研究成果
Publications研究成果
論文等研究成果の謝辞に関するお願い
本新学術領域研究により得た研究成果を発表する場合は、Acknowledgment(謝辞)に、科研費による助成を受けた旨を記載してください。
- 論文に関する科研費が本新学術領域研究一つの場合：This work was supported by MEXT KAKENHI Grant Number JP（8桁の課題番号）.
- 論文に関する科研費が複数（日本学術振興会科研費を含む）の場合：This work was supported by MEXT/JSPS KAKENHI Grant Numbers JP（8桁の課題番号）, JP（8桁の課題番号）, and JP（8桁の課題番号）.
（記入例1）
Acknowledgements
We thank the beamline staff of the biological crystallography beamlines of BL41XU of SPring-8 (Hyogo, Japan) for technical help during data collection. This work was supported by JSPS/MEXT KAKENHI (JP16H0XXXX to Y.S., JP18K14YYY to H.T., and JP18H05ZZZ to S.F.), and TTTTT Science Foundation (to Y.S. and K.T.).
（記入例2）
Acknowledgements
We thank S. Sato, K. Ito, and T. Saito for reagents. This research was supported by MEXT/JSPS KAKENHI Grant Numbers JP18K14XXX (H.T.), JP18H05XXX (F.O. and Y.S.), JP19H0XXX (T.I.) and JP21000XXX (K.T.); the TTTTT Science Foundation (Y.S., K.T., and T.I.); and the UUUU Memorial Foundation (Y.S.).
詳しくはこちら
原著論文 / Publication
- Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, Yamagata A, Goto-Ito S, Mishima M, Ito Y, Oka T, Tanaka K, Fukai S.
Structural insights into ubiquitin phosphorylation by PINK1.
Sci. Rep. 8, 10382 (2018)
PMID: 29991771 - Nishiyama Y, Fujii S, Makishima M, Hashimoto Y, Ishikawa M.
Efficient lead finding, activity enhancement and preliminary selectivity control of nuclear receptor ligands bearing a phenanthridinone skeleton.
Int. J. Mol. Sci. 19, 2090 (2018)
PMID: 30021999 - Sohtome Y, Shimazu T, Barjau J, Fujishiro S, Akakabe M, Terayama N, Dodo K, Ito A, Yoshida M, Shinkai Y, Sodeoka M.
Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses.
Chem. Commun. 54, 9202-9205 (2018)
PMID: 30063235 - Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi Y, Arata M, Ito A, Yoshida M, Nagaoka Y, Sumiyoshi T.
Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.
ACS Med. Chem. Lett. 9, 884-888 (2018)
PMID: 30258535 - Shibata N, Shimokawa K, Nagai K, Ohoka N, Hattori T, Miyamoto N, Ujikawa O, Sameshima T, Nara H, Cho N, Naito M.
Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.
Sci. Rep. 8, 13549 (2018)
PMID: 30202081 - Furuta H, Yoshihara H, Fukushima T, Yoneyama Y, Ito A, Worrall C, Girnita A, Girnita L, Yoshida M, Asano T, Komada M, Kataoka N, Chida K, Hakuno F, Takahashi SI.
IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.
Oncotarget 9, 33871-33883 (2018)
PMID: 30338032 - Azuma Y, Imai H, Kawaguchi Y, Nakase I, Kimura H, Futaki S.
Modular redesign of a cationic lytic peptide to promote the endosomal escape of biomacromolecules.
Angew. Chem. Int. Ed. Engl. 57, 12771 (2018)
PMID: 30101453 - Nakamoto Y, Pradipta AR, Mukai H, Zouda M, Watanabe Y, Kurbangalieva A, Ahmadi P, Manabe Y, Fukase K, Tanaka K.
Expanding the applicability of the metal labeling of biomolecules by the RIKEN click reaction: A case study with Gallium-68 positron emission tomography.
ChemBioChem. 19, 2055-2060 (2018)
PMID: 30066425 - Wu W, Sahara K, Hirayama S, Zhao X, Watanabe A, Hamazaki J, Yashiroda H, Murata S.
PAC1‐PAC2 proteasome assembly chaperone retains the core α4–α7 assembly intermediates in the cytoplasm.
Genes to Cells 23, 839–848 (2018)
PMID: 30133132 - Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL.
Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.
PLoS Comput. Biol. 14, e1006532 (2018)
PMID: 30376562 - MacDuff DA, Baldridge MT, Qaqish AM, Nice TJ, Darbandi AD, Hartley VL, Peterson ST, Miner JJ, Iwai K, Virgin HW.
HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection.
J. Virol. 92, pii: e01368-18 (2018)
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Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology.
Adv. Sci. 6, 1801479 (2018)
PMID: 30693189
プレスリリース - Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
Cancer Sci. 109, 4003-4014 (2018)
PMID: 30238564 - Sueoka T, Koyama K, Hayashi G, Okamoto A.
Chemistry-driven Epigenetic Investigation of Histone and DNA Modifications.
Chem. Rec. 18, 1727-1744 (2018)
PMID: 30070422 - Kamo N, Hayashi G, Okamoto A.
Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation.
Angew. Chem. Int. Ed. 57, 16533-16537 (2018)
PMID: 30346110
Highlighted in SYNFACTS 15, 0204 (2018) - Tomita T, Hirayama S, Sakurai Y, Ohte Y, Yoshihara H, Saeki Y, Hamazaki J, Murata S.
Specific modification of aged proteasomes revealed by tag-exchangeable knock-in mice.
Mol. Cell Biol. 39, e00426-18 (2018)
PMID: 30348842 - Shioi R, Toyota Y, Noguchi-Yachide T, Ishikawa M. Yamaguchi T, Makishima M, Hashimoto Y, Ohgane K.
Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands.
Heterocycles 97, 854-864 (2018)
総説論文・書籍 / Review Articles
- *Murata S, *Takahama Y, *Kasahara M, *Tanaka K.
The immunoproteasome and thymoproteasome: functions, evolution and human disease.
Nat. Immunol. 19, 923–931(2018)
PMID: 30104634 - Koizumi S, Hamazaki J, *Murata S.
Transcriptional regulation of the 26S proteasome by Nrf1.
Proc. Jpn. Acad. Ser. B 94, 325–336 (2018)
PMID: 30305478 - Robaa D, Monaldi D, Wössner N, Kudo N, Rumpf T, Schiedel M, Yoshida M, *Jung M.
Opening the selectivity pocket in the human lysine deacetylase sirtuin2 - new opportunities, new questions.
Chem. Rec. 18, 1701-1707 (2018)
PMID: 29931800 - Sueoka T, Koyama K, Hayashi G, *Okamoto A.
Chemistry-driven Epigenetic Investigation of Histone and DNA Modifications.
Chem. Rec. 18, 1727-1744 (2018)
PMID: 30070422
日本語総説/ Review in Japanese
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- 大岡伸通、*内藤幹彦：「標的タンパク質を分解する新たな低分子薬の開発技術」実験医学 第36巻第18号3125－3132 (2018）
- 佐々木克博、*岩井一宏：「多様化するユビキチンコード」医学のあゆみ『蛋白質代謝医学-構造・機能の研究から臨床応用まで』第267巻13号989－995 (2018)
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- *伊藤拓水、半田 宏：「セレブロンモジュレーター」医学のあゆみ『蛋白質代謝医学-構造・機能の研究から臨床応用まで』第267巻13号1076－1081 (2018)
- *佐伯泰：「生体分子の液－液相分離」医学のあゆみ『蛋白質代謝医学-構造・機能の研究から臨床応用まで』第267巻13号1082－1088 (2018)
原著論文 / Publication
- Tomaru U, Konno S, Miyajima S, Kimoto R, Onodera M, Kiuchi S, Murata S, Ishizu A, Kasahara M.
Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells.
Cell Rep. 26, 639-651. e2 (2019)
PMID: 3065037 - Wu M, Chang Y, Hu H, Mu R, Zhang Y, Qin X, Duan X, Li W, Tu H, Zhang W, Wang G, Han Q, Li A, Zhou T, Iwai K, Zhang X Li H.
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores.
Nat. Commun. 10, 273 (2019)
PMID: 30655516 - Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.
Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments.
Nat. Protoc. 14, 415-440 (2019)
PMID: 30635653 - Izuta S, Yamaguchi S, Kosaka T, Okamoto A.
Reversible and Photoresponsive Immobilization of Nonadherent Cells by Spiropyran-Conjugated PEG-Lipids.
ACS Appl. Bio Mater. 2, 33-38 (2019) - Kawaguchi Y, Ise S, Azuma Y, Takeuchi T, Kawano K, Le TK, Ohkanda J, Futaki S.
Dipicolylamine/metal complexes that promote direct cell-membrane penetration of octaarginine.
Bioconjug. Chem. 30, 454-460 (2019)
PMID: 30428256 - Ikeuchi K, Tesina P, Matsuo Y, Sugiyama T, Cheng J, Saeki Y, Tanaka K, Becker T, Beckmann R, Inada T.
Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.
EMBO J. 38, e100276 (2019)
PMID: 30609991 - Hitachi K, Nakatani M, Takasaki A, Ouchi Y, Uezumi A, Ageta H, Inagaki H, Kurahashi H, Tsuchida K.
Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation.
EMBO Rep. 20, e47468 (2019)
PMID: 30622218 - Ohoka N, Ujikawa O, Shimokawa K, Sameshima T, Shibata N, Hattori T, Nara H, Cho N, Naito M.
Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER).
Chem. Pharm. Bull. 67, 203-209 (2019)
PMID: 30369550 - Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.
A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.
J. Biol. Chem. 294, 2988-2996 (2019)
PMID: 30610116 - Otsubo R, Mimuro H, Ashida H, Hamazaki J, Murata S, Sasakawa C.
Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation.
Cell. Microbiol. 21, e12974 (2019)
PMID: 30414351 - Hayashi G, Yanase M, Nakatsuka Y, Okamoto A.
Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold.
Biomacromolecules 20, 1246-1253 (2019)
PMID: 30677290 - Ling F, Bradshaw E, Yoshida M.
Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1.
Sci. Rep. 9, 5433 (2019)
PMID: 30931958 - Takahashi T, Minami S, Tajima K, Tsuchiya Y, Sakai N, Suga K, Hisanaga S, Obayashi N, Fukuda M, Kawahara H.
Cytoplasmic control of Rab-family small GTPases through BAG6.
EMBO Rep. 20, e46794 (2019)
PMID: 30804014 - Ishii N, Walinda E, Iwakawa N, Morimoto D, Iwai K, Sugase K, Shirakawa M.
NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin.
Biomol. NMR Assign. 13, 149-153 (2019)
PMID: 30569274 - Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y.
Rational design of novel amphipathic antimicrobial peptides focused on distribution of cationic amino acid residues.
MedChemComm 10,896-900 (2019)
PMID: 31303986 - Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H.
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem. 62, 3407-3427 (2019)
PMID: 30883102 - Demizu S, Asaka N, Kawahara H, Sasaki E.
TAS-203, an oral phosphodiesterase 4 inhibitor, exerts anti-inflammatory activities in a rat airway inflammation model.
Eur. J. Pharmacol. 849, 22-29 (2019)
PMID: 30716315 - Takahashi TS, Sato Y, Yamagata A, Goto-Ito S, Saijo M, Fukai S.
Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.
Nucleic Acids Res. 47, 3784-3794 (2019)
PMID: 30753618 - Yanase M, Nakatsu K, Cardos C J, Konda Y, Hayashi G, Okamoto A.
Cysteinylprolyl Imide (CPI) Peptide: A Highly Reactive and Easily Accessible Crypto-thioester for Chemical Protein Synthesis.
Chem. Sci. 10, 5967-5975 (2019)
PMID: 31360403 - Yamaguchi S, Higashi K, Azuma T, Okamoto A.
Supramolecular Polymeric Hydrogels for Ultrasound-guided Protein Release.
Biotechnol. J. 14, 1800530 (2019)
PMID: 30810275 - Shu K, Iwamoto N, Honda K, Kondoh Y, Hirano H, Osada H, Ohno H, Fujii N, Oishi S.
Development of mirror-image screening systems for XIAP BIR3 domain inhibitors.
Bioconjug. Chem. 30, 1395-1404 (2019)
PMID: 30888797 - Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H.
Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation.
iScience 15, 95-108 (2019)
PMID: 31055217
プレスリリース - Bai M, Zhao X, Sahara K, Ohte Y, Hirano Y, Kaneko T, Yashiroda H, Murata S.
In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals.
Biomolecules 9, E213 (2019)
PMID: 31159305 - Qi Y, Zhao X, Chen J, Pradipta AR, Wei J, Ruan H, Zhou L, Hsung R P, Tanaka K.
In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6.
Biosci. Biotechnol. Biochem. 83, 1011-1026 (2019)
PMID: 31074699 - Mashita T, Kowada T, Takahashi H, Matsui T, Mizukami S.
Light-wavelength-based Quantitative Control of Dihydrofolate Reductase Activity Using Photochromic Isostere of Inhibitor.
ChemBioChem 20, 1382–1386 (2019)
PMID: 30656808 - Sekiguchi Y, Yamada M, Noguchi T, Noomote C, Tsuchida M, Kudoh Y, Hirata Y, Matsuzawa A.
The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells.
J. Toxicol. Sci. 44, 435-440 (2019)
PMID: 31168030 - Förster T, Shang E, Shimizu K, Sanada E, Schölermann B, Hübecker M, Hahne G, Pascual Lopez Alberca M, Janning P, Watanabe N, Sievers S, Giordanetto F, Shimizu T, Ziegler S, Osada H Waldmann, H.
2-Sulfonylpyrimidines target the kinesin HSET via cysteine alkylation.
Eur. J. Org. Chem. 2019, 5486-5496 (2019)
- Koyano F, Yamano K, Kosako H, Tanaka K, Matsuda N.
Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL.
J. Biol. Chem. 294, 10300-10314 (2019)
PMID: 31110043 - Arii J, Takeshima K, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
Roles of the interhexamer Contact Site for Hexagonal Lattice Formation of the Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication.
J. Virol. 93, e00498-19 (2019)
PMID: 31043535 - Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shin-Ya K, Kimura H, Yoshida M, Murakami S, Kondo Y.
Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.
J. Biochem. 166, 41-50 (2019)
PMID: 30690451 - Misawa T, Ohoka N, Oba M, Yamashita H, Tanaka M, Naito M, Demizu Y.
Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery.
Chem. Commun. 55, 7792-7795 (2019)
PMID: 31210205 - Usami K, Xiao K, Okamoto A.
Efficient Ketose Production by Hydroxyapatite Catalyst in a Continuous Flow Module.
ACS Sustainable Chem. Eng. 7, 3372-3377 (2019) - Mitsui E, Yoshida S, Shinoda Y, Matsumori Y, Tsujii H, Tsuchida M, Wada S, Hasegawa M, Ito A, Mino K, Onuki T, Yoshida M, Sasaki R, Mizukami T.
Identification of ryuvidine as a KDM5A inhibitor.
Sci. Rep. 9, 9952 (2019)
PMID: 31289306 - Hayashishita M, Kawahara H, Yokota N.
BAG6 deficiency induces mis-distribution of mitochondrial clusters under depolarization.
FEBS Open Bio. 9, 1281-1291 (2019)
PMID: 31125507 - Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, Iwasaki S.
Genome-wide survey of ribosome collision.
bioRxiv - Takase S, Kurokawa R, Kondoh Y, Honda K, Suzuki T, Kawahara T, Ikeda H, Dohmae N, Osada H, Shin-Ya K, Kushiro T, Yoshida M, Matsumoto K.
