New aspect of the ubiquitin system: its enormous roles in protein regulation

Proposed Research Projects

2015-2016

A01 Cellular, Physiological, and Pathological Roles of the Ubiquitin Conjugation System

Studies on ubiquitin modification and functional control of plant membrane proteins

Principal investigator: Junji Yamaguchi
(Professor, Faculty of Science, Hokkaido University)

Elucidation of novel regulatory mechanisms of phospho-signaling and stress response through ubiquitination

Principal investigator: Atsushi Matsuzawa
(Professor, Graduate School of Pharmaceutical Sciences, Tohoku University)

Roles of protein posttranslational modifications in the selectivity of ubiquitination

Principal investigator: Hirokazu Arimoto
(Professor, Graduate School of Life Sciences, Tohoku University)

Maintenance of genomic integrity regulated by ubiquitination of multinuclease complexes

Principal investigator: Takamune T. Saito
(Research Fellow, Institute of Advanced Technology, Kinki University)

Functional analyses on novel LUBAC-regulating E3s

Principal investigator: Fuminori Tokunaga
(Professor, Institute for Molecular and Cellular Regulation, Gunma University)

Regulation of clock proteins stabilities important for circadian rhythm generation

Principal investigator: Yoshitaka Fukada
(Professor, Graduate School of Science, The University of Tokyo)

Modulation of the host ubiquitin system by bacterial effector protein

Principal investigator: Minsoo Kim
(Associate Professor, The Hakubi center for Advanced Research, Kyoto University)

Structural basis for specific recognition of Lys63-linked polyubiquitin chains by RNF168

Principal investigator: Yusuke Sato
(Assistant professor, Synchrotron Radiation Research Organization, The University of Tokyo)

Functional crosstalk between K63 and linear polyubiquitin chains in oncogenic signals

Principal investigator: Jun-ichiro Inoue
(Professor, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo)

Functional analysis on a eukaryotic ubiquitin system identified in a prokaryote

Principal investigator: Tamotsu Kanai
(Lecturer, Graduate School of Engineering, Kyoto University)

Elucidation of a novel mechanism underlying the elimination of ubiquitinated proteins in the presence of proteasome inhibitors

Principal investigator: Akira Kakizuka
(Professor, Graduate School of Biostudies, Kyoto University)

Fine-tuning of ubiquitination-mediated DNA damage response

Principal investigator: Shinichiro Nakada
(Associate Professor, Graduate School of Medicine, Osaka University)

Regulation of iron nutrition by plant iron-binding ubiquitin ligases

Principal investigator: Takanori Kobayashi
(Associate Professor, Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University)

Regulatory roles of ubiquitin in maintenance DNA methylation

Principal investigator: Atsuya Nishiyama
(Associate Professor, Medical Department and Graduate School of Medical Science, Nagoya City University)

Regulation of mitochondrial dynamics by mitochondrial ubiquitin ligase MITOL

Principal investigator: Shigeru Yanagi
(Professor, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences)

Role of an endosomal E3 ligase in protein quality control

Principal investigator: Tsukasa Okiyoneda
(Associate Professor, Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University)

Imaging of the inhibitory signalosomes by ubiquitin for T cell activation regulation

Principal investigator: Tadashi Yokosuka
(Professor, Department of Immunology, Tokyo Medical University)

Post-translational modification of post-translational modifier: Analysis of intracellular function of phosphorylated ubiquitin

Principal investigator: Noriyuki Matsuda
(Project Leader, Ubiquitin Project, Tokyo Metropolitan Institute of Medical Science)

A02 Detection and Identification of Diverse Ubiquitin Conjugations in the Cell

Direct visualization of protein ubiquitination process

Principal investigator: Hiroki Konno
(Associate Professor, Bio-AFM Frontier Research Center, Kanazawa University)

Structural basis of the synthesis of linear ubiquitin chains

Principal investigator: Hidehito Tochio
(Professor, Department of Biophysics, Graduate School of Science, Kyoto University)

Development of an innovative technology for comprehensive identification of substrates for ubiquitin ligases

Principal investigator: Kanae Yumimoto
(Postdoctoral Fellow, Medical Institute of Bioregulation, Kyushu University)

Signal network systems modified by ubiquitylation in B cell differentiation

Principal investigator: Hisaaki Shinohara
(Senior research scientist, Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences)

2013-2014

A01 Cellular, Physiological, and Pathological Roles of the Ubiquitin Conjugation System

Studies on control of membrane traffic and chloroplast development mediated by ubiquitin modification

Principal investigator: Junji Yamaguchi
(Professor, Research Faculty of Science, Hokkaido University)

Elucidation of regulatory mechanism of Keap1 as ubiquitin ligase and oxidative stress sensor

Principal investigator: Takafumi Suzuki
(Assistant Professor, Tohoku University Graduate School of Medicine)

Novel roles of ubiquitination in quality control systems for aberrant mRNAs

Principal investigator: Toshifumi Inada
(Professor, Graduate School of Pharmaceutical Sciences, Tohoku University)

Regulation of stabilities of clock proteins by E3 ligases

Principal investigator: Yoshitaka Fukada
(Professor, Graduate School of Science, The University of Tokyo)

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by FAAP20

Principal investigator: Yusuke Sato
(Assistant Professor, Synchrotron Radiation Research Organization, The University of Tokyo)

Modulation of the host ubiquitination system by bacterial proteins

Principal investigator: Minsoo Kim
(Project Associate Professor, The Institute of Medical Science, The University of Tokyo)

Ubiquitin system involved in tissue fibrosis

Principal investigator: Masatoshi Kitagawa
(Professor, Hamamatsu University School of Medicine)

Hes1 protein stabilization and the stem cell regulation by the ubiquitin system

Principal investigator: Taeko Kobayashi
(Assistant Professor, Institute for Virus Research, Kyoto University)

Biochemical analysis on a eukaryotic ubiquitin system identified in a prokaryote

Principal investigator: Tamotsu Kanai
(Associate Professor, Graduate School of Engineering, Kyoto University)

Roles of a protein with multiple functional domains in selective ubiquitin signals and pathogenesis of disease

Principal investigator: Kenshi Komatsu
(Professor, Radiation Biology Center, Kyoto University)

Proteolytic control of iron metabolism by ubiquitylation

Principal investigator: Masaaki Nishiyama
(Assistant Professor, Medical Institute of Bioregulation, Kyushu University)

Regulation of peroxisomal protein import by Cys-ubiquitination of PTS1 receptor Pex5p

Principal investigator: Yukio Fujiki
(Professor, Faculty of Sciences, Kyushu University)

The roles of ubiquitin in cellular wound-healing

Principal investigator: Keiko Kono
(Associate Professor, Medical Department and Graduate School of Medical Science, Nagoya City University)

Molecular mechanism of how the E3 activity of Parkin is re-established by mitochondrial damage

Principal investigator: Noriyuki Matsuda
(Project Leader, Department of Advanced Science for Biomolecules, Tokyo Metropolitan Institute of Medical Science)

A02 Detection and Identification of Diverse Ubiquitin Conjugations in the Cell

Dynamics of post-translational protein modification by ubiquitin

Principal investigator: Hiroki Konno
(Associate Professor, Bio-AFM Frontier Research Center, Kanazawa University)

Structural basis of the synthesis of linear ubiquitin chains in cells

Principal investigator: Hidehito Tochio
(Associate Professor, Graduate School of Engineering, Kyoto University)

Manipulation of ubiquitylation with chemical compounds in cells

Principal investigator: Mikihiko Naito
(Director, Division of Biochemistry and Molecular Biology, National Institute of Health Sciences)