
  6. Yamanaka S, Horiuchi Y, Matsuoka S, Kido K, Nishino K, Maeno M, Shibata N, Kosako H, *Sawasaki T.
    A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues.
    Nature Communications 13, 183 (2022)
    PMID: 35013300
  7. Naganuma M, *Ohoka N, Tsuji G, Tsujimura H, Matsuno K, Inoue T, Naito M, *Demizu Y.
    Development of chimeric molecules that degrade the estrogen receptor using decoy oligonucleotide ligands.
    ACS Med. Chem. Lett. 13, 134-139 (2022)
    PMID: 35059133
  8. Taniguchi S, Ito Y, Kiritani H, Maruo A, Sakai R, Ono Y, Fukuda R, *Okiyoneda T.
    The ubiquitin ligase RNF34 participates in the peripheral quality control of CFTR.
    Front. Mol. Biosci. 9, 840649 (2022)
    PMID: 35355508
  9. Huang Y, Yokoe H, Kaiho-Soma A, Takahashi K, Hirasawa Y, Morita H, *Ohtake F, *Kanoh N.
    Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation.
    Bioconjug Chem. 33, 142-151 (2022)
    PMID: 34878263
  10. Nitschke S, Sullivan MA, Mitra S, Marchioni CR, Lee JPY, Smith BH, Ahonen S, Wu J, Chown EE, Wang P, Petković S, Zhao X, DiGiovanni LF, Perri AM, Israelian L, Grossman TR, Kordasiewicz H, Vilaplana F, Iwai K, Nitschke F, Minassian BA.
    Glycogen synthase downregulation rescues the amylopectinosis of murine RBCK1 deficiency.
    Brain, awac017 (2022)

    PMID: 35084461
  11. Hasegawa Y, Reyes TH, Uemura T, Baral A, Fujimaki A, Luo Y, Morita Y, Saeki Y, Maekawa S, Yasuda S, Mukuta K, Fukao Y, Tanaka K, Nakano A, Takagi J, Bhalerao RP, Yamaguchi J, Sato T.
    The TGN/EE SNARE protein SYP61 and the ubiquitin ligase ATL31 cooperatively regulate plant responses to carbon/nitrogen conditions in Arabidopsis.
    Plant Cell. 34, 1354-1374 (2022)
    PMID: 35089338
  12. Zou X, Liu Y, Di J, Wei W, Watanabe N, Li J, Li X.
    ZMIZ2 promotes the development of triple-receptor negative breast cancer.
    Cancer Cell Int. 22, 52 (2022)
    PMID: 35101047
  13. Tsunoda T, Riku M, Yamada N, Tsuchiya H, Tomita T, Suzuki M, Kizuki M, Inoko A, Ito H, Murotani K, Murakami H, Saeki Y, *Kasai K.
    ENTREP/FAM189A2 downregulated in breast cancer encodes a new activator for ITCH ubiquitin ligase.
    EMBO Rep. 23, e51182 (2022)
    PMID: 34927784
  14. Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.
    Identification of a small molecule that enhances ferroptosis via inhibition of FSP1.
    ACS Chem. Biol. 17, 483-491 (2022)
    PMID: 35128925
  15. Shioya R, Yomada K, Kido K, Takahashi H, Nozawa A, Miyakawa T, Kosako H, Sawasaki T.
    A simple method for labeling proteins and antibodies with biotin using the proximity biotinylation enzyme TurboID.
    Biochem Biophys Res Commun. 592, 54-59 (2022)
    PMID: 35030423
  16. Hirai K, Yamashita H, *Tomoshige S, Mishima Y, Niwa T, Ohgane K, Ishii M, Kanamitsu K, Ikemi Y, Nakagawa S, Taguchi H, Sato S, Hashimoto Y, *Ishikawa M.
    Conversion of a PROTAC mutant huntingtin degrader into small-molecule hydrophobic tags focusing on drug-like properties.
    ACS Med. Chem. Lett. 13, 396-402 (2022)
    PMID: 35300080
  17. Kodama Y, Takeo S, Fujimoto J, Sato K, Mase N, *Narumi T.
    Synthesis and Structural Characterization of β-Turn Mimics Containing (Z)-Chloroalkene Dipeptide Isosteres.
    J. Org. Chem. 87, 2167-2177 (2022)
    PMID: 35179382
  18. Chhipi-Shrestha JK, Schneider-Poetsch T, Suzuki T, Mito M, Khan K, Dohmae N, *Iwasaki S, *Yoshida M.
    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns.
    Cell Chem. Biol. 29, 259-275 (2022)
    PMID: 34520743
  19. Wei W, Pathak J L, LIU X, Mao T, Watanabe N, Li X, Zhang M, Li J.
    Apigenin, a single active component of herbal extract, alleviates xerostomia via ERα-mediated upregulation of AQP5 activation.
    Front. Pharmacol. 13, 818116 (2022)
    PMID: 35264956
  20. Shinkawa Y, Imami K, Fuseya Y, Sasaki K, Ohmura K, Ishihama Y, Morinobu A, Iwai K.
    ABIN1 is a signal-induced autophagy receptor that attenuates NF-kB activation by recognizing linear ubiquitin chains.
    FEBS Lett. 596, 1147-1164 (2022)
    PMID: 35213742
  21. Shibata N, Cho N, Koyama H, Naito M.
    Development of a degrader against oncogenic fusion protein FGFR3-TACC3.
    Bioorg Med Chem Lett 60, 128584 (2022)
    PMID: 35085722
  22. Sasaki K, Suzuki M, Sonoda T, Schneider-Poetsch T, Ito A, Takagi M, Fujishiro S, Sohtome Y, Dodo K, Umehara T, Aburatani H, Shin-ya K, Nakao Y, Sodeoka M, *Yoshida M.
    Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells.
    Cell Chem. Biol. 29, 1153-1161.e5 (2022)
    PMID: 35728598

Review Articles

  1. *Ohtake F.
    Branched ubiquitin code: from basic biology to targeted protein degradation.
    J Biochem. 171, 361-366 (2022)
    PMID: 35037035
  2. *Matsumoto K, *Yoshida M.
    Mammalian chemical genomics towards identifying targets and elucidating modes-of-action of bioactive compounds.
    Chembiochem 23, e202100561 (2022)
    PMID: 34813140