Mechanism of action of prethioviridamide, an anticancer ribosomally synthesized and post-translationally modified peptide with a polythioamide structure.
ACS Chem. Biol. 14, 1819-1828 (2019)
PMID: 31365229 - Arata Y, Watanabe A, Motosugi R, Iemura S, Natsume T, Mukai K, Taguchi T, Hirayama S, Hamazaki J, Murata S.
FAM48A mediates compensatory autophagy induced by proteasome impairment.
Genes to Cells 24, 559–568 (2019)
PMID: 31210371 - Sasaki K, Himeno A, Nakagawa T, Sasaki Y, Kiyonari H, Iwai K.
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nat. Commun. 10, 3878 (2019)
PMID: 31462647
プレスリリース - Yoshida K, Kondoh Y, Iwahashi F, Nakano T, Honda K, Nagano E, Osada H.
Abscisic acid derivatives with different alkyl chain lengths activate distinct abscisic acid receptor subfamilies.
ACS Chem. Biol. 14, 1964-1971 (2019)
PMID: 31497942 - Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T.
The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.
J. Biol. Chem. 294, 14135–14148 (2019)
PMID: 31366726 - Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S.
A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.
J. Biol. Chem. 294, 14562-14573 (2019)
PMID: 31371451 - Masuda Y, Saeki Y, Arai N, Kawai H, Kukimoto I, Tanaka K, Masutani C.
Stepwise multipolyubiquitantion of p53 by the E6AP-E6 ubiquitin ligase complex.
J. Biol. Chem. 294, 14860-14875 (2019)
PMID: 31492752 - Takeshima K, Arii J (contributed equally), Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication.
J. Virol. 93, e01290-19 (2019)
PMID: 31391274 - Kamo N, Hayashi G, Okamoto A.
Chemical Synthesis of Cys-Containing Protein via Chemoselective Deprotection with Different Palladium Complexes.
Org. Lett. 21, 8378-8382 (2019)
PMID: 31560553
- Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H.
p63 is a cereblon substrate involved in thalidomide teratogenicity.
Nat. Chem. Biol. 15, 1077-1084 (2019)
PMID: 31591562
プレスリリース - Yokosawa T, Yamada M, Noguchi T, Suzuki S, Hirata Y, Matsuzawa A.
Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation.
J. Antibiotics 72, 848-852 (2019)
PMID: 31371783 - Jarzebska N A, Yamaguchi S, Izuta S, Kosaka T, Yamahira S, Nagamune T, Okamoto A.
Photo-responsive materials with strong cell trapping ability for light-guided manipulation of nonadherent cells.
Biomater. Sci. 7, 4514-4518 (2019)
PMID: 31602442 - Chulakova D R, Pradipta AR, Lodochnikova OA, Kuznetsov DR, Bulygina KS, Smirnov IS, Usachev KS, Latypova LZ, Kurbangalieva AR, Tanaka K.
Facile access to optically active 2,6-dialkyl-1,5-diazacyclooctanes.
Chem. Asian J. 14, 4048-4054 (2019)
PMID: 31381243 - Goto C, Hirano M, Hayashi K, Kikuchi Y, Hara-Kudo Y, Misawa T, Demizu Y.
Development of amphipathic antimicrobial peptide foldamers based on Magainin 2 sequence.
ChemMedChem 14,1911-1916 (2019)
PMID: 31667994 - Kamada Y, Fukuda R, Okiyoneda T.
ELISA Based Protein Ubiquitylation Measurement.
Bio-protocol 9, e3430 (2019) - Yang N, Liu S, Qin T, Liu X, Watanabe N, Mayo KH, Li J, Li X.
SUMO3 Modification by PIAS1 Modulates Androgen Receptor Cellular Distribution and Stability.
Cell Commun. Signal. 17, 153 (2019)
PMID: 31752909 - Nomura S, Takahashi H, Suzuki J, Kuwahara M, Yamashita M, Sawasaki T.
Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro.
Sci. Rep. 9,17335 (2019)
PMID: 31758034 - Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin AC, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y.
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.
Cell Rep. 29, 2901-2916.e6 (2019)
PMID: 31775054 - Abe T, Shizu R, Sasaki T, Shimizu Y, Hosaka T, Kodama S, Matsuzawa A, Yoshinari K.
Functional interaction between PXR and YAP in xenobiotic-dependent liver hypertrophy and drug metabolism.
J. Pharmacol. Exp. Ther. 371, 590-601(2019)
PMID: 31533970 - Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N.
Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.
EMBO Rep. 20, e47728 (2019)
PMID: 31602805
プレスリリース - Ohoka N, Tsuji G, Shoda T, Fujisato T, Kurihara M, Demizu Y, Naito M.
Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins.
ACS Chem. Biol. 14, 2822-2832 (2019)
PMID: 31580635 - Kwong MMY, Lee JW, Samian MR, Watanabe N, Osada H, Ong EBB.
Comparison of microplate- and bottle-based methods to age yeast for chronological life span assays.
J. Microbiol. Methods. 167 105743 (2019)
PMID: 31629019 - Arata Y, Watanabe A, Motosugi R, Murakami R, Goto T, Hori S, Hirayama S, Hamazaki J, Murata S.
Defective induction of the proteasome associated with T‐cell receptor signaling underlies T‐cell senescence.
Genes to Cells 24, 801–813 (2019)
PMID: 31621149 - Sato Y, Tsuchiya H, Yamagata A, Okatsu K, Tanaka, K, Saeki Y, Fukai S.
Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4.
Nat. Commun. 10, 5708 (2019)
PMID: 31836717
プレスリリース
http://www.iam.u-tokyo.ac.jp/press_release/191213/
http://www.igakuken.or.jp/topics/2019/1213.html
http://www.igakuken.or.jp/english/topics/2019/e-1213.html - Imoto T, Muramatsu M, Miyasaka H, Mizukami S, Kikuchi K.
Improvement in Photostability of Fluorescein by Lanthanide Ions based on Energy Transfer-Based Triplet State Quenching
Chem. Lett. 48, 1181–1184 (2019)
総説論文・書籍 / Review・Book
- *Yoshida M.
Recent advances in target identification of bioactive natural products.
Biosci. Biotechnol. Biochem. 83, 1-9 (2019)
PMID: 30343630 - Ohtake F, Tsuchiya H, Tanaka K, *Saeki Y.
Methods to measure ubiquitin chain length and linkage.
Methods Enzymol. 618, 105-133 (2019)
PMID: 30850048 - Yoshida Y, Saeki Y, Tsuchiya H, *Tanaka K.
TR-TUBE system: Method for detecting ubiquitination activity and identifying ubiquitinated substrates.
Methods Enzymol. 618, 135-147 (2019)
PMID: 30850049 - Shibata N, Ohoka N, Hattori T, *Naito M.
Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein.
Chem. Pharm. Bull. 67, 165-172 (2019)
PMID: 30827996 - *Naito M, Ohoka N, Shibata N.
SNIPERs-Hijacking IAP activity to induce protein degradation.
Drug Discov. Today: Technol. 31, 35-42 (2019)
PMID: 31200857 - Motosugi R, *Murata S.
Dynamic Regulation of Proteasome Expression.
Front. Mol. Biosci. 6, 30 (2019)
PMID: 31119134 - *Inada T.
The mechanism for recycling tRNAs on stalled ribosomes.
Nat. Struc. Mol. Biol. 26, 340-342 (2019)
PMID: 31011210 - Wei W, Rasul A, Sadiqa A, Sarfraz I, Hussain G, Nageen B, Liu X, Watanabe N, Selamoglu Z, Ali M, *Li X, *Li J.
Curcumol: From Plant Roots to Cancer Roots.
Int. J. Biol. Sci. 15, 1600-1609 (2019)
PMID: 31360103 - Asatsuma-Okumura T, Ito T (co-1st author), *Handa H.
Molecular mechanisms of cereblon-based drugs.
Pharmacol. Ther. 202, 132-139. (2019)
PMID: 31202702 - *Yashiroda Y, Yoshida M.
Intraspecies cell-cell communication in yeast.
FEMS Yeast Res. 19, pii: foz071 (2019)
PMID: 31688924 - *Naito M, Ohoka N, Shibata N, Tsukumo Y.
Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs.
Front. Chem. 7, 849 (2019)
PMID: 31921772 - *Inada T.
The proteasome's balancing act.
Nat. Plants 5,1203-1204 (2019)
PMID: 31740771 - Ageta H, *Tsuchida K.
Post-translational modification and protein sorting to small extracellular vesicles including exosomes by ubiquitin and UBLs.
Cell. Mol. Life Sci. 76,4829-4848 (2019)
PMID: 31363817
日本語総説/ Review in Japanese
- 植木将弘、*岩井一宏：「ユビキチン修飾異常による炎症病態〜HOIP変異症・HOIL-1変異症・SHARPIN変異症・OTULIN変異症」炎症と免疫 第27巻第5号363－370 (2019)
- *山野晃史：「損傷ミトコンドリアの選択的分解」生化学 第91巻第3号369－379 (2019)
- *山野晃史：「マイトファジー：損傷ミトコンドリアの選択的分解」DOJIN NEWS 第171号1－4 (2019)
- *内藤幹彦：「SNIPERによるプロテインノックダウン技術と創薬」Medical Science Digest 第45巻第4号 185－186 (2019)
- 堀江 透、*内藤幹彦：「質量分析法を用いたタンパク質の絶対定量と標的タンパク質分解誘導薬の開発」PHARM STAGE 第18巻1号1－6 (2019)
- *内藤幹彦：「タンパク質の発現を制御する技術と医薬品開発への応用」衛研報告 第137巻1－5 (2019）
- *伊藤拓水、半田 宏：「IMiDsの標的因子セレブロン」臨床血液 第60巻第9号1013－1019 (2019)
- 上田洋司、*土田邦博：「ユビキチン様タンパク質とエクソソームへのタンパク質輸送制御機構」生化学 第91巻第4号 514－518 (2019)
- 福田亮介、*沖米田司：「嚢胞性線維症における上皮細胞の水の輸送障害を理解する」消化器病学サイエンス 第3巻第2号18－22 (2019)
- *森戸大介：「もやもや病遺伝子の代謝制御機能」生化学 第91巻第6号815－819 (2019)
- *上田 実、高岡洋輔、齋藤大明：「有機化学者が計算化学者に助けてもらってリガンドー受容体間ドッキングによる分子設計に成功するまで」アンサンブル『実験と分子シミュレーションのインタープレイ』第21巻第3号196－203 (2019)
- *高岡洋輔：「植物ホルモン共受容体COI1-JAZのサブタイプ選択的リガンドの開発」化学と工業 第72巻第12号 (2019)
原著論文 / Publication
- Yamashita H, Tomoshige S, Nomura S, Ohgane K, Hashimoto Y, Ishikawa M.
Application of Protein Knockdown Strategy Targeting β-Sheet Structure to Multiple Disease-associated Polyglutamine Proteins.
Bioorg. Med. Chem. 28, 115175 (2020)
PMID: 31767406 - Lodochnikova OA, Chulakova DR, Gerasimova DP, Litvinov IA, Pradipta AR, Tanaka K, Kurbangalieva AR.
Stereochemical features of the crystallization of eight-membered 1,5-diazaheterocycles with chiral aminoindanol fragments at nitrogen atoms.
J. Struct. Chem. 61, 119-125 (2020) - Mimami S, Yokota N, Kawahara H.
BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
Biol. Open 9, bio047324 (2020)
PMID: 31911483 - Mishima Y, Brueckner L, Takahashi S, Kawakami T, Otani J, Shinohara A, Takeshita K, Garvilles RG, Watanabe M, Sakai N, Takeshima H, Nachtegael C, Nishiyama A, Nakanishi M, Arita K, Nakashima K, Hojo H, Suetake I.
Enhanced processivity of Dnmt1 by monoubiquitinated histone H3.
Genes Cells 25, 22-32 (2020)
PMID: 31680384 - Yamada M, Suzuki M, Noguchi T, Yokozawa T, Sekiguchi Y, Mutoh N, Toyama T, Hirata Y, Hwang GW, Matsuzawa A.
The antibiotic cefotaxime works as both an activator of Nrf2 and an inducer of HSP70 in mammalian cells.
BPB Rep. 3, 16-21 (2020) - Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y.
Stress- and ubiquitylation-dependent phase separation of the proteasome.
Nature 578, 296-300 (2020)
PMID: 32025036
プレスリリース
http://www.igakuken.or.jp/topics/2020/0205.html （都医学研）
https://www.amed.go.jp/news/release_20200206-02.html（AMED）
Highlighted in Cell Res
EurekAlert!
Faculty Opinions - Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.
Measurement of ATPase activity of valosin-containing protein/p97.
Bio-protocol 10, e3516 (2020) - Suvarna K, Honda K, Muroi M, Kondoh Y, Watanabe N, Osada H.
Identification of target protein for bio-active small molecule using photo-cross linked beads and MALDI-TOF mass spectrometry.
Bio-protocol 10, e3517 (2020) - Hirata Y, Inoue A, Suzuki S, Takahashi M, Matsui R, Kono N, Noguchi T, Matsuzawa A.
trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop.
Sci. Rep. 10, 2743 (2020)
PMID: 32066809
プレスリリース
https://www.tohoku.ac.jp/japanese/2020/02/press20200227-02-trance.html
https://www.tohoku.ac.jp/en/press/how_trans_fats_assist_cell_death.html - Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
Targeted protein degradation by chimeric compounds using hydrophobic E3 ligands and adamantane moiety.
Pharmaceuticals 13, E34 (2020)
PMID: 32106507 - Hashimoto S, Sugiyama T, Yamazaki R, Nobuta R,*Inada T.
Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells.
Sci. Rep. 10, 3422(2020)
PMID: 32099016 - Takahashi H, Ranjan A, Chen S, Suzuki H, Shibata M, Hirose T, Hirose H, Sasaki K, Abe R, Chen K, He Y, Zhang Y, Takigawa I, Tsukiyama T, Watanabe M, Fujii S, Iida M, Yamamoto J, Yamaguchi Y, Suzuki Y, Matsumoto M, Nakayama KI, Washburn M, Saraf A, Florens L, Sato S, Tomomori-Sato C, Conaway RC, Conaway JW, *Hatakeyama S.
The role of Mediator and Little Elongation Complex in transcription termination.
Nature Commun. 11, 1063 (2020)
PMID: 32102997 - Brazee PL, Morales-Nebreda L, Magnani ND, Garcia JG, Misharin AV, Ridge KM, Budinger GRS, Iwai K, Dada LA, Sznajder, JI.
Linear ubiquitin assembly complex regulates lung epithelial-driven responses during influenza infection.
J. Clin. Invest. 130, 1301-1314 (2020)
PMID: 31714898 - Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, Tamura N, Hatanaka A, Hirose S, Katayama H, Tani M, Kubo Y, Hamazaki J, Hamakubo T, Watanabe A, Murata S, Kobayashi A.
NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.
Mol. Cell. Biol. 40, e597-19 (2020)
PMID: 32123008 - Tateno S, Iida M, Fujii S, Suwa T, Katayama M, Tokuyama H, Yamamoto J, Ito T, Sakamoto S, Handa H, Yamaguchi Y.
Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide.
Sci. Rep. 10,4012 (2020)
PMID: 32132601 - Nishiyama A, Mulholland C, Bultmann S, Kori A, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H, Nakanishi M.
Two distinct modes of DNMT1 recruitment ensure the stable maintenance DNA methylation.
