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研究成果

Research Results

本領域に参加している研究者の研究成果を掲載します。

2017.03.25

徳永 文稔(群馬大学・生体調節研究所 教授)

Hattori, M., Shimizu, A., Oikawa, D., Kamei, K., Kaira, K., Ishida-Yamamoto, A., Nakano, H., Sawamura, D., Tokunaga, F., and Ishikawa, O. (2017) ER stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa. Br. J. Dermatol., doi: 10.1016/j.bbrc.2017.02.040

2017.03.25

徳永 文稔(群馬大学・生体調節研究所 教授)

Goto, E. and Tokunaga, F. (2017) Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP. Biochem. Biophys. Res. Commun., doi: 10.1016/j.bbrc.2017.02.040

2017.03.25

徳永 文稔(群馬大学・生体調節研究所 教授)

Yamamotoya, T., Nakatsu, Y., Matsunaga, Y., Fukushima, T., Yamazaki, H., Kaneko, S., Fujishiro, M., Kikuchi, T., Kushiyama, A., Tokunaga, F., Asano, T., and Sakoda, H. (2017) Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice. Int. J. Mol. Sci., doi: 10.3390/ijms18020326

2017.03.25

徳永 文稔(群馬大学・生体調節研究所 教授)

Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K., and Inoue, J.I. (2017) HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. PLoS Pathog., doi: 10.1371/journal.ppat.1006162

2017.03.25

徳永 文稔(群馬大学・生体調節研究所 教授)

Omura, H., Oikawa, D., Nakane, T., Kato, M., Ishii, R., Ishitani, R., Tokunaga, F., and Nureki, O. (2016) Structural and functional analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. Sci. Rep., doi: 10.1038/srep34756

2017.03.25

徳永 文稔(群馬大学・生体調節研究所 教授)

Nakazawa, S., Oikawa, D., Ishii, R., Ayaki, T., Takahashi, H., Takeda, H., Ishitani, R., Kamei, K., Takeyoshi, I., Kawakami, H., Iwai, K., Hatada, I., Sawasaki, T., Ito, H., Nureki, O., and Tokunaga, F. (2016) Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat. Commun., doi: 10.1038/ncomms12547

2017.03.25

徳永 文稔(群馬大学・生体調節研究所 教授)

Saitoh, Y., Hamano, A., Mochida, K., Kakeya, A., Uno, M., Tsuruyama, E., Ichikawa, H., Tokunaga, F., Utsunomiya, A., Watanabe, T., and Yamaoka, S. (2016) A20 targets caspase-8 and FADD to protect HTLV-I infected cells. Leukemia, doi: 10.1038/leu.2015.267

2017.03.25

徳永 文稔(群馬大学・生体調節研究所 教授)

Kumanomidou, T., Nishio, K., Takagi, K., Nakagawa, T., Suzuki, A., Yamane, T., Tokunaga, F., Iwai, K., Murakami, A., Yoshida, Y., Tanaka, K., and Mizushima, T. (2015) The structural differences between a glycoprotein specific F-box protein Fbs1 and its homologous protein FBG3. PLoS One, doi: 10.1371/journal.pone.0140366

2017.03.25

徳永 文稔(群馬大学・生体調節研究所 教授)

Sato, Y., Goto, E., Shibata, Y., Kubota, Y., Yamagata, A., Goto-Ito, S., Kubota, K., Inoue, J.I., Takekawa, M., Tokunaga, F., and Fukai, S. (2015) Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity. Nat. Struct. Mol. Biol., doi: 10.1038/nsmb.2970

2017.03.25

水島 恒裕(兵庫県立大学・大学院生命理学研究科 教授)

Nishio, K., Yoshida, Y., Tanaka, K., and Mizushima, T. (2016) Structural analysis of a function-associated loop mutant of the substrate recognition domain of Fbs1 ubiquitin ligase. Acta Cryst F72, doi:10.1107/S2053230X16011018