Nat. Commun. 11, 1222 (2020)
PMID: 32144273
プレスリリース
Faculty Opinions - Shibata N, Ohoka N, Tsuji G, Demizu Y, Akiyama T, Naito M.
Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.
Oncogene 39,3867-3878 (2020)
PMID: 32203161 - Arafiles JVV, Hirose H, Akishiba M, Tsuji S, Imanishi M, Futaki S.
Stimulating macropinocytosis for intracellular nucleic acid and protein delivery: a combined strategy with membrane-lytic peptides to facilitate endosomal escape.
Bioconjug. Chem. 31, 547-553 (2020)
PMID: 32017537 - Matsuo Y, Tesina P, Nakajima S, Mizuno M, Endo A, Buschauer R, Cheng J, Shounai O, Ikeuchi K, Iwasaki S, Saeki Y, Becker T, Beckmann R, Inada T.
RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
Nat. Stuct. Mol. Biol. 27, 323-332 (2020)
PMID: 32203490
プレスリリース
https://www.amed.go.jp/news/release_20200324-02.html（AMED）
https://www.tohoku.ac.jp/japanese/2020/03/press20200324-04-honnyaku.html（東北大学）
https://www.nikkei.com/article/DGKKZO57329880X20C20A3MY1000/（日経新聞） - Takaoka Y, Miyagawa S, Nakamura A, Egoshi S, Tsukiji S, Ueda M.
Hoechst-tagged Fluorescein Diacetate for the Fluorescence Imaging-based Assessment of Stomatal Dynamics in Arabidopsis thaliana.
Sci. Rep. 10, 5333 (2020)
PMID: 32210301 - Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunaga F, Takahashi H, Sawasaki T.
Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
Biochem. Biophys. Res. Commun. 524, 1-7 (2020)
PMID: 31898971 - Naito S, Fukushima T, Endo A, Denda K, Komada M.
Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.
FEBS Lett. 594,1778-1786 (2020)
PMID: 32162334 - Tsuchida M, Yokozawa T, Noguchi T, Shimada T, Yamada M, Sekiguchi Y, Hirata Y, Matsuzawa A.
Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin.
J. Toxicol. Sci. 45, 219-226 (2020)
PMID: 32238696 - Morihiro K, Okamoto A.
A highly constrained nucleic acid analog based on α-L-threosamine.
Nucleosides Nucleotides Nucleic Acids 39, 270-279 (2020)
PMID: 31530088 - Luong NC, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, Noguchi T, Matsuzawa A, Kumagai Y.
Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B.
J. Toxicol. Sci. 45, 349-363 (2020)
PMID: 32493877 - Wang L, Liu S, Xu J, Watanabe N, Di J, Wei W, Mayo KH, Li J, Li X.
A traditional Chinese Medicine, YXQN, Reduces Amyloid-induced Cytotoxicity by Inhibiting Aβ42 Aggregation and Fibril Formation.
Curr. Pharm. Des. 26, 780-789 (2020)
PMID: 32031066 - Chen J, Morihiro K, Fukui D, Guo L, Okamoto A.
Live-Cell Sensing of Telomerase Activity Using Hybridization-Sensitive Fluorescent Oligonucleotide Probes.
ChemBioChem 21, 1022-1027 (2020)
PMID: 31840916 - Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Commun. Biol. 3, 163 (2020)
PMID: 32246052 - Pradipta AR, Tanei T, Morimoto K, Shimazu K, Noguchi S, Tanaka K.
Emerging technologies for real-time intraoperative margin assessment in future breast-conserving surgery.
Adv. Sci. 7, 1901519 (2020)
PMID: 32382473 - Buschauer R, Matsuo Y (co-1st author), Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Gilmozzi A, Berninghausen O, Becker T, Coller J, Inada T, Beckmann R.
The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Science 368, 6448 (2020)
PMID: 32299921
プレスリリース - Sugawara E, Kato M, Kudo Y, Lee W, Hisada R, Fujieda Y, Oku K, Bohgaki T, Amengual O, Yasuda S, Onodera T, Hatakeyama S, Atsumi T.
Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts,
Autophagy 16, 946-955（2020）
PMID: 31486697 - Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, Iwasaki S.
Genome-wide survey of ribosome collision.
Cell Rep. 31,107610 (2020)
PMID: 32375038 - Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O.
The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis.
J. Am. Acad. Dermatol. 84,1103-1105 (2020)
PMID: 32439465 - Sako K, Futamura Y, Shimizu T, Matsui A, Hirano H, Kondoh Y, Muroi M, Aono H, Tanaka M, Honda K, Shimizu K, Kawatani M, Nakano T, Osada H, Noguchi K, Seki M.
Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.
Sci. Rep. 10, 8691 (2020)
PMID: 32457324 - Fuseya Y, Fujita H, Kim M, Ohtake F, Nishide A, Sasaki K, Saeki Y, Tanaka K, Takahashi R, Iwai K.
The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.
Nat. Cell Biol. 22, 663-673 (2020)
PMID: 32393887
プレスリリース - Tamemoto N, Akishiba M, Sakamoto K, Kawano K, Noguchi H, Futaki S.
Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules.
Mol. Pharm. 17, 2175-2185 (2020)
PMID: 32352304 - Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, Sawasaki T.
A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors.
Biomedicines 8, 152 (2020)
PMID: 32512835 - Sakamoto K, Akishiba M, Iwata T, Murata K, Mizuno S, Kawano K, Imanishi M, Sugiyama F, Futaki S.
Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules.
Angew. Chem. Int. Ed. Engl. 59, 19990-19998 (2020)
PMID: 32557993 - Nakatsu K, Yanase M, Hayashi G, Okamoto A.
Fmoc-Compatible and C-terminal-Sequence-Independent Peptide Alkyl Thioester Formation Using Cysteinylprolyl Imide.
Org. Lett. 22, 4670-4674 (2020)
PMID: 32484687 - Jo T, Nishikori M, Kogure Y, Arima H, Sasaki K, Sasaki Y, Nakagawa T, Iwai F, Momose S, Shiraishi A, Kiyonari H, Kagaya N, Onuki T, Shin-Ya K, Yoshida M, Kataoka K, Ogawa S, Iwai K, Takaori-Kondo A.
LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells.
Blood 136, 684–697 (2020)
PMID: 32325488
プレスリリース - Kori S, Jimenji T, Ekimoto T, Sato M, Kusano F, Oda T, Unoki M, Ikeguchi M, Arita K.
Serine 298 phosphorylation in linker 2 of UHRF1 regulates ligand-binding property of its tandem Tudor domain.
J. Mol. Biol. 432, 4064-4078 (2020)
PMID: 32428527 - Sugisawa E, Takayama Y, Takemura N, Kondo T, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, *Maruyama K.
RNA sensing by gut Piezo1 is essential for systematic serotonin synthesis.
Cell 182, 609-624 (2020)
PMID: 32640190 - Pradipta AR, Chang T C, Tanaka K.
Enantioselective synthesis of cyclic and linear diamines by iminocycloaddition.
Chirality 32, 1160-1168 (2020)
PMID: 32621328 - Yamaguchi S,Takagi R, Hosogane T, Ohashi Y, Sakai Y, Sakakihara S, Iino R, Tabata K, Noji H, Okamoto A.
Single cell array enclosed with a photodegradable hydrogel in microwells for image-based cell classification and selective photorelease of cells.
ACS Appl. Bio Mater. 3,9, 5887–5895 (2020) - Matsuura Y, Noguchi A, Yokota N, Kawahara H.
Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster.
J. Biochem. 168,477-489 (2020)
PMID: 32687160 - Suzuki G, Imura S, Hosokawa M, Katsumata R, Nonaka T, Hisanaga SI, Saeki Y, Hasegawa M.
α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome.
eLife 9, e56825 (2020)
PMID: 32697196 - Hashimoto E, Okuno S, Hirayama S, Arata Y, Goto T, Kosako H, Hamazaki J, Murata S.
Enhanced O-GlcNAcylation mediates cytoprotection under proteasome impairment by promoting proteasome turnover in cancer cells.
iScience 23,101299 (2020)
PMID: 32634741 - Yokoo H, Ohoka N, Naito M, Demizu Y.
Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.
Bioorg. Med. Chem. 28,115595 (2020)
PMID: 32631565 - Wang L, Liu S, Xu J, Watanabe N, Mayo KH, Li J, Li X.
Emodin inhibits aggregation of amyloid-β peptide 1-42 and improves cognitive deficits in Alzheimer's disease transgenic mice.
J. Neurochem. AOP (2020)
PMID: 32799401 - Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M.
Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.
ACS Chem. Biol. 15, 2195-2204 (2020)
PMID: 32584541 - Kawamura T, Futamura Y, Shang E, Muroi M, Janning P, Ueno M, Wilke J, Takeda S, Kondoh Y, Ziegler S, Watanabe N, Waldmann H, Osada H.
Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics.
Biosci. Biotech. Biochem. 84, 2484-2490 (2020)
PMID: 32867616 - Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, Matsuda N.
Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy.
J. Cell Biol. 219,e201912144 (2020)
PMID: 32556086 - Kondo T, Iwatani Y, Matsuoka K, Fujino T, Umemoto S, Yokomaku Y, Ishizaki K, Kito S, Sezaki T, Hayashi G, Murakami H.
Antibody-like proteins that capture and neutralize SARS-CoV-2.
Sci. Adv. 6, eabd3916 (2020)
PMID: 32948512 - Hirata Y, Nada Y, Yamada Y, Toyama T, Fukunaga K, Hwang GW, Noguchi T, *Matsuzawa A.
Elaidic acid potentiates extracellular ATP-induced apoptosis via the P2X7-ROS-ASK1-p38 axis in microglial cell lines.
Biol. Pharm. Bull. 43, 1562-1569 (2020)
PMID: 32999166 - Sophonnithiprasert T, Aruksakunwong O, Tashiro E, Kondoh Y, Muroi M, Osada H, Imoto M, Watanapokasin R.
Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress.
Heliyon 6, e05200 (2020)
PMID: 33102840 - Yamamoto J, Suwa T, Murase Y, Tateno S, Mizutome H, Asatsuma-Okumura T, Shimizu N, Kishi T, Momose S, Kizaki M, Ito T, Yamaguchi Y, Handa H.
ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells.
Nat. Chem. Biol. 16, 1208-1217 (2020)
PMID: 32958952 - Kowada T, Watanabe T, Amagai Y, Liu R, Yamada M,Takahashi H, Matsui T, Inaba K, Mizukami S.
Quantitative imaging of labile Zn2+ in the Golgi apparatus using a localizable small-molecule fluorescent probe
Cell Chem. Biol. 27, 1521–1531 (2020)
プレスリリース - Radwan MO, Ciftci HI, Ali TFS, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Fujita M, Otsuka M.
Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
Bioorg. Med. Chem. Lett. 30,127458 (2020)
PMID: 32755678 - Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.
A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.
Biosci. Biotechnol. Biochem. 84,2113-2120 (2020)
PMID: 32640867 - Ogata M, Hayashi G, Ichiu A, Okamoto A.
L-DNA-tagged fluorescence in situ hybridization for highly sensitive imaging of RNAs in single cells.
Org. Biomol. Chem. 18,8084-8088 (2020)
PMID: 33001106 - Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S.
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Commun. Biol. 3,592 (2020)
PMID: 33082525 - Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.
Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.
Environ. Pollut. 266, 115179 (2020)
PMID: 32717636 - Pan Y, Zhao Y, Kuang R, Liu H, Sun D, Mao T, Jiang K, Yang X, Watanabe N, Mayo KH, Lin Q, Li J.
Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion.
Mater. Sci. Eng., C 116, 111158 (2020)
PMID: 32806272 - Smirnov I, Sibgatullina R, Urano S, Tahara T, Ahmadi P, Watanabe Y, Pradipta AR, Kurbangalieva A, *Tanaka K.
A Strategy for Tumor Targeting by Higher-Order Glycan Pattern Recognition: Synthesis and In Vitro and In Vivo Properties of Glycoalbumins Conjugated with Four Different N-Glycan Molecules.
Small 16, 2004831 (2020)
PMID: 33079456 - Inoue S, Kaiserli E, Zhao X, Waksman T, Takemiya A, Okumura M, Takahashi H, Seki S, Shinozaki K, Endo Y, Sawasaki T, Kinoshita T, Zhang X, Christie J, Shimazaki K.
CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.
Plant J. 104, 679-692 (2020)
PMID: 32780529 - Arii J, Maeda F, Maruzuru Y, Koyanagi N, Kato A, Mori Y, Kawaguchi Y.
ESCRT-III controls nuclear envelope deformation induced by progerin.
Sci. Rep. 10, 18877 (2020)
PMID: 33139753 - Kudo T, Tominami K, Izumi S, Hayashi Y, Noguchi T, Matsuzawa A, Hong G, Nakai J.
Characterization of PC12 cell subclones with different sensitivities to programmedthermal stimulation.
Int. J. Mol. Sci., 21, 8356 (2020)
PMID: 33171774 - Matsuki Y, Matsuo Y, Nakano Y, Iwasaki S, Yoko H, Udagawa T, Li S, Saeki Y, Yoshihisa T, Tanaka K, Ingolia N, *Inada T.
Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome.
Sci. Rep. 10, 19669 (2020) - Hao F, Murphy KJ, Kujirai T, Kamo N, Kato J, Koyama M, Okamoto A, Hayashi G, Kurumizaka H, *Hayes JJ.
Acetylation-Modulated Communication between the H3 N-Terminal Tail Domain and the Intrinsically Disordered H1 C-Terminal Domain.
Nucleic Acids Res. 48, 11510–11520 (2020)
PMID: 33125082 - Oikawa D, Hatanaka N, Suzuki T, *Tokunaga F.
Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-mediated NF-kB Activation Pathway.
Front Immunol. 11, 601926 (2020)
PMID: 33329596 - Arii J, Fukui A, Shimanaka Y, Kono N, Arai H, Maruzuru Y, Koyanagi N, Kato A, Mori Y, Y Kawaguchi.
Role of phosphatidyl-ethanolamine biosynthesis in herpes simplex virus 1 infected cells on progeny virus morphogenesis in the cytoplasm and on viral pathogenicity in vivo.
J. Virol. 94, e01572-20 (2020)
PMID: 32999028 - Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück IM, Trummer C, Qin W, Bartoschek MD, Traube FR, Parsa E, Ugur E, Modic M, Acharya A, Stolz P, Ziegenhain C, Wierer M, Enard W, Carell T, Lamb DC, Takeda H, Nakanishi M, Bultmann S, *Leonhardt H.
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals.
Nat. Commun. 11, 5972 (2020)
PMID: 33235224 - Suzuki M, Asai Y, Kagi T, Noguchi T, Yamada M, Hirata Y, *Matsuzawa A.
TAK1 Mediates ROS Generation Triggered by the Specific Cephalosporins through Noncanonical Mechanisms.
Int. J. Mol. Sci., 21, 9497 (2020)
PMID: 33327477 - Muguruma K, Pradipta AR, Ode Y, Terashima K, Michiba H, Fujii M, *Tanaka K.
Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry.
Bioorg. Med. Chem. 28, 115831 (2020)
PMID: 33199202 - Hirano M, Saito C, Goto C, Yokoo H, Kawano R, *Misawa T, *Demizu Y.
Rational design of helix-stabilized antimicrobial peptide foldamers containing α,α-disubstituted amino acids or side-chain stapling.
ChemPlusChem 85,2731-2736 (2020)
PMID: 33369262
総説論文・書籍 / Review・Book
- *Itoh Y.
Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches.
Chem. Pharm. Bull. 68, 34-45 (2020)
PMID: 31902900 - Takaoka Y, Hayashi K, Suzuki K, Azizah IN, * Ueda M.
A Fluorescence Anisotropy-Based Comprehensive Method for the In Vitro Screening of COI1-JAZs Agonists and Antagonists.
Methods Mol. Biol. 2085, 145-160 (2020)
PMID: 31734923 - Ito T, *Handa H.
Molecular mechanisms of thalidomide and its derivatives.
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 96,189-203 (2020)
PMID: 32522938 - *Inada T.
Quality controls induced by aberrant translation.
Nucleic Acids Res. 48, 1084-1096 (2020)
PMID: 31950154 - *Matsuda N, Yamano K.
Two sides of a coin: physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin.
Neurosci. Res. 159. 16-24 (2020)
PMID: 32201358 - Fukuda R, *Okiyoneda T.
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitylation as a Novel Pharmaceutical Target for Cystic Fibrosis.
Pharmaceuticals(Basel) 13,75 (2020)
PMID: 32331485 - *Ishikawa M, Tomoshige S, Demizu Y, Naito M.
Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs.
Pharmaceuticals 13,74 (2020)
PMID: 32326273 - Asatsuma-Okumura T, *Ito T, Handa H.
Molecular Mechanisms of the Teratogenic Effects of Thalidomide.
Pharmaceuticals 96,189-203 (2020)
PMID: 32414180 - Oikawa D, Sato Y, Ito H, *Tokunaga F.
Linear ubiquitin code: Its writer, erasers, decoders, inhibitors, and implications in disorders.
Int. J. Mol. Sci. 21,E3381, 2020.
PMID: 32403254 - Tomoshige S, *Ishikawa M.
PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders.
Angew. Chem. Int. Ed. 3346-3354 (2020) - Nakatsu K, *Hayashi G, *Okamoto A.
Toolbox for chemically synthesized histone proteins.
Curr. Opin. Chem. Biol. 58, 10-19 (2020)
PMID: 32473259 - *Ohtake F.
Mass Spectrometry Technologies for Deciphering the Ubiquitin Code.
Trends Biochem. Sci. 45, 820-821 (2020)
PMID: 32423745 - Tsuchiya H, Endo A, *Saeki Y.
Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation.
Pharmaceuticals(Basel). 13, E128 (2020)
PMID: 32585960 - Futaki S, Arafiles JVV, Hirose H.
Peptide-assisted intracellular delivery of biomacromolecules.
Chem. Lett. 49, 1088–1094 (2020) - Yokoo H, *Misawa T, *Demizu Y.
De novo design of cell-penetrating foldamers.
Chem. Rec. 20,912-921 (2020)
PMID: 32463155 - *Yamano K, Youle RJ.
Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy.
Autophagy 16, 2105-2107 (2020)
PMID: 32892694 - *Watanabe N, Osada H.
Small molecule inhibitors of E3 ubiquitin ligases.
Drug Discovery Series No. 78
Protein-Protein Interaction Regulators (Roy, S. and Fu, H. eds.) Royal Society of Chemistry pp.109-123 (2020)
日本語総説/ Review in Japanese
- 村田茂穂、池浦隆真：「タンパク質分解装置プロテアソームと創薬」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1号11－15 (2020)
- *山野晃史：「不良ミトコンドリア分解を司るParkinとPINK1」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1号16－20 (2020)
- *佐伯 泰：「最先端プロテオミクス解析を用いたユビキチン研究」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56 巻第1号21－25 (2020)
- *沖米田司：「嚢胞性線維症のユビキチン創薬」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1 号31－35 (2020)
- *西山敦哉：「DNA維持メチル化機構を制御するユビキチンシグナル」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56 巻第1号36－40 (2020)
- 大岡伸通、*内藤幹彦：「新しい低分子薬の創薬モダリティPROTAC」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56 巻第1号41－45 (2020)
- *林 剛介：「タンパク質化学合成を活用した翻訳後修飾研究」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1号46－50 (2020)
- *高橋宏隆、山中聡士：「コムギ無細胞合成系による脱ユビキチン化酵素アレイの作製とDUB阻害剤開発への応用」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1号 51-55, (2020)
- 土屋 光、*佐伯 泰：「細胞内のユビキチン鎖長解析」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号14－19 (2020）
- *佐々木克博、*岩井一宏：「直鎖状ユビキチン鎖を生成するLUBACリガーゼの構造、機能、T細胞機能制御」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号20－27 (2020)
- *及川大輔、伊東秀文、徳永文稔：「直鎖状ユビキチン鎖の神経変性疾患への関与とLUBAC阻害剤の開発」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号 28－34 (2020)
- 濱崎 純、村田茂穂：「26Sプロテアソームによるユビキチン化タンパク質認識／分解機構」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号48－56 (2020)
- *大竹史明：「分岐型ユビキチン鎖とアセチル化ユビキチン」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号57－63 (2020)
- *高橋宏隆、山中聡士、徳永文稔、澤崎達也：「ヒト脱ユビキチン化酵素タンパク質アレイの開発とその応用例」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号64－74 (2020)
- 安田さや香、田中啓二、*佐伯 泰：「タンパク質のマルチバレント相互作用が駆動するLLPS」実験医学『構造生命科学からトランススケール・イメージングによる細胞動態学へ』第38巻第5号756－761 (2020)
- 伊藤拓水、山口雄輝、*半田 宏 「サリドマイド胎芽症の発症メカニズム」 サリドマイド胎芽症診療ガイド (2020)
- *水上 進：「生体分子反応を制御する」CSJ Current Review 36日本化学会編（化学同人，2020年），Chapter II-2章 「光による生体分子反応の制御」，p.51–56.
- 林 剛介、*岡本晃充：「エピジェネティック修飾の謎を解き明かす核酸およびタンパク質化学」CSJ Current Review 36「生体分子反応を制御する」(2020)
- 安田さや香、土屋 光、遠藤彬則、*佐伯 泰：カレントトピックス「液- 液相分離による核内タンパク質分解機構の発見」実験医学 第38巻第8号1358－1362 (2020)
- 福田亮介, *沖米田司：「嚢胞性線維症原因遺伝子産物CFTRの品質管理機構と機能制御」生化学 第92巻第2号179－188（2020）
- *川原裕之、南 雪也、宮内真帆、高橋俊樹：「ミニレヴュー：プレエンプティブ品質管理を介した膜タンパク質の選択的分解機構」生化学 第92巻第2号 1－6 (2020)
- *林 剛介、*岡本晃充：「タンパク質化学合成を加速するペプチドライゲーションの新技術」有機合成化学協会誌 78 巻第2号130－139 (2020)
- 高岡洋輔、*上田 実：「植物ホルモン・ジャスモン酸の多様な活性を制御するケミカルツールの合理的設計：植物の生長と防御を操作する化合物の創製」化学と生物 第58巻第4号200－201 (2020)
- *石川 稔、橋本祐一：「生細胞内の疾患関連タンパク質を減少させる低分子創薬手法の開発」有機合成化学協会誌 特集号「ニューモダリティ：有機合成化学の新しい可能性」第78巻5号229-239 (2020)
- 柴田識人、*内藤幹彦：「選択的なタンパク質分解誘導剤SNIPERsとPROTACs」臨床免疫・アレルギー科 第73 巻5号540-546 (2020)
- *高岡洋輔：「ジャスモン酸受容体のサブタイプ選択性を制御する化合物の創製研究」植物の生長調節, vol. 55, No. 1 (2020)
- *石川 稔：「疾患疾患原因タンパク質の寿命を短縮する分子の創製と医薬応用への課題」Drug Delivery System 第35巻3号 229 - 239 (2020)
- 平田祐介, *松沢 厚：「トランス脂肪酸と動脈硬化症」 食と医療 14号81-89 (2020)
- *西山敦哉、中西 真：「DNAメチル化複製機構」ニューサイエンス社 月刊「細胞」8月号 52(9), (2020)
- *福嶋俊明、川口紘平：「コラーゲンの細胞内輸送の分子機構 -脱ユビキチン化酵素USP8による輸送制御」FRAGRANCE JOURNAL 8月号 (2020)
- *内藤幹彦：「プロテインノックダウン技術の沿革と今後の展開」実験医学 第38巻14号2300−2304 (2020)
- 大岡伸通、内藤幹彦：「キメラ化合物PROTAC/SNIPERの作用機序と新たな開発の動向」実験医学 第38巻14号 2321-2325 (2020)
- 友重秀介、石川 稔：「神経変性疾患治療に向けたタンパク質分解アプローチ」実験医学 第38巻14号 2326 - 2330 (2020)
- 柴田識人、内藤幹彦：「脱ユビキチン化酵素阻害によるプロテインノックダウン」実験医学 第38巻14号 2337-2341 (2020)
- 伊藤拓水、 半田宏 :「サリドマイドの作用機序とセレブロンモジュレーター」実験医学 第38巻14号2310-2314 (2020)
- 大岡伸通、内藤幹彦：「標的タンパク質を分解する新しい低分子医薬モダリティ」実験医学 第38巻15号 2644-2650 (2020)
- 竹田 浩之，高橋 宏隆：「創薬を加速する評価系 〜プロテインアレイと AlphaScreen を基盤とした創薬標的探索技術〜」日本薬学会 SAR News No. 39: 8-16, (2020)
- *高岡 洋輔：「植物ホルモン受容体サブタイプ選択的ケミカルツールの開発〜PPIの組み合わせを制御する小分子〜」生命化学研究レター No. 61 (2020)
- 山野 晃史：「不良ミトコンドリア選択的オートファジーの分子基盤」BIO Clinica 第35巻12号62-67 (2020)
- 土屋 光、*佐伯 泰：「プロテアソームの液－液相分離」現代化学 増刊「相分離生物学の全貌」第46巻 p39-43 (2020)
- 石川 稔、友重 秀介：「標的タンパク質分解薬の動向ーPROTACsの先を見据えて」月刊化学 75巻70-71(2020)
- *林 剛介：「タンパク質化学合成を加速させるペプチド連結反応の化学 〜タンパク質を化学で創る時代を目指して〜」化学と工業 第73巻956－957 (2020)
- *佐伯 泰、安田さや香、土屋 光：「ストレスとユビキチンに依存したプロテアソームの液－液相分離」生化学 第92巻第6号822－826 (2020）
原著論文 / Publication
- Suzuki K, *Takaoka Y, Ueda M.
Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor.
RSC. Chem. Biol.2, 499-502 (2021)
PMID: 34458795 - Udagawa T, Seki M, Okuyama T, Adachi S, Natsume T, Noguchi T, Matsuzawa A, *Inada T.
Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival.
Cell Rep. 34, 108599 (2021)
PMID: 33406423
プレスリリース - Noguchi T, Sekiguchi Y, Kudoh Y, Naganuma R, Kagi T, Nishidate A, Maeda K, Ishi C, Toyama T, Hirata Y, Hwang GW, *Matsuzawa A.
Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms.
Cell Death Dis. 12, 49 (2021)
PMID: 33414419
プレスリリース - *Watanabe M, *Arii J, Takeshima K, Fukui A, Shimojima M, Kozuka-Hata H, Oyama M, Minamitani T, Yasui T, Kubota Y, Takekawa M, Kosugi I, Maruzuru Y, Koyanagi N, Kato A, Mori Y, Kawaguchi Y.
Prohibitin-1 contributes to the cell-to-cell transmission of herpes simplex virus 1 via the MAPK/ERK signaling pathway.
J. Virol. 95, e01413-20 (* contributed equally) (2021)
PMID: 33177205 - Yokoo H,# Shibata N,# Naganuma M, Murakami Y, Ito T, *Aritake K, *Naito M, *Demizu Y.
Development of hematopoietic prostaglandin D synthase-degradation inducer.
ACS Med. Chem. Lett. 12,236-241 (2021)
PMID: 33603969 - Hirano M, Saito C, Yokoo H, Goto C, Kawano R, *Misawa T, *Demizu Y.
Structure-activity relationship analysis of Mag2-based peptide foldamers.
Molecules 26,444 (2021)
PMID: 33466998 - Nakabayashi O, Takahashi H, Moriwaki K, Komazawa-Sakon S, Ohtake-F, Murai Y, Koyahara Y, Saeki Y, Yoshida Y, Yamazaki S, Tokunaga F, Sawasaki T, *Nakano H.
MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL.
Commun. Biol. 4, 80 (2021)
PMID: 33469115 - Iida T, *Itoh Y, Takahashi Y, Yamashita Y, Kurohara T, Miyake Y, Oba M, Suzuki T.
Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders.
ChemMedChem 16, 1609-1618 (2021)
PMID: 33470543 - Wilke J, Kawamura T, Xu H, Brause A, Friese A, Metz M, Schepmann D, Wünsch B, Artacho-Cordón A, Nieto FR, Watanabe N, Osada H, Ziegler S, *Waldmann H.
Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.
Cell Chem. Biol. 28, 1-7 (2021)
PMID: 33567254 - Kojima W, *Yamano K, Kosako H, Imai K, Kikuchi R, Tanaka K, Matsuda N.
Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy.
Autophagy 17, 2011-2036 (2021)
PMID: 33499712
プレスリリース - Soma-Kaiho A, Akizuki Y, Igarashi K, Endo A, Kawase Y, Shoda T, Demizu Y, Naito M, Saeki Y, Tanaka K, *Ohtake F.
TRIP12 enhances small molecule-induced degradation of BRD4 through K29/K48 branched ubiquitin chains.
Mol. Cell. 81, 1411-1424.e7 (2021)
PMID: 33567268
プレスリリース - Takehara Y, Yashiroda H, Matsuo Y, Zhao X, Kamigaki A, Matsuzaki T, Kosako H, Inada T, *Murata S.
The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation.
iScience 24, 102145 (2021)
PMID: 33665564 - Dat NQ, Thuy LTT, Hieu VN, Hai H, Hoang DV, Hai NTT, Thuy TTV, Komiya T, Rombouts K, Phuong DM, Hanh NV, Hoang TH, Sato-Matsubara M, Oikawa D, Yoishizato K, Tokunaga F, Pinzani M, *Kawada M.
His-Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
Hepatology. 73, 2527-2545 (2021)
PMID: 33815386 - *Kitanosono T, Hisada T, Yamashita Y, Kobayashi S.
Hydrogen-Bonding-Assisted Cationic Aqua Palladium(II) Complex 3381538Enables Highly Efficient Asymmetric Reactions in Water.
Angew. Chem. Int. Ed. 60, 3407-3411 (2021)
PMID: 33124701 - Yamanaka S, Murai H, Saito D, Abe G, Tokunaga E, Iwasaki T, Takahashi H, Takeda H, Suzuki T, Shibata N, Tamura K, Sawasaki T.
Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neo-substrate PLZF.
EMBO journal. 40, e105375 (2021)
PMID: 33470442 - Imada T, Shimi T, Kaio A, Saeki Y, *Kimura H.
RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells.
Genes Cells 26, 298-312 (2021)
PMID: 33608942 - Arafiles JVV, Hirose H, Hirai Y, Kuriyama M, Sakyiamah MM, Nomura W, Sonomura K, Imanishi M, Otaka A, Tamamura H, *Futaki S.
Discovery of a macropinocytosis-inducing peptide potentiated by medium-mediated intramolecular disulfide formation.
Angew. Chem. Int. Ed. Engl. 60, 11928-11936 (2021)
PMID: 33629482 - Kowada T, Arai K, Yoshimura A, Matsui T, Kikuchi K, *Mizukami S.
Optical manipulation of subcellular protein translocation using a photoactivatable covalent labeling system.
Angew. Chem. Int. Ed. 60, 11378-11383 (2021)
PMID: 33644979 - Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, *Goto Y, *Yoshida M.
Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.
Nat. Chem. Biol. 17,335-343 (2021)
PMID: 33168978
プレスリリース - *Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling.
PLoS One. 16, e0248158 (2021)
PMID: 33662037 - Kondo T, Eguchi M, Kito S, Fujino T, Hayashi G, Murakami H.
cDNA TRAP display for rapid and stable in vitro selection of antibody-like proteins.
Chem. Commun. 57, 2416-2419 (2021)
PMID: 33554979 - Morihiro K, Ishinabe T, Takatsu M, Osumi H, Osawa T, *Okamoto A.
Floxuridine Oligomers Activated under Hypoxic Environment.
J. Am. Chem. Soc. 143, 3340–3347 (2021)
PMID: 33648338 - Kowada T, Watanabe T, Liu R, *Mizukami S.
Protocol for synthesis and use of a turn-on fluorescent probe for quantifying labile Zn2+ in the Golgi Apparatus in live cells.
STAR Protoc. 2, 100395 (2021) - Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, *Tokunaga F.
Crosstalk between NDP52 and LUBAC in innate immune responses, cell death, and xenophagy.
Front Immunol. 12, 635475 (2021)
PMID: 33815386 - Kamo N, Kujirai T, Kurumizaka H, Murakami H, *Hayashi G, *Okamoto A.
Organoruthenium-Catalyzed Chemical Protein Synthesis to Elucidate the Functions of Epigenetic Modifications on Heterochromatin Factors.
Chem. Sci. 12, 5926-5937 (2021) - Yoshimoto R, Chhipi-Shrestha JK, Schneider-Poetsch T, Furuno M, Maxwell Burroughs A, Noma S, Suzuki H, Hayashizaki Y, Mayeda A, Nakagawa S, Kaida D, Iwasaki S, *Yoshida M.
Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation.
Cell Chem. Biol. 28, 1356-1365 (2021)
PMID: 33784500
プレスリリース - Sakakibara I, Yanagihara Y, Himori K, Yamada T, Sakai H, Sawada Y, Takahashi H, Saeki N, Hirakawa H, Yokoyama A, Fukada S, Sawasaki T, Imai Y.
Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4.
iScience. 24, 102303 (2021)
PMID: 33870126 - Rodriguez Carvajal A, Grishkovskaya I, Gomez Diaz C, Vogel A, Sonn-Segev A, Kushwah MS, Schodl K, Deszcz L, Orban-Nemeth Z, Sakamoto S, Mechtler K, Kukura P, Clausen T, *Haselbach D, *Ikeda F.
The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains.
eLife 10, e60660 (2021)
PMID: 34142657 - Li Y, Okatsu K, Fukai S, *Sato Y.
Structural basis for specific recognition of K6-linked polyubiquitin chains by the TAB2 NZF domain.
Biophys J. 120, 3355-3362 (2021)
PMID: 34242591
プレスリリース - Ichikawa Y, Hiramatsu M, Mita Y, Makishima M, Matsumoto Y, Masumoto Y, Muranaka A, Uchiyama M, Hashimoto Y, *Ishikawa M.
meta-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discovery.
Org. Biomol. Chem. 19, 446-456 (2021)
PMID: 33331380 - Tsukumo Y,# Tsuji G,# Yokoo H, Shibata N, Ohoka N, Demizu Y, *Naito M.
Protocols for synthesis of SNIPERs and the methods to evaluate the anticancer effects.
Methods Mol. Biol. 2365, 331-347 (2021)
PMID: 34432253 - Morimoto D, Walinda E, Takashima S, Nishizawa M, Iwai K, Shirakawa M, *Sugase K.
Structural dynamic heterogeneity opolyubiquitin subunits affects phosphorylation susceptibility.
Biochemistry 60, 573-583 (2021)
PMID: 33616406 - *Pradipta A R, Ahmadi P, Terashima K, Muguruma K, Fujii M, Ichino T, Maeda S, *Tanaka K.
Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation.
Chem. Sci. 12, 5438-5449 (2021)
プレスリリース - Pradipta A R, *Tanaka K.
Application of acrolein imines to organic synthesis, biofunctional studies, and clinical practice.
Chem. Rec. 21, 646-662 (2021)
PMID: 33769681 - *Suzuki M, Suzuki T, Watanabe M, Hatakeyama S, Kimuura S, Nakazono A, Homma A, Nakamaru Y, Homma A.
Role of intracellular zinc in molecular and cellular function in allergic inflammatory diseases.
Allergol. Int. 70, 190-200 (2021)
PMID: 33127267 - Gomez Diaz C, Jonsson G, Schodl K, Deszcz L, Bestehorn A, Eislmayr K, Almagro J, Kavirayani A, Seida M, Fennell ML, Hagelkrueys A, Kovarik P, Penninger MJ, *Ikeda F.
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.
iScience.24, 103241(2021)
PMID: 34755089 - *Nakazono A, Nakamaru Y, Ramezanpour M, Kondo T, Watanabe M, Hatakeyama S, Kimura S, Honma A, Wormald PJ, Vreugde S, Suzuki M, Homma A
Fluticasone propionate suppresses Poly(I:C)-induced ACE2 in primary human nasal epithelial cells.
Front. Cell. Infect. Microbiol. 11, 655666 (2021)
PMID: 33981629 - *Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K,Tokunaga F.
Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
Inflamm Res. 70, 539-541 (2021)
PMID: 33811487 - Toyama T, Hoshi T, Noguchi T, Saito Y, Matsuzawa A, Naganuma A, *Hwang G W.
Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia.
Sci. Rep. 11, 9832 (2021)
PMID: 33972601 - Hirata Y, Takahashi M, Yamada Y, Matsui R, Inoue A, Ashida R, Noguchi T, *Matsuzawa A.
trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway.
Sci. Rep. 11, 10350 (2021)
PMID: 33990641
プレスリリース - Kumamoto S, *Nishiyama A, Chiba Y, Miyashita R, Konishi C, Azuma Y, *Nakanishi M.
HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation.
Nucleic Acids Research 49, 5003-5016 (2021)
PMID: 33872376 - Xu H,# Ohoka N,# Yokoo H, Nemoto K, Ohtsuki T, Matsufuji H, Naito M, Inoue T, *Tsuji G, *Demizu Y.
Development of agonist-based PROTACs targeting liver X receptor.
Front. Chem. 9, 674967 (2021)
PMID: 34124002 - Nakane K, *Sato S, Niwa T, Tsushima M, Tomoshige S, Taguchi H, Ishikawa M, Nakamura H.
Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen.
J. Am. Chem. Soc. 143, 7726-7731 (2021)
PMID: 33904715 - Shimada T, Kudoh Y, Noguchi T, Kagi T, Suzuki M, Tsuchida M, Komatsu H, Takahashi M, Hirata Y, *Matsuzawa A.
The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1.
Int. J. Mol. Sci. 22, 5796 (2021)
PMID: 34071450 - Inagaki H, *Miyamoto K, Ando N, Murakami K, Sugisawa K, Yumoto E, Teruya M, Uchida K, Nobuki K, Kaji T, Takaoka Y, Hojo Y, Shinya T, Galis I, Nozawa A, Sawasaki T, Nojiri H, Ueda M, Okada K.
Deciphering OPDA signaling components in the momilactone-producing moss Calohypnum plumiforme.
Front. Plant Sci. 12, Article 688565 (2021) (Invited Article)
PMID: 34135933 - Wang L, Liu S, Xu J, Watanabe N, Mayo KH, *Li J, *Li X.
Emodin inhibits aggregation of amyloid-β peptide 1-42 and improves cognitive deficits in Alzheimer's disease transgenic mice.
J. Neurochem. 157, 1992-2007 (2021)
PMID: 32799401 - Kamo N, *Hayashi G, *Okamoto A.
Silyl-Protected Propargyl Glycine for Multiple Labeling of Peptides by Chemoselective Silyl-Deprotection.
Tetrahedron Lett. 73, 153093 (2021) - Morimoto J, Miyamoto K, Ichikawa Y, Uchiyama M, Makishima M, Hashimoto Y, *Ishikawa M.
Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog.
Sci. Rep. 11, 12697 (2021)
PMID: 34135380 - Wilke J, Kawamura T, Xu H, Brause A, Friese A, Metz M, Schepmann D, Wünsch B, Artacho-Cordón A, Nieto FR, Watanabe N, Osada H, Ziegler S, *Waldmann H .
Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.
Cell Chem. Biol. 28, 848-854.e5 (2021)
PMID: 33567254 - *Yokoo H, Hirano M, Ohoka N, Misawa T, *Demizu Y.
Structure-activity relationship study of amphipathic antimicrobial peptides using helix-destabilizing sarcosine.
J. Pept. Sci. e3360, 1-6 (2021)
PMID: 34164880 - Nishiyama K, *Maekawa M (co-first), Nakagita T, Nakayama J, Kiyoi T, Chosei M, Murakami A, Kamei Y, Takeda H, Takada Y, *Higashiyama S.
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.
Life Sci. Alliance.4, e202101095 (2021)
PMID: 34187934 - Saito R, Hayashi K, Nomoto H, Nakayama M, Takaoka Y, Saito H, Yamagami S, Muto T, *Ueda M.
Extended JAZ degron sequence for plant hormone binding in jasmonate co-receptor of tomato SlCOI1-SlJAZ.
Sci. Rep. 11, 13612 (2021)
PMID: 34193940 - Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y.
CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells.
J Biol. Chem. 297, 100803 (2021)
PMID: 34022224 - Takayama KI, Honma T, Suzuki T, Kondoh Y, Osada H, Suzuki Y, Yoshida M, Inoue S.
Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth.
Cancer Res. 81, 3495-3508 (2021)
PMID: 33975881 - Yoshida Y, Asahina M, Murakami A, Kawawaki J, Yoshida M, Fujinawa R, Iwai K, Tozawa R, Matsuda N, Tanaka K and Suzuki T.
Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.
Proc. Natl. Acad. Sci. USA 118, e2102902118 (2021)
PMID: 34215698 - *Beziat V, Rapaport F, Hu J, Titeux M, Bonnet des Claustres M, Bourgey M, Griffin H, Bandet E, Ma CS, Sherkat R, Rokni-Zadeh H, Louis DM, Changi-Ashtiani M, Delmonte OM, Fukushima T, Habib T, Guennoun A, Khan T, Bender N, Rahman M, About F, Yang R, Rao G, Rouzaud C, Li J, Shearer D, Balogh K, Al Ali F, Ata M, Dabiri S, Momenilandi M, Nammour J, Alyanakian MA, Leruez-Ville M, Guenat D, Materna M, Marcot L, Vladikine N, Soret C, Vahidnezhad H, Youssefian L, Saeidian AH, Uitto J, Catherinot E, Navabi SS, Zarhrate M, Woodley DT, Jeljeli M, Abraham T, Belkaya S, Lorenzo L, Rosain J, Bayat M, Lanternier F, Lortholary O, Zakavi F, Gros P, Orth G, Abel L, Pretet JL, Fraitag S, Jouanguy E, Davis MM, Tangye SG, Notarangelo LD, Marr N, Waterboer T, Langlais D, Doorbar J, Hovnanian A, Christensen N, Bossuyt X, Shahrooei M, *Casanova JL.
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
Cell 184, 3812-3828 (2021)
PMID: 34214472 - Koyama K, Hayashi G, Ueda H, Ota S, Nagae G, Aburatani H, *Okamoto A.
Base-Resolution Analysis of 5-Hydroxymethylcytidine by Selective Oxidation and Reverse Transcription Arrest.
Org. Biomol. Chem. 19, 6478-6486 (2021)
PMID: 34241617 - Ishikawa R, Yasuda M, Sasaki S, Ma Y, Nagasawa K, *Tera M.
Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease.
Chem. Commun. 57, 7236-7239 (2021)
PMID: 34263271 - Walinda E, Morimoto D, Sorada T, Iwai K, Sugase K.
Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures.
Protein Expr. Purif. 187,105953 (2021)
PMID: 34390872 - Obara S, Nakane K, Fujimura C, Tomoshige S, Ishikawa M, *Sato S.
Functionalization of Human Serum Albumin by Tyrosine Click.
Int. J. Mol. Sci. 22, 8676-8676 (2021)
PMID: 34445381 - Yokoo H,# Ohoka N,# Takyo M, Ito T, Tsuchiya K, Kurohara T, Fukuhara K, Inoue T, Naito M, *Demizu Y.
Peptide stapling improves the sustainability of a peptide-based chimeric molecule that induces targeted protein degradation.
Int. J. Mol. Sci.22, 8772 (2021)
PMID: 34445478 - Yoshida K, Kondoh Y, Nakano T, Bolortuya B, Kawabata S, Iwahashi F, Nagano E, Osada H.
New abscisic acid derivatives revealed adequate regulation of stomatal, transcriptional, and developmental responses to conquer drought.
ACS Chem. Biol. 16, 1566-1575 (2021)
PMID: 34379974 - Kondo T, Eguchi M, Tsuzuki N, Murata N, Fujino T, Hayashi G, *Murakami H.
Construction of a Highly Diverse mRNA Library for In Vitro Selection of Monobodies.
bio-protocol 11, e4125 (2021)
PMID: 34541043 - Yamamoto K, Goyama S, Asada S, Fujino T, Yonezawa T, Sato N, Takeda R, Tsuchiya A, Fukuyama T, Tanaka Y, Yokoyama A, Toya H, Kon A, Nannya Y, Onoguchi-Mizutani R, Nakagawa S, Hirose T, Ogawa S, Akimitsu N, *Kitamura T.
A histone modifier ASXL1 interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.
Cell Rep. 36, 109576 (2021)
PMID: 34433054
プレスリリース - Anzai H, *Terai T, Wakabayashi-Nakao K, Noguchi T, Kumachi S, Tsuchiya M, *Nemoto N.
Interleukin-17A Peptide Aptamers with an Unexpected Binding Moiety Selected by cDNA Display under Heterogenous Conditions.
ACS Med. Chem. Lett. 12, 1427-1434 (2021)
PMID: 34531951 - Iwata T, Hirose H, Sakamoto K, Hirai Y, Arafiles JVV, Akishiba M, Imanishi M, *Futaki S.
Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides.
Angew. Chem. Int. Ed. Engl. 60, 19804-19812 (2021)
PMID: 34114295 - Morihiro K, Moriyama Y, Nemoto Y, Osumi H, *Okamoto A.
anti-syn Unnatural Base Pair Enables Alphabet-Expanded DNA Self-Assembly.
J. Am. Chem. Soc. 143, 14207-14217 (2021)
PMID: 34450012 - *Pradipta A R, *Tanaka K.
Biofunctional chemistry and reactivity of biogenic acrolein for cancer diagnosis and therapy.
Chem. Commun. 57, 9798-9806 (2021)
PMID: 34581321 - Tokuchi K, Kitamura S, Maeda T, Watanabe M, Hatakeyama S, Kano S, Tanaka S, Ujiie H, *Yanagi T.
Loss of FAM83H promotes cell migration and invasion in cutaneous squamous cell carcinoma via impaired keratin distribution.
J. Dermatol. Sci. 104, 112-121 (2021)
PMID: 34657752 - Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A.
Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.
Cancer Sci. 112, 4303-4316 (2021)
PMID: 34289205 - Tan FHP, Ting ACJ, Leow BG, Najimudin N, Watanabe N, *Azzam G.
Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer’s disease.
J. Ethnopharmacology 279, 114389 (2021)
PMID: 34217797 - Yokoo H, *Shibata N, Endo A, Ito T, Yanase Y, Murakami Y, Fujii K, Hamamura K, Saeki Y, *Naito M, *Aritake K, *Demizu Y.
Discovery of a highly potent and selective PROTAC targeting hematopoietic prostaglandin D synthase via in silico design.
J. Med. Chem. 64, 15868-15882 (2021)
PMID: 34652145 - Kakihara K, Asamizu K, Moritsugu K, Kubo M, Kitaguchi T, Endo A, Kidera A, Ikeguchi M, Kato A, *Komada M, *Fukushima T
Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain.
Commun. Biol. 4, 1272 (2021)
PMID: 34750505 - *Kanazawa N, Hemmi H, Kinjo N, Ohnishi H, Hamazaki J, Mishima H, Kinoshita A, Mizushima T, Hamada S, Hamada K, Kawamoto N, Kadowaki S, Honda Y, Izawa K, Nishikomori R, Tsumura M, Yamashita Y, Tamura S, Orimo T, Ozasa T, Kato T, Sasaki I, Fukuda-Ohta Y, Wakaki-Nishiyama N, Inaba Y, Kunimoto K, Okada S, Taketani T, Nakanishi K, Murata S, Yoshiura K, *Kaisho T.
Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency.
Nature Comm.12, 6819 (2021)
PMID: 34819510 - Sakamoto T, Fukui Y, Kondoh Y, Honda K, Shimizu T, Hara T, Hayashi T, Saitoh Y, Murakami Y, Inoue J, Kaneko S, Osada H, Seiki M.
Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock.
Commun. Biol. 4, 1165 (2021)
PMID: 34621018 - Kwong MMY, Lee JW, Samian MR, Wahab H, Watanabe N, Ong EBB.
Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span.
Cells 10, 2718 (2021)
PMID: 34685698 - Tan FHP, Hadri NAB, Najimudin N, Watanabe N, *Azzam G.
Ethyl caffeate ameliorated Aβ42-associated toxicity in PC12 cells and Drosophila melanogaster.
Geriatr. Gerontol. Int. 21, 1125-1130 (2021)
PMID: 34699118 - Moon JY, Adams E, Miyazaki T, Kondoh Y, Muroi M, Watanabe N, Osada H, Shin R.
Cesium tolerance is enhanced by a chemical which binds to BETA- GLUCOSIDASE 23 in Arabidopsis thaliana.
Sci. Rep. 11, 21109 (2021)
PMID: 34702872 - Shimizu N, Asatuma-Okumura T, Yamamoto J, Yamaguchi Y, *Handa H，*Ito T.
PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates.
Commun Biol. 4, 1277 (2021)
PMID: 34764413 - Yoshida J, Ohishi T, Abe H, Ohba S, Inoue H, Usami I, Amemiya M, Oriez R, Sakashita C, Dan S, Sugawara M, Kawaguchi T, Ueno J, Asano Y, Ikeda A, Takamatsu M, Amori G, Kondoh Y, Honda K, Osada H, Noda T, Watanabe T, Shimizu T, Shibasaki M, Kawad M.
Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment.
iScience 24, 103497 (2021)
PMID: 34934919 - Kuriyama Y, *Shimizu A, Kanai S, Oikawa D, Motegi SI, Tokunaga F, Ishikawa O.
Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease.
Sci Rep. 11, 23146 (2021)
PMID: 34848794 - Sasaki S, Kitamura J, Endo H, Shiraishi A, Ikebukuro K, Mizutani T, *Tera M.
Identification of G-quadruplex sequences in severe acute respiratory syndrome coronavirus 2.
Translat Regulat Sci.3,89-92 (2021) - Kori S, Shibahashi Y, Ekimoto T, Nishiyama A, Yoshimi S, Yamaguchi K, Nagatoishi S, Ohta M, Tsumoto K, Nakanishi M, Defossez PA, Ikeguchi M, *Arita K.
Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.
Bioorg Med. Chem. 52, 116500 (2021)
PMID: 34801826 - Lee JW, Ong TG, Samian MR, Teh AH, Watanabe N, Osada H, Ong EBB.
Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisoae.
Sci. Rep. 11, 24148 (2021)
PMID: 34921163
総説論文・書籍 / Review・Book
- Takeuchi J, Fukui K, Seto Y, *Takaoka Y, *Okamoto M.
Ligand-receptor interactions in plant hormone signaling.
The Plant Journal, 106, 290 (2021) - Naito M, Murata S.
Gluing proteins for targeted degradation.
Cancer Cell 39, 19-21 (2021)
PMID: 33434510 - Ohnishi M, Yamano K, *Sato M, *Matsuda N, *Okamoto K.
Molecular mechanisms and physiological functions of mitophagy.
EMBO J 40, e104705 (2021)
PMID: 33438778 - Iwai K.
Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death. ~Discovery-In-Context Review ~
FEBS J. 288, 1060-1069 (2021)
PMID: 32627388 - Yokoo H, Hirano M, Misawa T *Demizu Y.
Helical antimicrobial peptide foldamers containing non-proteinogenic amino acids.
ChemMedChem 16, 1226-1233 (2021)
PMID: 33565721 - Tomoshige S, *Ishikawa M.
PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders.
Angew. Chem. Int. Ed. 60, 3346-3354 (2021)
PMID: 32410219 - Iwai K.
LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling.
Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 97, 120-133 (2021)
PMID: 33692228 - Sato T, Ito T, *Handa H.
Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.
Front. Cell Dev. Biol. 9, 629326 (2021)
PMID: 33777938 - Sakakibara I, Yanagihara Y, Himori K, Yamada T, Sakai H, Sawada Y, Takahashi H, Saeki N, Hirakawa H, Yokoyama A, Fukada S, Sawasaki T, *Imai Y.
Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4.
iScience. 24, 102303 (2021)
PMID: 33870126 - Futaki S.
Functional Peptides That Target Biomembranes: Design and Modes of Action.
Chem. Pharm. Bull. 69, 601-607 (2021)
PMID: 34193708 - *Nishiyama A, *Nakanishi M.
Navigating the DNA methylation landscape of cancer.
Trends Genet. 37, 1012-1027 (2021)
PMID: 34120771 - Kagi T, Noguchi T, *Matsuzawa A.
Mechanisms of gefitinib-induced interstitial pneumonitis: why and how the TKI perturbs innate immune systems?
Oncotarget 12, 1321-1322 (2021)
PMID: 34194630 - *Tomoshige S, Ishikawa M.
In Vivo Synthetic Chemistry of Proteolysis Targeting Chimeras (PROTACs)
Bioorg. Med. Chem. 41, 116221 (2021)
PMID: 34034148 - Ito T, Yamaguchi Y, *Handa H.
Exploiting ubiquitin ligase Cereblon as a target for small-molecule compounds in medicine and chemical biology.
Cell Chem. Biol. 28, 987-999 (2021)
PMID: 34033753 - Utsugi Y, *Miyamae Y.
Strategies for Post-Translational Control of Protein Expression and their Applications.
Appl. Sci. 11, 8300 (2021) - *Yamano K, Kojima W.
Molecular functions of autophagy adaptors upon ubiquitin-driven mitophagy.
Biochim Biophys Acta Gen Subj 1865, 129972 (2021)
PMID: 34332032 - *Schneider-Poetsch T, Chhipi-Shrestha JK, Yoshida M.
Splicing modulators: on the way from nature to clinic.
J Antibiot. 74, 603-616 (2021)
PMID: 34345042 - Morishita R, Takahashi H, Sawasaki T.
Cell-free based protein array technology. In: Suzuki T, Poignard C, Chaplain M, Quaranta V (eds).
Methods of Mathematical Oncology, Fusion of Mathematics and Biology, Osaka, Japan.
Springer Proceedings in Mathematics & Statistics. 255-265, (2021) - Fuseya Y, Iwai K.
Biochemistry, Pathophysiology, and Regulation of Linear Ubiquitination: Intricate Regulation by Coordinated Functions of the Associated Ligase and Deubiquitinase.
Cells 10, 2706 (2021)
PMID: 34685685
日本語総説/ Review in Japanese
- 内藤幹彦、小松弘嗣：「分子間相互作用を基盤とするユビキチン・プロテアソーム創薬」日本薬理学雑誌 『ユビキチンプロテアソーム創薬の新展開』 第156巻1号9-12 (2021)
- 村田茂穂：「新モダリティーとしてのProtein Degrader」月刊「細胞」『Targeted Protein Degradation』 第53巻3号134-135 (2021)
- *内藤幹彦：「ハイブリッド化合物（PROTAC, SNIPER）」月刊「細胞」 『Targeted Protein Degradation』 第53巻3号136-139 (2021)
- *伊藤拓水、朝妻知子、半田宏：「Molecular Glue Degrader」月刊「細胞」『Targeted Protein Degradation』 第53巻3号140-143 (2021)
- 横尾英知、*出水庸介：「Targeted Protein Degrader合成の戦略」月刊「細胞」『Targeted Protein Degradation』 第53巻3号148-151 (2021)
- 渡部昌、*畠山鎮次：「TRIMファミリータンパク質と標的タンパク質分解」月刊「細胞」『Targeted Protein Degradation』 第53巻3号28-3 (2021)
- *川原裕之：「プレエンプティブ品質管理を介した不良タンパク質のサーベイランスとその意義」月刊「細胞」『Targeted Protein Degradation』第53巻3号179 - 181 (2021)
- 宇津木優樹、鈴木琢海、*宮前友策：「小分子化合物による細胞内タンパク質の分解制御技術」バイオサイエンスとインダストリー 第79巻3号200-204（2021）
- 横尾英知、*出水庸介： 「TPD創薬への有機化学的アプローチ」 ファルマシア『モダリティ多様化を支援する創薬基盤技術』 第57巻第7号615-619 (2021)
- *石川稔：「医薬リード化合物の体内動態改善法 –水溶性・脂溶性のアウフヘーベン– 」ファルマシア 『モダリティ多様化を支援する創薬基盤技術』第57巻7号620-624（2021）
- *石川稔：「標的タンパク質を分解する低分⼦ 〜疾患関連タンパク質をゴミ箱へ〜」 生命化学研究レター 第62巻4号 9-14 (2021)
- *今井浩孝，松沢厚：「環境・衛生部会シンポジウム −食品栄養素ストレスによる疾患とその予防戦略−」YAKUGAKU ZASSHI 日本薬学会, 141, 667-668 (2021)
- *松沢厚：「トランス脂肪酸による毒性発現の分子メカニズムと関連疾患の発症予防」 YAKUGAKU ZASSHI 日本薬学会, 141, 675-679 (2021)
- 戸田 有亮、岩井 一宏：「ユビキチン修飾異常による炎症病態」血液内科 第82巻第5号 666-672 (2021)
- 伏屋 康寛、 岩井 一宏：「免疫応答と細胞死を制御する直鎖状ユビキチン鎖の生成調節機構の解明とその応用」臨床免疫・アレルギー科 第75巻第6号 730-735 (2021)
- *佐伯 泰：「ユビキチン修飾と相分離」実験医学『相分離メカニズムと疾患』第39巻第10号1620－1627 (2021)
- *佐伯 泰、遠藤彬則、大竹史明：「ユビキチンコード研究の最前線」MEDCHEM NEWS 第31巻第3号 136-142 (2021)
- 二木史朗，広瀬久昭：「マクロピノサイトーシスを活用した細胞内送達の可能性」 生化学 93巻1号 137‒140 (2021)
- 近藤太志、梅本駿、藤野公茂、林剛介、*村上裕：「新型コロナウイルスに対する迅速な人工抗体創製」 創薬研究者がこれだけは知っておきたい最新のウイルス学 第10章 第7節（2021）
- *池田史代：「ユビキチン分子によるコーディングシステム」 生化学 第93巻第6号797-805（2021）
原著論文 / Publication
- Takaoka Y, Suzuki K, Nozawa A, Takahashi H, Sawasaki T, Ueda M.
Protein-protein interactions between jasmonate-related master regulator MYC and transcriptional mediator MED25 depend on a short binding domain.
J Biol Chem. 298, 101504 (2022)
PMID: 34929168 - #Ohoka N, #Yokoo H, Okuhira K, Demizu Y, *Naito M.
Molecular design, synthesis and evaluation of SNIPER(ER) that induces targeted protein degradation of ERa.
Methods Mol. Biol. 2418, 363-382 (2022)
PMID: 35119675 - Kagi T, Naganuma R, Inoue A, Noguchi T, Hamano S, Sekiguchi Y, Hwang G W, Hirata Y, *Matsuzawa A.
The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages.
J. Antibiot. 75, 29-39 (2022)
PMID: 34824374 - *Pradipta A R, Michiba H, Kubo A, Fujii M, Tanei T, Morimoto K, Shimazu K, *Tanaka K.
The secon-generation click-to-sense probe for intraoperative diagnosis of breast cancer tissues based on acrolein targeting.
Bull. Chem. Soc. Jpn. (2022) - Mizumoto Y, Sakamoto R, Nagata A, Sakane S, Kittaka A, Odagi M, Tera M, Nagasawa K.
Synthesis of C2-Alkoxy-Substituted 19-Nor Vitamin D 3 Derivatives: Stereoselectivity and Biological Activity
Biomolecules. 12, 69 (2022)
PMID: 35053217 - Yamanaka S, Horiuchi Y, Matsuoka S, Kido K, Nishino K, Maeno M, Shibata N, Kosako H, *Sawasaki T.
A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues.
Nature Communications 13, 183 (2022)
PMID: 35013300
プレスリリース - Naganuma M, *Ohoka N, Tsuji G, Tsujimura H, Matsuno K, Inoue T, Naito M, *Demizu Y.
Development of chimeric molecules that degrade the estrogen receptor using decoy oligonucleotide ligands.
ACS Med. Chem. Lett. 13, 134-139 (2022)
PMID: 35059133 - Taniguchi S, Ito Y, Kiritani H, Maruo A, Sakai R, Ono Y, Fukuda R, *Okiyoneda T.
The ubiquitin ligase RNF34 participates in the peripheral quality control of CFTR.
Front. Mol. Biosci. 9, 840649 (2022)
PMID: 35355508 - Huang Y, Yokoe H, Kaiho-Soma A, Takahashi K, Hirasawa Y, Morita H, *Ohtake F, *Kanoh N.
Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation.
Bioconjug Chem. 33, 142-151 (2022)
PMID: 34878263 - Nitschke S, Sullivan MA, Mitra S, Marchioni CR, Lee JPY, Smith BH, Ahonen S, Wu J, Chown EE, Wang P, Petković S, Zhao X, DiGiovanni LF, Perri AM, Israelian L, Grossman TR, Kordasiewicz H, Vilaplana F, Iwai K, Nitschke F, Minassian BA.
Glycogen synthase downregulation rescues the amylopectinosis of murine RBCK1 deficiency.
Brain, awac017 (2022)
PMID: 35084461 - Hasegawa Y, Reyes TH, Uemura T, Baral A, Fujimaki A, Luo Y, Morita Y, Saeki Y, Maekawa S, Yasuda S, Mukuta K, Fukao Y, Tanaka K, Nakano A, Takagi J, Bhalerao RP, Yamaguchi J, Sato T.
The TGN/EE SNARE protein SYP61 and the ubiquitin ligase ATL31 cooperatively regulate plant responses to carbon/nitrogen conditions in Arabidopsis.
Plant Cell. 34, 1354-1374 (2022)
PMID: 35089338 - Zou X, Liu Y, Di J, Wei W, Watanabe N, Li J, Li X.
ZMIZ2 promotes the development of triple-receptor negative breast cancer.
Cancer Cell Int. 22, 52 (2022)
PMID: 35101047 - Tsunoda T, Riku M, Yamada N, Tsuchiya H, Tomita T, Suzuki M, Kizuki M, Inoko A, Ito H, Murotani K, Murakami H, Saeki Y, *Kasai K.
ENTREP/FAM189A2 downregulated in breast cancer encodes a new activator for ITCH ubiquitin ligase.
EMBO Rep. 23, e51182 (2022)
PMID: 34927784 - Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.
Identification of a small molecule that enhances ferroptosis via inhibition of FSP1.
ACS Chem. Biol. 17, 483-491 (2022)
PMID: 35128925
プレスリリース - Shioya R, Yomada K, Kido K, Takahashi H, Nozawa A, Miyakawa T, Kosako H, Sawasaki T.
A simple method for labeling proteins and antibodies with biotin using the proximity biotinylation enzyme TurboID.
Biochem Biophys Res Commun. 592, 54-59 (2022)
PMID: 35030423 - Hirai K, Yamashita H,*Tomoshige S, Mishima Y, Niwa T, Ohgane K, Ishii M, Kanamitsu K, Ikemi Y, Nakagawa S, Taguchi H, Sato S, Hashimoto Y,*Ishikawa M.
Conversion of a PROTAC mutant huntingtin degrader into small-molecule hydrophobic tags focusing on drug-like properties.
ACS Med. Chem. Lett. 13, 396-402 (2022)
PMID: 35300080 - Kodama Y, Takeo S, Fujimoto J, Sato K, Mase N, *Narumi T.
Synthesis and Structural Characterization of β-Turn Mimics Containing (Z)-Chloroalkene Dipeptide Isosteres.
J. Org. Chem. 87, 2167-2177 (2022)
PMID: 35179382 - Chhipi-Shrestha JK, Schneider-Poetsch T, Suzuki T, Mito M, Khan K, Dohmae N, *Iwasaki S, *Yoshida M.
Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns.
Cell Chem. Biol. 29, 259-275 (2022)
PMID: 34520743
プレスリリース - Wei W, Pathak J L, LIU X, Mao T, Watanabe N, Li X, Zhang M, Li J.
Apigenin, a single active component of herbal extract, alleviates xerostomia via ERα-mediated upregulation of AQP5 activation.
Front. Pharmacol. 13, 818116 (2022)
PMID: 35264956 - Shinkawa Y, Imami K, Fuseya Y, Sasaki K, Ohmura K, Ishihama Y, Morinobu A, Iwai K.
ABIN1 is a signal-induced autophagy receptor that attenuates NF-kB activation by recognizing linear ubiquitin chains.
FEBS Lett. 596, 1147-1164 (2022)
PMID: 35213742 - Shibata N, Cho N, Koyama H, Naito M.
Development of a degrader against oncogenic fusion protein FGFR3-TACC3.
Bioorg Med Chem Lett 60, 128584 (2022)
PMID: 35085722 - Sasaki K, Suzuki M, Sonoda T, Schneider-Poetsch T, Ito A, Takagi M, Fujishiro S, Sohtome Y, Dodo K, Umehara T, Aburatani H, Shin-ya K, Nakao Y, Sodeoka M, *Yoshida M.
Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells.
Cell Chem. Biol. 29, 1153-1161 (2022)
PMID: 35728598
プレスリリース - Terai T, *Campbell R E.
Barcodes, co-cultures, and deep learning take genetically encoded biosensor multiplexing to the nth degree.
Mol. Cell. 82, 239–240 (2022)
PMID: 35063093 - Kondo T, Matsuoka K, Umemoto S, Fujino T, Hayashi G, Iwatani Y, *Murakami H.
Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern.
Life Sci. Alliance 5, e202101322 (2022)
PMID: 35256514 - Yu S, Wang L, Che D, Zhang M, Li M, Naito M, Xin W, Zhou L.
Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling.
J Exp Clin Cancer Res 41, 88 (2022)
PMID: 35260193 - Wood MJ, Marshall JN, Hartley VL, Liu TC, Iwai K, Stappenbeck TS, MacDuff DA.
HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine
Mucosal Immunol. 15, 642-655 (2022)
PMID: 35534698 - Nakane K, Niwa T, Tsushima M, Tomoshige S, Taguchi H, Nakamura H, Ishikawa M, Sato S.
BODIPY Catalyzes Proximity‐Dependent Histidine Labelling.
ChemCatChem 14, e202200077 (2022) - Hoang DV, Thuy LTT, Hai H, Hieu VN, Kimura K, Oikawa D, Ikura Y, Dat NQ, Hoang TH, Sato-Matsubara M, Dong MP, Hanh NV, Uchida-Kobayashi S, Tokunaga F, Kubo S, Ohtani N, Yoshizato K, *Kawada N.
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species.
Oncogenesis. 11, 23 (2022)
PMID: 35504863 - Nakagawa Y, Arafiles JVV, Kawaguchi Y, Nakase I, Hirose H, Futaki S.
Stearylated Macropinocytosis-Inducing Peptides Facilitating the Cellular Uptake of Small Extracellular Vesicles.
Bioconjug. Chem. 33, 869-880 (2022)
PMID: 35506582 - Kato H, Nemoto K, Shimizu M, Abe A, Asai S, Ishihama N, Matsuoka S, Daimon T, Ojika M, Kawakita K, Onai K, Shirasu K, Yoshida M, Ishiura M, Takemoto D, Takano Y, Terauchi R.
Recognition of pathogen-derived sphingolipids in Arabidopsis.
Science. 376, 857-860 (2022)
PMID: 35587979
プレスリリース - Nakano N, Fukuda K, Tashiro E, Ishikawa H, Nagano W, Kawamoto R, Mori A, Watanabe M, Yamazaki R, Nakane T, Naito M, Okamoto I, *Itoh, S.
Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader.
J Biochem. 171, 631-640 (2022)
PMID: 35211741 - Hieu VN, Thuy LTT, Hai H, Dat NQ, Hoang DV, Hanh NV, Phuong DM, Hoang TH, Sawai H, Shiro Y, Sato-Matsubara M, Oikawa D, Tokunaga F, Yoshizato K, *Kawada N.
Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion.
Redox Biol. 52, 102286 (2022)
PMID: 35334247 - Watanabe A, Hama K, Watanabe K, Fujiwara Y, Yokoyama K, Murata S, *Takita R.
Controlled tetradeuteration of straight-chain fatty acids: synthesis, application, and insight into the metabolism of oxidized linoleic acid.
Angew Chem Int Ed Engl. e202202779 (2022)
PMID: 35411582 - Pan M, Zorbas C, Sugaya M, Ishiguro K, Kato M, Nishida M, Zhang H-F, Candeias M M, Okamoto A, Ishikawa T, Soga T, Aburatani H, Sakai J, Matsumura Y, Suzuki T, Proud C G, Lafontaine D L J, *Osawa T.
Glutamine Deficiency in Solid Tumor Cells Confers Resistance to Ribosomal RNA Synthesis Inhibitors.
Nat. Commun. 13, 3706 (2022)
PMID: 35764642 - *Tanahashi N, Komiyama M, Tanaka M, Yokobori Y, Murata S, Tanaka K.
The effect of nutrient deprivation on proteasome activity in 4-week-old mice and 24-week-old mice.
J Nutr Biochem 105, 108993 (2022)
PMID: 35331898 - #Xu H, #Kurohara T, Takano R, Yokoo H, Shibata N, Ohoka N, Inoue T, Naito M, *Demizu Y.
Development of rapid and facile solid-phase synthesis of PROTACs via a variety of binding styles.
ChemistryOpen. 11, e202200131 (2022)
PMID: 35822913 - Cho N, Kikuzato K, Futamura Y, Shimizu T, Hayase H, Kamisaka K, Takaya D, Yuki H, Honma T, Niikura M, Kobayashi F, *Watanabe N, Osada H, *Koyama H.
New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety.
Bioorg. Med. Chem. 66, 116830 (2022)
PMID: 35594648 - Chhipi-Shrestha JK, Yoshida M, Iwasaki S.
Filter trapping protocol to detect aggregated proteins in human cell lines.
STAR Protoc. 3, 101571 (2022)
PMID: 35880124 - Takada H, Tsuchiya K, *Demizu Y.
Helix-stabilized cell-penetrating peptides for delivery of antisense morpholino oligomers: Relationships among helicity, cellular uptake, and antisense activity.
Bioconjug. Chem. 33, 1311-1318 (2022)
PMID: 35737901 - Hara Y, *Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika, H, Tokunaga F, Uchida S.
LRBA is essential for urinary concentration and body water homeostasis.
Proc Natl Acad Sci U S A. 119, e2202125119 (2022)
PMID: 35862451 - Yamahira S, Misawa R, Kosaka T, Tan M, Izuta S, Yamashita H, Heike Y, Okamoto A, Nagamune T, *Yamaguchi S.
Photoactivatable Materials for Versatile Single-Cell Patterning Based on the Photocaging of Cell-Anchoring Moieties through Lipid Self-Assembly.
J. Am. Chem. Soc. 144, 13154-13162 (2022)
PMID: 35767880 - Ohoka N, Suzuki M, Uchida T, Tsukumo Y, Yoshida M, Inoue T, Ohki H, *Naito M.
Development of a potent small-molecule degrader against oncogenic BRAF(V600E) protein that evades paradoxical MAPK activation.
Cancer Sci. 113, 2828-2838 (2022)
PMID: 35579105 - Zhang Q, Terawaki S, Oikawa D, Okina Y, Usuki Y, Ito H, *Tokunaga F.
Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43.
Cells. 11, 2398 (2022)
PMID: 35954242 - Oikawa D Gi M, Kosako H, Shimizu K, Takahashi H, Shiota M, Hosomi S, Komakura K, Wanibuchi H, Tsuruta D, Sawasaki T, *Tokunaga F.
OTUD1 deubiquitinase regulates NF-kB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways.
Cell Death & Disease. 13, 694 (2022)
PMID: 35941131 - Shimada T, Yabuki Y, Noguchi T, Tsuchida M, Komatsu R, Hamano S, Yamada M, Ezaki Y, Hirata Y, *Matsuzawa A.
The distinct roles of LKB1 and AMPK in p53-dependent apoptosis induced by cisplatin.
Int. J. Mol. Sci. 23, 10064 (2022)
PMID: 36077459 - Bürger M, Honda K, Kondoh Y, Hong S, Watanabe N, Osada H, Chory J.
Crystal structure of Arabidopsis DWARF14-LIKE2 (DLK2) reveals a distinct substrate binding pocket architecture.
Plant Direct.6, e446 (2022)
PMID: 36172078 - Davie T, Serrat X, Snider J, Štagljar I, Hirano H, Watanabe N, Osada H, Fraser AG.
Identification of a novel family of benzimidazole species-selective Complex I inhibitors as potential anthelmintics.
bioRxiv (2022) (not peer-reviewed) - Okano S, Kawaguchi Y, Kawano K, Hirose H, Imanishi M, Futaki S.
Split luciferase-based estimation of cytosolic cargo concentration delivered intracellularly via attenuated cationic amphiphilic lytic peptides.
Bioorg .Med. Chem. Lett. 72, 128875 (2022)
PMID: 35798239 - Li S, Ikeuchi K, Kato M, Buschauer R, Sugiyama T, Adachi S, Kusano H, Natsume T, Berninghausen O, Matsuo Y, Becker T, *Beckmann R, *Inada T.
Sensing of individual stalled 80S ribosomes by Fap1 for non-functional rRNA turnover.
Mol Cell. 82, 3424-3437 (2022)
PMID: 36113412
プレスリリース - *Nakazawa S, Mamiya R, Kawabata-Iwakawa R, Oikawa D, Kaira K, Tokunaga F, Nobusawa S, Sato Y, Sasaki A, Yajima T, Shirabe K.
Identification and molecular analysis of HOIP Q622H germline polymorphism.
Oncol Lett. 24, 394 (2022)
PMID: 36276481 - #Murakami Y, #Osawa H, #Kurohara T, Yanase Y, Ito T, Yokoo H, Shibata N, Naito M, Aritake K, *Demizu Y.
Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase.
RSC Med. Chem. 13, 1495-1503 (2022)
PMID: 36561070 - Liu R, Suzuki K, Ueda M, Takaoka Y.*
Coordinately regulated transcription factors EIN3/EIL1 and MYCs in ethylene and jasmonate signaling interact with the same domain of MED25.
Biosci. Biotechnol. Biochem. 86, 1405-1412 (2022)
PMID: 35876657 - Nakatsu K, *Okamoto A, *Hayashi G, *Murakami H.
Repetitive Thiazolidine Deprotection Using a Thioester-Compatible Aldehyde Scavenger for One-Pot Multiple Peptide Ligation.
Angew. Chem. Int. Ed. 61, e202206240 (2022)
PMID: 35881031 - *Yoshizato K, Taira T, Sato-Matsubara M, Sekiguchi S, Yabunaka Y, Kira Y, Ohashi T, Daikoku A, Ofusa K, Kadono C, Oikawa D, Matsubara T, Nakagama Y, Kido Y, Tokunaga F, Ikeda K, Kaneko A, Kawada N.
Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry.
J Biochem. 172, 205-216 (2022)
PMID: 35792074 - Lai WY, Wong Z, Chang CH, Samian MR, Watanabe N, Teh AH, Noordin R, Ong EBB.
Identifying Leptospira interrogans putative virulence factors with a yeast protein expression screen.
Appl. Microbiol. Biotech. 106, 6567-6581 (2022)
PMID: 36112204 - Lee J Y, Kim J M, Noguchi T, Matsuzawa A, Naganuma A, *Hwang G W.
Deubiquitinase USP54 attenuates methylmercury toxicity in human embryonic kidney 293 cells. Fudam. Toxicol. Sci. 9, 159-162 (2022) - #Yokoo H, #Misawa T, Kato T, Tanaka M, *Demizu Y, *Oba M.
Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine.
Bioorg. Med. Chem. 72, 116997 (2022)
PMID: 36088811 - Nakane K, Nagasawa H, Fujimura C, Koyanagi E, Tomoshige S, Ishikawa M, Sato S.
Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling.
Int. J. Mol. Sci. 23, 11622 (2022)
PMID: 36232972 - Kosaka T, *Yamaguchi S, Izuta S, Yamahira S, Shibasaki Y, Tateno H, *Okamoto A.
Bioorthogonal Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications.
J. Am. Chem. Soc. 144, 17980-17988 (2022)
PMID: 36126284 - Hirose H, Hirai Y, Sasaki M, Sawa H, Futaki S.
Quantitative Analysis of Extracellular Vesicle Uptake and Fusion with Recipient Cells.
Bioconjug. Chem. 33, 1852-1859 (2022)
PMID: 36194183 - Narita M, Denk T, Matsuo Y, Sugiyama T, Kikuguchi C, Ito S, Sato N, Suzuki T, Hashimoto S, Machova I, Tesina P, *Beckmann R, *Inada T.
A distinct human disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
Nat Commun. 13, 6411 (2022)
PMID: 36302773
プレスリリース - Akizuki Y, Morita M, Mori Y, Kaiho-Soma A, Dixit S, Endo A, Shimogawa M, Hayashi G, Naito M, Okamoto A, Tanaka K, Saeki Y, *Ohtake F.
cIAP1-based degraders induce degradation via branched ubiquitin architectures.
Nat Chem Biol. 19, 311-322 (2022)
PMID: 36316570 - Manzoor M, Muroi M, Ogawa N, Kobayashi H, Nishimura H, Chen D, Fasina OB, Wang J, Osada H, Yoshida M, Xiang L, Qi J.
Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo.
Food Funct. 13, 10923-10936 (2022)
PMID: 36205648 - Tsuchiya K, Kiyoshi M, Hashii N, Fujita M, Kurohara T, Ishii-Watabe A, Fukuhara K, *Misawa T, *Demizu Y.
Development of a penetratin-conjugated stapled peptide that inhibits Wnt/β-catenin signaling.
Bioorg. Med. Chem. 73, 117021 (2022)
PMID: 36198218 - Ohoka N, Suzuki M, Uchida T, Tsuji G, Tsukumo Y, Yoshida M, Inoue T, Demizu Y, Ohki H, *Naito M.
Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein.
ACS Med. Chem. Lett. 13, 1885-1891 (2022)
PMID: 36518702 - *Yamaguchi S, Ikeda R, Umeda Y, Kosaka T, Yamahira S, *Okamoto A.
Chemoenzymatic Labeling to Visualize Intercellular Contacts Using Lipidated Sortase A.
ChemBioChem 23, e202200474 (2022)
PMID: 35976800 - Ishigaki H, Yasui F, Nakayama M, Endo A, Yamamoto N, Yamaji K, Nguyen C, Kitagawa Y, Sanada T, Honda T, Munakata T, Higa M, Toyama S, Kono R, Takagi A, Matsumoto Y, Koseki A, Hayashi K, Shiohara M, Ishii K, Saeki Y, *Itoh Y, *Kohara M.
An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants.
Front. Microbiol. 13, 967019 (2022)
PMID: 36466631 - *Yamaguchi S, Yamamoto K, Yamamoto R, Takamori S, Ishiwatari A, Minamihata K, Nagamune T, *Okamoto A.
Intracellular Protein Photoactivation Using Sterically Bulky Caging.
ChemBioChem 23, e202200476 (2022)
PMID: 36173993 - Kikuchi A, Onoda H, Yamaguchi K, Kori S, Matsuzawa S, Chiba Y, Tanimoto S, Yoshimi S, Sato H, Yamagata A, Shirouzu M, Adachi N, Sharif J, Koseki H, Nishiyama A, Nakanishi M, Defossez PA , Arita K.
Structural basis for activation of DNMT1.
Nature Communications 13, 7130 (2022)
PMID: 36414620 - Hata K, Kobayashi N, Sugimura K, Qin W, Haxholli D, Chiba Y, Yoshimi S, Hayashi G, Onoda H, Ikegami T, Mulholland CB, Nishiyama A, Nakanishi M, Leonhardt H, Konuma T, Arita K.
Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger.
Nucleic Acids Res. 50, 12527-12542 (2022)
PMID: 36420895 - Chen B, Mao T, Qin X, Zhang W, Watanabe N, Li J.
Role of estrogen receptor signaling pathway-related genes in diffuse large B-cell lymphoma and identification of key targets via integrated bioinformatics analysis and experimental validation.
Front. Oncol. 12, 1029998 (2022)
PMID: 36531013 - Aoyama M, Ishikawa K, Nemoto S, Hirano H, Watanabe N, Osada H, Watanabe S, Semba K.
Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells.
J. Biol. Chem. 298, 102635 (2022)
PMID: 36273581 - Inagaki H, Hayashi K, Takaoka Y, Ito H, Fukumoto Y, Yajima-Nakagawa Y, Chen X, Shimosato-Nonaka M, Hassett E, Hatakeyama K, Hirakuri Y, Ishitsuka M, Yumoto E, Sakazawa T, Asahina M, Uchida K, Okada K, Yamane H, Ueda M, Miyamoto K.*
Genome Editing Reveals both the Cruicial Role of OsCOI2 in Jasmonate Signaling, and the Functional Diversity of COI1 Homologs in Rice Functional Diversity of COI1 Homologs in Rice.
Plant Cell Physiol. AOP (2022)
PMID: 36472361 - Saito R, Tada Y, Oikawa D, Sato Y, Seto M, Satoh A, Kume K, Ueki N, Nakashima M, Hayashi S, Toyoshima Y, Tokunaga F, Kawakami H, *Kakita A.
Spinocerebellar ataxia type 17-digenic TBP/STUB1 disease: neuropathologic features of an autopsied patient.
Acta Neuropathol Commun. 10, 177 (2022)
PMID: 36476347 - Takyo M, Sato Y, Hirata N, Tsuchiya K, Ishida H, Kurohara T, Yanase Y, Ito T, Ito N, Kanda Y, Yamamoto K, *Misawa T, *Demizu Y.
Oligoarginine-conjugated peptide foldamers inhibiting vitamin D receptor-mediated transcription.
ACS Omega. 7, 46573-46582 (2022)
PMID: 36570290 - Luo Y R, *Kudo T A, Tominami K, Izumi S, Tanaka T, Hayashi Y, Noguchi T, Matsuzawa A, Nakai J, Hong G, Wang H.
SP600125 enhances temperature-controlled repeated thermal stimulation-ynduced neurite outgrowth in PC12-P1F1 cells.
Int. J. Mol. Sci. 23, 15602 (2022)
PMID: 36555248 - Chen B, Zhou J, Mao T, Cao T, Hu S, Zhang W, Li X, Qin X, Liu X, Watanabe N, Li J.
The Critical Biomarkers Identifcation of Insulin Signaling Involved in Initiating cAMP Signaling Mediated Salivary Secretion in Sjogren Syndrome: Transcriptome Sequencing in NOD Mice Model.
Biol. Proc. Online 24, 26 (2022)
PMID: 36575389
総説論文・書籍 / Review Articles
- *Ohtake F.
Branched ubiquitin code: from basic biology to targeted protein degradation.
J Biochem. 171, 361-366 (2022)
PMID: 35037035 - *Matsumoto K, *Yoshida M.
Mammalian chemical genomics towards identifying targets and elucidating modes-of-action of bioactive compounds.
Chembiochem 23, e202100561 (2022)
PMID: 34813140 - Neal S, Ohtake F, Cuervo AM, Hegde RS, Jakob U, Lazarou M, Gilbert WV, Chen ZJ, Tooze SA, Haber JE, Walters KJ, Hartl FU.
Quality Control: Maintaining molecular order and preventing cellular chaos.
Mol Cell. 82, 1390-1397 (2022)
PMID: 35452608 - Tokunaga F*, Ikeda F*.
Linear ubiquitination in immune and neurodegenerative diseases, and beyond.
Biochem Soc Trans 50, 799-811 (2022)
PMID: 35343567 - Watanabe A, Yashiroda H, Ishihara S, Lo M, *Murata S.
The molecular mechanisms governing the assembly of the immuno- and thymoproteasomes in the presence of constitutive proteasomes.
Cells 11, 1580 (2022)
PMID: 35563886 - Tsuchiya K, Kurohara T, Fukuhara K, *Misawa T, *Demizu Y.
Helical Foldamers and stapled peptides as new modalities in drug discovery: Modulators of protein-protein interactions.
Processes10,924 (2022) - Hiroshi Ageta, Kunihiro Tsuchida.
Novel Therapeutic Strategies for Exosome-Related Diseases.
J Cell Signal. 3, 105-109 (2022) - *Sato Y.
Structural basis for the linkage specificity of ubiquitin-binding domain and deubiquitinase.
J Biochem. 172, 1-7 (2022)
PMID: 35394523 - *Naito M.
Targeted protein degradation and drug discovery.
J Biochem. 172, 61-69 (2022)
PMID: 35468190 - Yamamoto J, Ito T, Yamaguchi Y, *Handa H.
Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.
Chem Soc Rev. 51, 6234-6250 (2022)
PMID: 35796627 - Inoue A, Watanabe M, Kondo T, Hirano, S, *Hatakeyama S.
TRIM22 negatively regulates MHC-II expression.
Biochim. Biophys. Acta-Mol. Cell Res. 1869, 119318 (2022)
PMID: 35777501 - Oki N, Yamada S, Tanaka T, Fukui H, Hatakeyama S, *Okumura F.
Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylation.
Biochem. Biophys. Res. Commun. 625, 94-101 (2022)
PMID: 35952613 - *Yokoo H, Naganuma M, Oba M, *Demizu Y.
Recent advances in PROTAC technology toward new therapeutic modalities.
Chem. Biodivers. 19, e202200828 (2022)
PMID: 36124821 - Oba M, Demizu Y.
Cell-Penetrating Peptides: Design, Development and Applications, ISBN: 9783527350117, WILEY-VCH.
日本語総説/ Review in Japanese
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*佐藤裕介：「ユビキチンコードの構造生物学」生化学 第94巻第1号67-77 (2022)
- *内藤幹彦：「タンパク質分解技術と創薬〜PROTAC/SNIPER化合物の開発〜」 生化学 第94巻2号258-270（2022）
- *高岡洋輔, 上田実：「ジャスモン酸関連転写因子活性の化学制御の試み」 植物科学最前線 第13巻71-78（2022）
- *高岡洋輔, 上田実：「ジャスモン酸関連転写因子活性の化学制御の試み」 BSJ-Review『日本植物学会第85回大会シンポジウム特集号』Vol. 13B, 71-78（2022）
- 安田さや香、遠藤彬則、*佐伯 泰：「細胞内液滴の形態観察とFRAPによる動態観察」実験医学別冊『フロントランナー直伝 相分離解析プロトコール』126－134 (2022)
- *伊藤 拓水：「セレブロンモジュレーターとその標的分子」臨床血液 63 巻 6 号 p. 573-579 (2022)
- *内藤幹彦：「標的タンパク質分解誘導薬の開発展望」腫瘍内科 第29巻5号 626-631（2022）
- *内藤幹彦：「IAPの医薬品開発−IAPアンタゴニストとSNIPER」医学のあゆみ 第283巻5号 524-530（2022）
- 松尾芳隆, 稲田利文：「異常翻訳に惹起される品質管理と細胞応答」月刊 細胞 『翻訳制御の最前線』第54巻11号4-7 (2022)
- ＊内藤幹彦：「次世代医薬とバイオ医療」（長野哲雄・川西徹 編）東京化学同人 『第９章 新しい創薬手法―標的タンパク質を分解するPROTAC』227-231 (2022)
原著論文 / Publication
- Jimbo K, Hattori A, Koide S, Ito T, Sasaki K, Iwai K, Nannya Y, Iwama A, Tojo A, and Konuma T.
Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia.
Leukemia 37, 122-133 (2023)
PMID: 36352193 - Zhu W, Takeuchi S, Imai S, Terada T, Ueda T, Nasu Y, *Terai T, *Campbell R E.
Chemigenetic indicators based on synthetic chelators and green fluorescent protein.
Nat. Chem. Biol. 19, 38-44 (2023)
PMID: 36138142
プレスリリース - Hiragi K, Nishide A, Takagi K, Iwai K, Kim M, and Mizushima T.
Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.5.
J. Biochem. (2023) Jan 4:mvac109.
PMID: 36610722 - *Matsuo Y, Uchihashi T, *Inada T.
Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex.
Nat Commun. 14, 79 (2023)
PMID: 36627279
プレスリリース - Tomomatsu S, Watanabe A, Tesina P, Hashimoto S, Ikeuchi K, Li S, Matsuo Y, Beckmann R, *Inada T.
Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate No-go decay.
Nucleic Acids Res. 51, 253-270 (2023)
PMID: 36583309
プレスリリース - *Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, *Okamoto A.Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly.
J. Am. Chem. Soc. 145, 135-142 (2023)
PMID: 36538570 - Liu S, Morihiro K, Takeuchi F, Li Y, *Okamoto A.
Interstrand Crosslinking Oligonucleotides Elucidate the Effect of Metal Ions on the Methylation Status of Repetitive DNA Elements.
Front. Chem. 11, 1122474 (2023)
PMID: 36711237 - Miyashita R, *Nishiyama A, Qin W, Chiba Y, Kori S, Kato N, Konishi C, Kumamoto S, Kozuka-Hata H, Oyama M, Kawasoe Y, Tsurimoto T, Takahashi TS, Leonhardt H, Arita K, *Nakanishi M.
The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5.
eLife. AOP (2023)
PMID: 36734974 - Sanada S, *Maekawa M (co-first), Tate S, Nakaoka H, Fujisawa Y, Sayama K, *Higashiyama S.
SPOP is essential for DNA replication licensing through maintaining translation of CDT1 and CDC6 in HaCaT cells.
Biochem. Biophys. Res. Commun. 651, 30-38 (2023)
PMID: 36791496 - Sekiguchi Y, Takano S, Noguchi T, Kagi T, Komatsu R, Tan M, Hirata Y, *Matsuzawa A.
The NLRP3 inflammasome works as a sensor for detecting hypoactivity of the mitochondrial Src family kinases.
J. Immunol. (2023)
PMID: 36744909
プレスリリース - Kitagawa K, Okuma N, Yoshinaga M, Takemae H, Sato F, Sato S, Nakabayashi S, Yoshikawa H Y, Suganuma M, Luedtke N W, Matsuzaki T, *Tera M.
Ion-pair-enhanced double-click driven cell adhesion and altered expression of related genes.
Bioconjug. Chem. AOP (2023)
PMID: 36763006 - *Tesina P, Ebine S, Buschauer R, Thoms M, Matsuo Y, *Inada T, *Beckmann R.
Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol Cell. 83, 607-621 (2023)
PMID: 36804914 - Best K, Ikeuchi K, Kater L, Best D, Musial J, Matsuo Y, Berninghausen O, Becker T, *Inada T, *Beckmann R.
Structural basis for clearing of ribosome collisions by the RQT complex.
Nat Commun. 14, 921 (2023)
PMID: 36801861
総説論文・書籍 / Review Articles
- Sasaki K , Iwai K.
Role of linear ubiquitination in inflammatory responses and tissue homeostasis.
Int. Immunol. 35, 19-25 (2023)
PMID: 36149813 - Sato Y, Terawaki S, Oikawa D, Shimizu K, Okina Y, Ito H, *Tokunaga F.
Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer’s disease and amyotrophic lateral sclerosis.
Front Mol Biosci. AOP (2023) PMID: 36726375 - Hayashida R, Kikuchi R, Imai K, Kojima W, Yamada T, Iijima M, Sesaki H, Tanaka K, *Matsuda N, *Yamano K.
Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.
J Biol Chem. 299, 102822 (2023)
PMID: 36563856 - Oikawa D, Shimizu K, *Tokunaga F.
Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1.
Antioxidants. 12, 350 (2023)
PMID: 36829909 - Cho N, *Naito M.
Synthesis of SNIPERs against BCR-ABL with kinase inhibitors and a method to evaluate their growth inhibitory activity derived from BCR-ABL degradation.
Methods Enzymol. 681, 41-60 (2023)
PMID: 36764763 - Sato W, *Naito M.
Inducing Protein Degradation to Overcome Resistance to Kinase Inhibitors.
Biochemistry. 62, 557-558 (2023)
PMID: 35709688 - *Matsuo Y, *Inada T.
Co-translational quality control induced by translational arrest.
Biomolecules13, 317 (2023)
PMID: 36830686